Correlation of gut hormones with irritable bowel syndrome.


BACKGROUND:Irritable bowel syndrome (IBS) is a functional bowel disorder which is characterized by abdominal pain and disturbed bowel habits. The pathophysiological mechanism is complex and still remains incompletely clear. Alterations at both the central and the peripheral level are thought to contribute to the symptoms of IBS, including psychosocial factors, visceral hypersensitivity and abnormal gastrointestinal motility and secretion. Several gut peptides contribute to the regulation of gastrointestinal function, but little is known about gut hormone secretion in IBS. METHODS:We evaluated the concentrations of cholecystokinin (CCK), vasoactive intestinal peptide (VIP), somatostatin, substance P, neuropeptide Y (NPY) in plasma and in sigmoid tissue in 40 patients with IBS and 15 age- and gender-matched controls by using radioimmunoassay. RESULTS:IBS patients had higher plasma level of CCK (p < 0.01), and the level of CCK in the sigmoid was also increased compared with controls (p < 0.05). The levels of somatostatin and substance P in fasting plasma and in the sigmoid were not different between IBS patients and control subjects (p > 0.05), but the levels of VIP in sigmoid tissue or in plasma were higher in IBS patients than in control group (p < 0.01). The NPY levels in both plasma and the sigmoid were significantly lower in IBS patients than in controls (p < 0.05). Plasma NPY level in patients with IBS with diarrhea as a predominant bowel pattern was lower than in patients with IBS with constipation as a predominant bowel pattern. CONCLUSION:IBS patients have increased levels of CCK and VIP and decreased NPY levels in fasting plasma and sigmoid tissue. These alterations of VIP, CCK and NPY may play a role in the pathogenesis of IBS.






Zhang H,Yan Y,Shi R,Lin Z,Wang M,Lin L




Has Abstract


2008-01-01 00:00:00














  • Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: a population-based study.

    abstract:BACKGROUND/AIMS:People may have symptoms of multiple disorders at the same time. We aimed to determine prevalence and risk factors for overlaps between gastroesophageal reflux disease (GERD), dyspepsia and irritable bowel syndrome (IBS) in a Korean population. METHODS:A cross-sectional survey was performed on 1,688 ra...


    pub_type: 杂志文章


    authors: Lee SY,Lee KJ,Kim SJ,Cho SW

    更新日期:2009-01-01 00:00:00

  • Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.

    abstract:BACKGROUND AND AIM:A recent basic study identified that Dicer is contained in exosomes derived from cancer cells and plays crucial roles in microRNA maturation and cancer development. Based on this novel basic concept, we analyzed the usefulness of serum exosomal Dicer as a diagnostic biomarker for gastrointestinal can...


    pub_type: 杂志文章


    authors: Okuda Y,Shimura T,Iwasaki H,Katano T,Kitagawa M,Nishigaki R,Fukusada S,Natsume M,Tanaka M,Nishie H,Ozeki K,Yamada T,Kataoka H

    更新日期:2020-10-13 00:00:00

  • Clinical, controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract.

    abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...


    pub_type: 临床试验,杂志文章


    authors: Coraggio F,Bertini G,Catalano A,Scarpato P,Gualdieri L

    更新日期:1989-01-01 00:00:00

  • Role of the ileocecal valve and site of intestinal resection in malabsorption after extensive small bowel resection.

    abstract::Intestinal absorption after extensive small bowel resections, for diseases other than Crohn's disease, was studied in 17 patients. When the ileocecal valve and the right colon were preserved, malabsorption was transient and moderate and had no prejudicial nutritional effect (fecal fat: 8.8 +/- 1.8 g/24 h in resections...


    pub_type: 杂志文章


    authors: Cosnes J,Gendre JP,Le Quintrec Y

    更新日期:1978-01-01 00:00:00

  • A novel diamino-pyridine derivative prevents excessive leukocyte infiltration in aggravation of acute necrotizing pancreatitis.

    abstract::Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...


    pub_type: 杂志文章


    authors: Yamauchi J,Sunamura M,Shibuya K,Takeda K,Kobari M,Matsuno S

    更新日期:1999-01-01 00:00:00

  • Quantitative histomorphometric study of the jejunal mucosa in chronic alcoholics.

    abstract::Jejunal suction biopsies of 18 chronic alcoholics (alcohol intake of more than 100 g of ethanol per day for several years) and 10 nonalcoholic control subjects were analyzed quantitatively using the microdissection technique described by Clarke. Both groups were comparable concerning age, body weight and sex. The dura...


    pub_type: 杂志文章


    authors: Bode JC,Knüppel H,Schwerk W,Lorenz-Meyer H,Dürr HK

    更新日期:1982-01-01 00:00:00

  • The role of catecholamines in the control of gastrin and acid secretion during insulin hypoglycaemia in man.

