Correlation of gut hormones with irritable bowel syndrome.

Abstract:

BACKGROUND:Irritable bowel syndrome (IBS) is a functional bowel disorder which is characterized by abdominal pain and disturbed bowel habits. The pathophysiological mechanism is complex and still remains incompletely clear. Alterations at both the central and the peripheral level are thought to contribute to the symptoms of IBS, including psychosocial factors, visceral hypersensitivity and abnormal gastrointestinal motility and secretion. Several gut peptides contribute to the regulation of gastrointestinal function, but little is known about gut hormone secretion in IBS. METHODS:We evaluated the concentrations of cholecystokinin (CCK), vasoactive intestinal peptide (VIP), somatostatin, substance P, neuropeptide Y (NPY) in plasma and in sigmoid tissue in 40 patients with IBS and 15 age- and gender-matched controls by using radioimmunoassay. RESULTS:IBS patients had higher plasma level of CCK (p < 0.01), and the level of CCK in the sigmoid was also increased compared with controls (p < 0.05). The levels of somatostatin and substance P in fasting plasma and in the sigmoid were not different between IBS patients and control subjects (p > 0.05), but the levels of VIP in sigmoid tissue or in plasma were higher in IBS patients than in control group (p < 0.01). The NPY levels in both plasma and the sigmoid were significantly lower in IBS patients than in controls (p < 0.05). Plasma NPY level in patients with IBS with diarrhea as a predominant bowel pattern was lower than in patients with IBS with constipation as a predominant bowel pattern. CONCLUSION:IBS patients have increased levels of CCK and VIP and decreased NPY levels in fasting plasma and sigmoid tissue. These alterations of VIP, CCK and NPY may play a role in the pathogenesis of IBS.

journal_name

Digestion

journal_title

Digestion

authors

Zhang H,Yan Y,Shi R,Lin Z,Wang M,Lin L

doi

10.1159/000165352

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

72-6

issue

2-3

eissn

0012-2823

issn

1421-9867

pii

000165352

journal_volume

78

pub_type

杂志文章
  • Endoscopic manometry in the diagnosis of the postcholecystectomy pain syndrome.

    abstract::A manometric study of the distal biliary tract was carried out by means of a side-hole perfused catheter passed through the papilla Vateri during duodenoscopy in patients with postcholecystectomy biliary pain not due to stones or inflammation of the biliary tree. The sphincter of Oddi showed in these cases a significa...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198979

    authors: Bortolotti M,Caletti GC,Brocchi E,Bersani G,Caletti T,Guizzardi G,Labò G

    更新日期:1983-01-01 00:00:00

  • Comparison of caerulein and cholecystokinin effects upon enzyme concentrations in duodenal aspirates.

    abstract::The effect of maximal doses of cholecystokinin and caerulein on lipase and chymotropsin concentrations were compared in large groups of patients with almost equal capacities of bicarbonate secretion. The responsiveness of the pancreas is, as a whole, higher with caerulein than with cholecystokinin, this feature being ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197987

    authors: Minaire Y,Descos L

    更新日期:1977-01-01 00:00:00

  • Somatostatin receptor imaging: predictive and prognostic considerations.

    abstract::Compared with other imaging modalities and clinical investigation, the 111In-pentetreotide scan identified additional metastatic disease sites in 12 carcinoid patients and 2 occult primaries, and influenced the therapeutic outcome in 36 patients [29 carcinoids, 2 atypical carcinoids, 3 cancers of unknown primaries (CU...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201396

    authors: Anthony LB,Martin W,Delbeke D,Sandler M

    更新日期:1996-01-01 00:00:00

  • Pharmacodynamic effects of Sandostatin in the gastrointestinal tract.

    abstract::Somatostatin is widely distributed throughout the human gastrointestinal system. There it is found in neurons and fibers of both the submucosal and the myenteric plexus and the pancreas as well as in the D cells of the stomach, gut and pancreatic islets. Whereas in the intestinal nervous system, in the duodenum and th...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201070

    authors: Gyr KE,Meier R

    更新日期:1993-01-01 00:00:00

  • Fasting and postprandial serum bile acid concentrations in normal persons using an improved GLC method.

