Somatostatin is an essential paracrine link in acid inhibition of gastrin secretion.

abstract：:In order to study some of the molecular events during the hepatic passage of gastrin, we perfused sulfated natural porcine gastrin (G17 II) through isolated pig livers. The disappearance half time of G17 II was about 20-30 min when the starting gastrin concentrations were greater than 100 pM; lower concentrations were...

journal_title：Digestion

authors： Feurle GE,Winkler C,Encke A,Helmstaedter V,Doertenbach JG

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) has become the standard endoscopic treatment for early gastric cancer without lymph node metastasis. At present, undifferentiated type intramucosal cancers without ulcer findings <20 mm in size are often chosen as endoscopic treatment lesions for expanded indication. Th...

journal_title：Digestion

authors： Kamada K,Tomatsuri N,Yoshida N

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Incidence of cholangiocarcinoma (CCA) in western countries is rising. In the palliative setting, chemotherapy is the only established treatment. The evidence for other treatments including locoregional therapy is low. However, such individual treatments are offered in a real-world setting. The aim of this st...

journal_title：Digestion

authors： Koch C,Franzke C,Bechstein WO,Schnitzbauer AA,Filmann N,Vogl T,Gruber-Rouh T,Zeuzem S,Waidmann O,Trojan J

更新日期：2020-01-01 00:00:00

abstract：:Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...

journal_title：Digestion

authors： Heim HK,Oestmann A,Thiele H,Sewing KF

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Different food items are made responsible for irritable bowel syndrome (IBS) symptoms, but the physiopathology of IBS remains unclear. AIMS:During a meeting in Nice, France, experts of the European Working Team of the IBiS Club discussed selected data regarding the relationships between alimentation, food i...

journal_title：Digestion

authors： Dapoigny M,Stockbrügger RW,Azpiroz F,Collins S,Coremans G,Müller-Lissner S,Oberndorff A,Pace F,Smout A,Vatn M,Whorwell P

更新日期：2003-01-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis represent distinct phenotypic forms of inflammatory bowel disease and continue to be a common cause of morbidity. The corticosteroids and the immunomodulatory drugs, which are the basis of treatment for the inflammatory bowel diseases, do not assure always satisfactory outcomes. ...

journal_title：Digestion

authors： Ioannidis O,Varnalidis I,Paraskevas G,Botsios D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:As opposed to regular C-reactive protein (CRP) assays, the introduction of high-sensitivity ones has enabled us to detect low grade inflammation in patients with inflammatory bowel disease (IBD). We addressed the subject of the degree of correlation between the concentration of high-sensitivity CRP (hs-...

journal_title：Digestion

authors： Zilberman L,Maharshak N,Arbel Y,Rogowski O,Rozenblat M,Shapira I,Berliner S,Arber N,Dotan I

更新日期：2006-01-01 00:00:00

abstract：:Growth hormone-releasing factor (GRF) was reported to possess the growth-promoting action on the gastroduodenal mucosa that can be augmented by removal of endogenous somatostatin. Since mucosal proliferation was considered to contribute to healing of chronic gastroduodenal ulcerations, we designed the study to determi...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Dembinski A,Warzecha Z,Konturek PK,Yanaihara N

更新日期：1988-01-01 00:00:00

abstract：:Rats were subjected to serial venesections 3 days prior to and then sequentially for 4 weeks after surgical removal of either the proximal or distal half of the small bowel. Total serum protein concentration and protein electrophoretic patterns were determined on these sera. Both sham-operated and unoperated animals s...

journal_title：Digestion

authors： Urban E,Ricks PM

更新日期：1980-01-01 00:00:00

abstract：:The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...

journal_title：Digestion

authors： Tanikawa M,Hayakawa T,Kondo T,Naruse S,Shibata T,Kitagawa M

更新日期：1994-01-01 00:00:00

abstract：:8 children, known to have been hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive for more than 6 months and with chronic active hepatitis on biopsy, received 2.5 mg levamisole/kg/day, 2 days a week for 6-18 months. In 6 of the 8 children transaminases normalized within 4-18 months of thera...

journal_title：Digestion

authors： Fattovich G,Cadrobbi P,Crivellaro C,Pornaro E,Alberti A,Realdi G

更新日期：1982-01-01 00:00:00

abstract：:The effects of secretin and caerulein on the absorption of water, sodium, potassium and glucose from the jejunum of dogs were investigated. Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period. Adding an intravenous ...

journal_title：Digestion

authors： Hirose S,Shimazaki K,Hattori N

更新日期：1986-01-01 00:00:00

abstract：:In 1905, John Edkins (1863-1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive pharmacological agents that have revolutionized the management of acid pept...

journal_title：Digestion

authors： Modlin IM,Sachs G,Wright N,Kidd M

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:The pathogenesis of dyspeptic/reflux symptoms and the clinico-pathologic profile of affected patients are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa i...

journal_title：Digestion

authors： Villani L,Trespi E,Fiocca R,Broglia F,Colla C,Luinetti O,Tinelli C,Solcia E

更新日期：1998-01-01 00:00:00

abstract：:Leucine absorption across the mechanically obstructed rat intestine was studied by in vivo and in vitro techniques. It varied between the early (after 2 h) and late (after 18 h) phases of the obstruction. During the early phase there was a reduction in mucosal uptake and in net absorption of the amino acid. At 18 h th...

journal_title：Digestion

authors： Hajjar JJ,Schwartz RG,Mirkin KR,Tomicic TK

更新日期：1982-01-01 00:00:00

abstract：INTRODUCTION:Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present st...