    abstract::5 adrenalectomized subjects and 8 healthy volunteers underwent an insulin test during which acid secretion and plasma adrenaline, noradrenaline, dopamine and gastrin concentrations were measured. Plasma glucose concentration fell by greater than 50% in all subjects. The mean plasma adrenaline concentration increased m...


    pub_type: 杂志文章


    authors: Järhult J,Hamberger B,Lanthén G,Ors M,Uvnäs-Wallensten K

    更新日期:1981-01-01 00:00:00

  • Effects of chronic nitric oxide synthase inhibition in cold-restraint and ethanol-induced gastric mucosal damage in rats.

    abstract::Gastric actions of Nw-nitro-1-arginine methyl ester (L-NAME) were investigated in rats, as this agent is a reliable nitric oxide synthase inhibitor L-NAME solutions were placed in subcutaneous osmotic minipumps which continuously released L-NAME at 0.1, 1.0, 10, or 40 mg/kg/day. L-NAME dose and time-dependently enhanc...


    pub_type: 杂志文章


    authors: Qiu BS,Pfeiffer CJ,Cho CH

    更新日期:1996-01-01 00:00:00

  • Protective action of omeprazole, a benzimidazole derivative, on gastric mucosal damage by aspirin and ethanol in rats.

    abstract::This study was designed to compare the influence of omeprazole, a potent inhibitor of H+/K+-ATP-ase involved in the final step of H+ secretion and prostaglandin (PG) I2 on the formation of gastric mucosal lesions induced by absolute ethanol or acidified aspirin (ASA). Omeprazole given intragastrically in both inhibito...


    pub_type: 杂志文章


    authors: Konturek SJ,Brzozowski T,Radecki T

    更新日期:1983-01-01 00:00:00

  • Evaluation of small bowel injury in patients with rheumatoid arthritis by capsule endoscopy: effects of anti-rheumatoid arthritis drugs.

    abstract:BACKGROUND AND AIM:The medical treatment of rheumatoid arthritis (RA) includes nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose corticosteroids, and disease-modifying antirheumatic drugs (DMARDs). We evaluated the incidence of small bowel injury in RA patients who were taking anti-RA drugs with or without concom...


    pub_type: 杂志文章


    authors: Sugimori S,Watanabe T,Tabuchi M,Kameda N,Machida H,Okazaki H,Tanigawa T,Yamagami H,Shiba M,Watanabe K,Tominaga K,Fujiwara Y,Oshitani N,Koike T,Higuchi K,Arakawa T

    更新日期:2008-01-01 00:00:00

  • Introducing genetic testing for adult-type hypolactasia.

    abstract:BACKGROUND AND AIMS:To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance. METHODS:In total, 166 consecutive patients with gastrointestinal symptoms mimicking hypolactasia admitted to the clin...


    pub_type: 杂志文章


    authors: Büning C,Genschel J,Jurga J,Fiedler T,Voderholzer W,Fiedler EM,Worm M,Weltrich R,Lochs H,Schmidt H,Ockenga J

    更新日期:2005-01-01 00:00:00

  • Radiation pancreatitis: a clinical entity?

    abstract::2 cases of pancreatic disease in patients with malabsorption following small bowel radiation injury are reported. It is suggested that the pancreatic disease present in these patients occurred as a result of previous radiotherapy. ...


    pub_type: 杂志文章


    authors: Mitchell CJ,Simpson FG,Davison AM,Losowsky MS

    更新日期:1979-01-01 00:00:00

  • Evaluation of faecal occult blood test and lactoferrin latex agglutination test in screening hospitalized patients for diagnosing inflammatory and non-inflammatory diarrhoea in Dhaka, Bangladesh.

    abstract:BACKGROUND:Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocyt...


    pub_type: 杂志文章


    authors: Ashraf H,Beltinger J,Alam NH,Bardhan PK,Faruque AS,Akter J,Salam MA,Gyr N

    更新日期:2007-01-01 00:00:00

  • Pentoxifylline accelerates gastric ulcer healing in rats: roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing.

    abstract:BACKGROUND/AIMS:Pentoxifylline has many anti-inflammatory properties including inhibition of production of tumor necrosis factor alpha (TNF-alpha). Although pentoxifylline prevents several types of gastric mucosal injury, the effect of this drug on ulcer healing is unknown. In this study, we examined the effect of pent...


    pub_type: 杂志文章


    authors: Shimizu N,Watanabe T,Arakawa T,Fujiwara Y,Higuchi K,Kuroki T

    更新日期:2000-01-01 00:00:00

  • The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...


    pub_type: 杂志文章,多中心研究


    authors: Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

    更新日期:2007-01-01 00:00:00

  • Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer.

    abstract:BACKGROUND/AIMS:Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHOD...


    pub_type: 杂志文章


    authors: Kitamura S,Muguruma N,Okamoto K,Tanahashi T,Fukuya A,Tanaka K,Fujimoto D,Kimura T,Miyamoto H,Bando Y,Takeuchi H,Shiba M,Takayama T