    abstract::An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198094

    authors: Pennington CR,Ross PE,Bouchier IA

    更新日期:1978-01-01 00:00:00

  • OctreoTher: ongoing early clinical development of a somatostatin-receptor-targeted radionuclide antineoplastic therapy.

    abstract::OctreoTher ((90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide, a.k.a. (90)Y-SMT 487) consists of a somatostatin peptide analogue (Tyr(3)-octreotide), coupled with a complexing moiety (DOTA), and labeled with a tightly bound beta-emitter (yttrium-90). By targeting somatostatin receptor-positive tumors (as imaged by OctreaScan it m...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000051858

    authors: Smith MC,Liu J,Chen T,Schran H,Yeh CM,Jamar F,Valkema R,Bakker W,Kvols L,Krenning E,Pauwels S

    更新日期:2000-01-01 00:00:00

  • Can daily dietary arginine supplement affect the function and subpopulation of lymphocytes in patients with advanced gastric cancer?

    abstract::Since arginine can stimulate lymphocyte proliferation in the healthy human, its effect on lymphocyte proliferation in vitro was studied in 7 patients with far advanced gastric cancer. These patients with normal nourishment were ambulatory and could consume a regular diet. A daily dietary supplement of 30 g arginine fo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201023

    authors: Wu CW,Chi CW,Chiu CC,Wu HS,Liu WY,P'eng FK,Wang SR

    更新日期:1993-01-01 00:00:00

  • True adenomas of the cardia: a case series of 3 patients.

    abstract:BACKGROUND/AIM:True adenomas of the cardia appear to be extremely rare lesions. There are no data on the natural history and histopathological background of these lesions. We report 3 patients with true adenomas of the cardia. METHODS AND RESULTS:Three patients with polypoid masses at the cardia below the Z-line were ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000121413

    authors: Bajbouj M,von Weyhern C,Becker V,Seidl S,Ott R,Schatke W,Fend F,Schmid RM,Meining A

    更新日期:2008-01-01 00:00:00

  • Clinical isolation and characterization of Yersinia enterocolitica in China using real-time PCR and culture method.

    abstract:OBJECTIVE:To carry out a preliminary epidemiological investigation of Yersinia enterocolitica from a clinical perspective in China and to further validate the consistency of real-time polymerase chain reaction (RT-PCR) and culture method. METHODS:700 stool samples were randomly and continuously collected from in- and ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000108646

    authors: Zheng H,Wang J,Sun Y,Jiang B

    更新日期:2007-01-01 00:00:00

  • Gastrin and gastric enterochromaffin-like cell carcinoids in the rat.

    abstract::Life-long administration (greater than or equal to 2 years) of a number of long-acting gastric acid inhibitors (including H2-receptor antagonists, omeprazole and ciprofibrate) has been associated with the development of gastric enterochromaffin-like cell (ECL cell) carcinoids in rats. It has been postulated that they ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200510

    authors: Carlsson E,Havu N,Mattsson H,Ekman L

    更新日期:1990-01-01 00:00:00

  • A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan.

    abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000507570

    authors: Kudo T,Fujii T,Maisawa SI,Sasaki M,Uchida K,Ida S,Kagimoto S,Yoden A,Shimizu T

    更新日期:2020-05-18 00:00:00

  • Surgical management of carcinoid tumors: role of debulking and surgery for patients with advanced disease.

    abstract::Surgery is the only potentially curative treatment for patients with carcinoid tumors. Patients with localized disease even with lymph node metastases can be resected for potential cure. Patients with distant metastatic disease have been reported to be cured by resection of all tumor. However, long-term follow-up of t...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201209

    authors: Norton JA

    更新日期:1994-01-01 00:00:00

  • Vitamin A status in 137 patients with Crohn's disease.