journal_title：Digestion

authors： Abe Y,Koike T,Saito M,Okata T,Nakagawa K,Hatta W,Asanuma K,Uno K,Asano N,Imatani A,Masamune A

更新日期：2020-02-14 00:00:00

abstract：:The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

journal_title：Digestion

authors： Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Duodenal cancer is one of the extracolonic malignancies with known mortality in familial adenomatous polyposis (FAP) patients. Visualization of the major duodenal papilla (MDP) with a standard esophagogastroduodenoscopy (EGD) is currently insufficient because of the limited field of view. Full-spect...

journal_title：Digestion

authors： Ichijima R,Abe S,Kobayashi S,Minagawa T,Tagawa T,Nakajima T,Yamada M,Takamaru H,Sekiguchi M,Sakamoto T,Oda I,Matsuda T,Saito Y,Gotoda T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal in...

journal_title：Digestion

authors： Brzozowski T,Konturek PC,Konturek SJ,Pierzchalski P,Bielanski W,Pajdo R,Drozdowicz D,Kwiecień S,Hahn EG

更新日期：2000-01-01 00:00:00

abstract：:The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg ...

journal_title：Digestion

authors： Lundell L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:People may have symptoms of multiple disorders at the same time. We aimed to determine prevalence and risk factors for overlaps between gastroesophageal reflux disease (GERD), dyspepsia and irritable bowel syndrome (IBS) in a Korean population. METHODS:A cross-sectional survey was performed on 1,688 ra...

journal_title：Digestion

authors： Lee SY,Lee KJ,Kim SJ,Cho SW

更新日期：2009-01-01 00:00:00

abstract：AIM:To evaluate number and quality of publications in gastroenterology, hepatology and digestive endoscopy from Western Europe (Belgium, Denmark, France, Germany, Great Britain, Italy, the Netherlands, Spain, Sweden, Switzerland), Japan and USA over a recent 5-year period. METHODS:We screened by computer for full live...

journal_title：Digestion

authors： Sorrentino D,De Biase F,Trevisi A,Bartoli E

更新日期：2000-01-01 00:00:00

abstract：:In an attempt to evaluate a possible correlation between cryptogenic chronic liver disease and a present or past hepatitis B virus (HBV) infection, we studied 17 patients with hepatitis B surface antigen (HBsAg)-negative, nonalcoholic chronic liver disease; 9 of them were positive for serum HBsAg detected by a solid-p...

journal_title：Digestion

authors： Diodati G,Pontisso P,Bonetti P,Stenico D,Noventa F,Alberti A,Realdi G

更新日期：1988-01-01 00:00:00

abstract：:To assess the sensitivity, specificity and clinical value of prealbumin as liver test, prealbumin plasma levels were measured in 100 patients with liver disease and in 65 patients without clinical evidence of liver impairment. The sensitivity of prealbuminemia was higher than that of albumin, pseudocholinesterase, apo...

journal_title：Digestion

authors： Rondana M,Milani L,Merkel C,Caregaro L,Gatta A

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Double-filtration plasmapheresis (DFPP) together with interferon (IFN) administration produces a substantial reduction in the viral load during the early stages of treatment. METHODS:Based on their responses to previous pegylated IFN and ribavirin (PEG-IFN/RBV) therapy, 20 patients were divided int...

journal_title：Digestion

authors： Kim SR,Saito J,Imoto S,Komaki T,Nagata Y,Kim KI,Sasase N,Kimura N,Sasatani K,Konishi E,Hasegawa Y,Fujinami A,Ohta M,El-Shamy A,Tanaka Y,Sugano M,Sakashita M,Nakamura A,Tsuchida S,Makino T,Kawada T,Nakajima T,M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...

journal_title：Digestion

authors： Fanti L,Mezzi G,Cavallero A,Gesu G,Bonato C,Masci E

更新日期：1999-09-01 00:00:00

abstract：:Groups of Sprague-Dawley rats were given placebo or prostaglandin E2 (PGE2) at 25 or 5,000 micrograms/kg or 15,R,15-methyl-PGE2 (MePGE2) at 5 or 50 micrograms/kg, twice daily, orally, for 1 month. Histological sections from the proximal duodenum were processed for immunohistochemistry and the volume density of immunor...

journal_title：Digestion

authors： Kapraali M,Söderman C,Marín L,Johansson O,Theodorsson E,Uribe A

更新日期：1997-01-01 00:00:00

abstract：:The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. During the active phase of the disease, the NO3 excretion was significantly higher in the patients than in healthy controls (n = 6, p < 0....

journal_title：Digestion

authors： Sasajima K,Yoshida Y,Yamakado S,Sato J,Miyashita M,Okawa K,Matsutani T,Onda M,Kawano E

更新日期：1996-01-01 00:00:00

abstract：:Fundic mucosal extracts of the cat were examined by chromatography using DEAE-cellulose at pH 5.3. The peaks of proteolytic activity located by this method were shown to be heterogeneous on electrophoresis. By electrophoresis of individual homogenous chromatographic fractions 9 separate zones of proteolytic activity w...

journal_title：Digestion

authors： Shaw B,Wright CL

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND/AIM:What naturally happens to patients after they undergo conservative and endoscopic treatment of colonic diverticular bleeding (CDB) is largely unknown. We retrospectively track the long-term outcome of the recurrence of CDB between patients with endoscopic and conservative treatment. METHODS:The group wa...

journal_title：Digestion

authors： Mizuki A,Tatemichi M,Nakazawa A,Tsukada N,Nagata H,Kanai T

更新日期：2016-01-01 00:00:00