Effects of pirenzepine and atropine on amylase response to various secretagogues from the rat pancreatic acini.

Abstract:

:CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pirenzepine (selective muscarinic M1 receptor blocker) or atropine failed to affect the amylase responses to all these secretagogues except that to urecholine, which was reduced by both antimuscarinic agents. The inhibition of urecholine-induced half-maximal amylase secretion by both anticholinergics was concentration-dependent, and the inhibitory potency of pirenzepine was about 1,000 times lower than that of atropine.

journal_name

Digestion

journal_title

Digestion

authors

Jaworek J,Konturek SJ

doi

10.1159/000199415

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

175-81

issue

3

eissn

0012-2823

issn

1421-9867

journal_volume

36

pub_type

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