    abstract::Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 pati...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199495

    authors: Imes S,Pinchbeck B,Dinwoodie A,Walker K,Thomson AB

    更新日期:1987-01-01 00:00:00

  • Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects.

    abstract:BACKGROUND:The importance of microbiota infiltrating the gut mucus layer has been reported in the pathogenesis of various gastrointestinal and systemic diseases. However, little is known about the mucosa-associated microbiota (MAM) in healthy subjects. The present study aimed to clarify the characteristics of the gastr...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000496102

    authors: Kashiwagi S,Naito Y,Inoue R,Takagi T,Nakano T,Inada Y,Fukui A,Katada K,Mizushima K,Kamada K,Uchiyama K,Handa O,Ishikawa T,Itoh Y

    更新日期:2020-01-01 00:00:00

  • Advances in the Treatment of Cholinergic Anti-Inflammatory Pathways in Gastrointestinal Diseases by Electrical Stimulation of Vagus Nerve.

    abstract:BACKGROUND:The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve (VN), modulates the immune system in the body. Recent studies of VN stimulation (VNS) in vivo systems have shown that it plays an anti-inflammatory role through CAIP. Inflammatory...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000504474

    authors: Lei W,Duan Z

    更新日期:2019-11-29 00:00:00

  • Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis.

    abstract::Leukocytapheresis has recently been used to induce remission in patients with ulcerative colitis (UC) who fail to respond to corticosteroids. We could not find a report in the literature on leukocytapheresis for UC with gestational exacerbation. We have recently encountered this unique condition and report the details...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000095478

    authors: Okada H,Makidono C,Takenaka R,Hiraoka S,Fujiwara A,Kato J,Kawahara Y,Kawamoto H,Mizuno M,Shiratori Y

    更新日期:2006-01-01 00:00:00

  • Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis.

    abstract::Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/o...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000111486

    authors: Nakamura T,Nagahori M,Kanai T,Watanabe M

    更新日期:2008-01-01 00:00:00

  • Faecal characteristics and colonic intraluminal pressure in diverticular disease.

    abstract::Daily faecal calcium and magnesium outputs were inversely related to food-stimulated colonic intraluminal pressure in diverticular disease subjects. There was no relationship to sodium potassium and bile acid concentrations, nor to intestinal transit. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198481

    authors: Eastwood MA,Smith AN,Mitchell WD,Pritchard JL

    更新日期:1980-01-01 00:00:00

  • Chest Pain after Endoscopic Submucosal Dissection for Esophageal Cancer: The Simple and Clinically Useful Surrogate Marker for Transmural Thermal Injury by Electrocoagulation.

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000510353

    authors: Sakai M,Sohda M,Saito H,Ubukata Y,Nakazawa N,Kuriyama K,Hara K,Sano A,Ogata K,Yokobori T,Kuwano H,Shirabe K,Saeki H

    更新日期:2020-10-08 00:00:00

  • Changes of rat gastric mucus glycoproteins in cytoprotection: influences of prostaglandin derivatives.

    abstract::The effects of two synthetic prostaglandin E derivatives on mucus glycoproteins in the stomachs of rats were evaluated. Neither derivative caused change in mucus glycoprotein content in the gastric corpus or antrum, but both increased the biosynthetic activity of mucus glycoproteins in these regions (about 15-30%). Fu...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199621

    authors: Ishihara K,Kuwata H,Ohara S,Okabe H,Hotta K

    更新日期:1988-01-01 00:00:00

  • Hydrokinetic activity of secretion and secretin analogues, modified in the N-terminal sequence, and of vasoactive intestinal peptide in the dog pancreas.

    abstract::In the dog pancreas in vivo, the biological activity of secretin and vasoactive intestinal peptide was compared to that of secretin analogues modified in their N-terminal hexapeptide and to X-secretion (alpha, beta-Asp3-secretin) and Y-secretin (a conversion product of X-secretin consisting of about 15% secretin and 8...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198600

    authors: Lehnert P,Forell MM,Jaeger E,Moroder L,Wünsch E

    更新日期:1981-01-01 00:00:00

  • Interferons alone or in combination with chemotherapy or other biologicals in the treatment of neuroendocrine gut and pancreatic tumors.