    更新日期:2017-11-01 00:00:00

  • Effect of wheat bran upon gastro-intestinal transit in germ-free and conventional rats.

    abstract::Germ-free and conventional rats were fed a semi-synthetic diet including 10% wheat bran for 1 month. They were compared to similar rats fed the same diet without bran. Transit of polyethylene glycol (PEG) 4000 was studied in giving the marker either in saline or in the diet. The presence of a bacterial flora was found...


    pub_type: 杂志文章


    authors: Riottot M,Sacquet E,Leprince C

    更新日期:1984-01-01 00:00:00

  • Comparison of bile salt perturbation of duodenal and jejunal isolated brush-border membranes.

    abstract::Rabbit duodenal and jejunal brush-border membrane vesicle integrity, fluidity and passive proton permeability were studied after in vitro exposure to deoxycholate, glycodeoxycholate or taurodeoxycholate. Duodenal and jejunal membrane mean vesicle volume [0.54 (0.05) and 0.54 (0.03) microliters/mg, mean values with SE ...


    pub_type: 杂志文章


    authors: Zhao DL,Hirst BH

    更新日期:1990-01-01 00:00:00

  • Effect of cell proliferation on healing of gastric and duodenal ulcers in rats.

    abstract::The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...


    pub_type: 杂志文章


    authors: Takeuchi K,Johnson LR

    更新日期:1986-01-01 00:00:00

  • Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis.

    abstract::Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/o...


    pub_type: 杂志文章,评审


    authors: Nakamura T,Nagahori M,Kanai T,Watanabe M

    更新日期:2008-01-01 00:00:00

  • Effect of fasting on diarrhoea in collagenous colitis.

    abstract:BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...


    pub_type: 杂志文章


    authors: Bohr J,Järnerot G,Tysk C,Jones I,Eriksson S

    更新日期:2002-01-01 00:00:00

  • Total denervation of the pancreas does not alter the pancreatic polypeptide response to food intake.

    abstract::The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...


    pub_type: 杂志文章


    authors: Köhler H,Becker HD

    更新日期:1987-01-01 00:00:00

  • Characterization of the gastroprotective effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine hydrochloride, a non-H1/non-H2 histamine antagonist.

    abstract::N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than o...


    pub_type: 杂志文章


    authors: Glavin GB,Gerrard JM

    更新日期:1990-01-01 00:00:00

  • Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.

    abstract:BACKGROUND/AIM:Studies have demonstrated an important role for endogenous PG and NO in the healing of chronic gastric ulcers. We investigated the effects of COX and NOS inhibitors on the healing of duodenal ulcers, in comparison with gastric ulcers, in rats. METHODS:Gastric and duodenal ulcers were induced by serosal ...


    pub_type: 杂志文章


    authors: Araki H,Komoike Y,Matsumoto M,Tanaka A,Takeuchi K

    更新日期:2002-01-01 00:00:00

  • Evaluation of the 75Se-l-selenomethionine test for pancreatic disease. Studies on gel filtration.

    abstract::Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...


    pub_type: 杂志文章


    authors: Pointner H,Kletter K

    更新日期:1980-01-01 00:00:00

  • Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction.

    abstract:INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...


    pub_type: 杂志文章


    authors: Li M,Oshima T,Ito C,Yamada M,Tomita T,Fukui H,Miwa H

    更新日期:2019-09-18 00:00:00

  • Fasting and postprandial serum bile acid concentrations in normal persons using an improved GLC method.

    abstract::An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeo...


    pub_type: 杂志文章


    authors: Pennington CR,Ross PE,Bouchier IA

    更新日期:1978-01-01 00:00:00

  • Effects of type-2 diabetes and troglitazone on the expression patterns of small intestinal sugar transporters and PPAR-gamma in the Zucker diabetic fatty rat.

    abstract:BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...


    pub_type: 杂志文章


    authors: Corpe C,Sreenan S,Burant C

    更新日期:2001-01-01 00:00:00

  • Defective inhibition of gastrin release by antral distension in duodenal ulcer patients.

    abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...


    pub_type: 杂志文章


    authors: Sjövall M,Lindstedt G,Olbe L,Lundell L

    更新日期:1992-01-01 00:00:00

  • Poor Prognosis of Advanced Cholangiocarcinoma: Real-World Data from a Tertiary Referral Center.

    abstract:BACKGROUND:Incidence of cholangiocarcinoma (CCA) in western countries is rising. In the palliative setting, chemotherapy is the only established treatment. The evidence for other treatments including locoregional therapy is low. However, such individual treatments are offered in a real-world setting. The aim of this st...


    pub_type: 杂志文章


    authors: Koch C,Franzke C,Bechstein WO,Schnitzbauer AA,Filmann N,Vogl T,Gruber-Rouh T,Zeuzem S,Waidmann O,Trojan J

    更新日期:2020-01-01 00:00:00