Treatment of peptic ulcer.

Abstract:

:The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the infection is especially indicated in complicated/recalcitrant ulcer disease. Sadly, at present only a minority of peptic ulcer disease patients receive adequate eradication therapy. Cure of the infection does not equal full resolution of dyspeptic symptoms. A variable percentage of patients continues acid suppressant therapy for ongoing or newly developed dyspeptic or reflux symptoms. Acid-suppressant therapy, both for healing and for maintenance, remains the cornerstone of peptic ulcer therapy in all other circumstances (H. pylori-negative ulcer, aspirin/NSAID-induced ulceration, hyperacidity related ulcer etc.). Proton pump inhibitors are superior to H2RAS both for healing and for maintenance. Whether higher doses are occasionally necessary in H. pylori-negative ulcers, requires further study. Acid-suppressant therapy, even when prolonged, so far appears safe and well tolerated.

journal_name

Digestion

journal_title

Digestion

authors

Tytgat GN

doi

10.1159/000007522

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

446-52

issue

5

eissn

0012-2823

issn

1421-9867

pii

dig59446

journal_volume

59

pub_type

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