    abstract::The treatment of malignant neuroendocrine gut and pancreatic tumors provides a therapeutic challenge. Surgery as well as medical treatment rarely cure the patient at this stage. Symptoms related to secretory products from the tumor might be life-threatening or at least reduce the quality of life considerably. Interfer...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201204

    authors: Oberg K,Eriksson B,Janson ET

    更新日期:1994-01-01 00:00:00

  • Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients.

    abstract:BACKGROUND/AIMS:There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patien...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000326854

    authors: Kim JH,Kim SY,Jung ES,Jung SW,Koo JS,Kim JH,Yeon JE,Kwon SY,Lee SW,Byun KS,Lee CH

    更新日期:2011-01-01 00:00:00

  • Metabolic Alterations in Celiac Disease Occurring after Following a Gluten-Free Diet.

    abstract:BACKGROUND AND AIM:Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000495749

    authors: Ciccone A,Gabrieli D,Cardinale R,Di Ruscio M,Vernia F,Stefanelli G,Necozione S,Melideo D,Viscido A,Frieri G,Latella G

    更新日期:2019-01-01 00:00:00

  • Treatment of haemorrhoids by rubber band ligation.

    abstract::Outpatient treatment of haemorrhoids by elastic band ligation without anaesthetic was performed in 75 patients. Clinical review showed that 65 returned to work within 24 h of ligation, 8 in 48 h and 2 after 48 h. No patient required hospitalisation for either rectal bleeding or pain after ligation. In the first week a...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197658

    authors: Panda AP,Laughton JM,Elder JB,Gillespie IE

    更新日期:1975-01-01 00:00:00

  • Patency Capsule Tolerability in School-Aged Children.

    abstract:BACKGROUND:A patency capsule (PC) can help predict capsule endoscope (CE) retention; however, PC tolerability is unknown in children. We retrospectively evaluated PC tolerability in school-aged children. METHODS:Sixty-one patients (median age, 12.9 years; range 7.4-17.3 years) who underwent PC examination were analyze...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000477579

    authors: Tokuhara D,Watanabe K,Cho Y,Shintaku H

    更新日期:2017-01-01 00:00:00

  • Analysis of Wire-Guided Hemostasis Introducer for Percutaneous Therapy of Bile Duct Stones.

    abstract:BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000485179

    authors: Hollenbach M,Feisthammel J,Mössner J,Hoffmeister A

    更新日期:2018-01-01 00:00:00

  • Trends in pre-liver transplant screening for cholangiocarcinoma among patients with primary sclerosing cholangitis.

    abstract:BACKGROUND:Cholangiocarcinoma (CCA) is the most common hepatobiliary malignancy complicating primary sclerosing cholangitis (PSC). Unfortunately, timely diagnosis of CCA in PSC patients remains challenging. AIM:To investigate the strategies among liver centers regarding pre-transplant screening for CCA in patients wit...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000357445

    authors: Trilianos P,Selaru F,Li Z,Gurakar A

    更新日期:2014-01-01 00:00:00

  • Treatment of peptic ulcer.

    abstract::The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the infection is especially i...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000007522

    authors: Tytgat GN

    更新日期:1998-08-01 00:00:00

  • Study on pancreatic insufficiency (chronic pancreatitis) and steatorrhea in Japanese patients with low fat intake.

    abstract::The incidence of steatorrhea is said to be lower and its grade milder in Japanese because their fat intake is lower than that of Europeans and Americans. Failure to take this into account creates difficulties when attempting to compare data on pancreatic exocrine insufficiency in different countries. The authors exami...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051462

    authors: Nakamura T,Tando Y,Yamada N,Watanabe T,Ogawa Y,Kaji A,Imamura K,Kikuchi H,Suda T

    更新日期:1999-01-01 00:00:00