Abstract:
:CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pirenzepine (selective muscarinic M1 receptor blocker) or atropine failed to affect the amylase responses to all these secretagogues except that to urecholine, which was reduced by both antimuscarinic agents. The inhibition of urecholine-induced half-maximal amylase secretion by both anticholinergics was concentration-dependent, and the inhibitory potency of pirenzepine was about 1,000 times lower than that of atropine.
journal_name
Digestionjournal_title
Digestionauthors
Jaworek J,Konturek SJdoi
10.1159/000199415subject
Has Abstractpub_date
1987-01-01 00:00:00pages
175-81issue
3eissn
0012-2823issn
1421-9867journal_volume
36pub_type
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