Prevention of relapse of reflux oesophagitis after endoscopic healing: the efficacy and safety of omeprazole compared with ranitidine.

Abstract:

:The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg b.i.d. (n = 47), in the acute healing of reflux oesophagitis (90 and 47% healing, respectively; p less than 0.0001). Omeprazole, 20 mg o.m., is also far more effective than ranitidine, 150 mg b.i.d., in the maintenance treatment of these patients; 67% of the omeprazole-treated patients remained in clinical and endoscopic remission throughout the 12-month study period compared with only 10% of those given ranitidine (p less than 0.0001). This therapeutic advantage was achieved without adverse events and without significant abnormalities in the endocrine or exocrine cell population of the oxyntic mucosa. Basal serum gastrin levels were modestly raised after 4 weeks of omeprazole treatment (the change being from 8.6 to 16.9 pmol/l; p less than 0.05), and remained at this level throughout the study period.

journal_name

Digestion

journal_title

Digestion

authors

Lundell L

doi

10.1159/000200522

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

72-5

eissn

0012-2823

issn

1421-9867

journal_volume

47 Suppl 1

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Interdigestive gastrointestinal motility and secretion of gastric acid and pancreatic enzymes in young cigarette smokers.

    abstract::The basal (interdigestive) gastrointestinal motor activity and the interdigestive gastric acid and pancreatic amylase secretion were determined in 10 young smokers (mean age 23 years) and 7 nonsmokers (mean age 26 years). There was no significant difference in the length of the interdigestive motor complex between smo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199018

    authors: Demol P,Singer MV,Hotz J,Dipp M,Goebell H

    更新日期:1984-01-01 00:00:00

  • Computed tomographic colonography is valuable for post-treatment evaluation and screening of hidden colorectal cancer in patients with cryptogenic pyogenic liver abscess.

    abstract:BACKGROUND/AIMS:It has been demonstrated that cryptogenic pyogenic liver abscess (PLA) is associated with colonic mucosal defect, especially colorectal cancer (CRC). Therefore, the screening of CRC in patients with cryptogenic PLA is important. This study was to investigate whether computed tomographic colonography (CT...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000356534

    authors: Jang DK,Jeong SH,Lee SH,Lee M,Jang ES,Kim JW,Hwang JH,Ryu JK,Kim YT,Lee YJ,Lee KH,Kim YH

    更新日期:2014-01-01 00:00:00

  • In search of immunogenic Helicobacter pylori proteins by screening of expression library.

    abstract:BACKGROUND:Prevention of Helicobacter pylori infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no immunization protocol has been accepted for humans. A better characterization of the i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007731

    authors: Lazowska I,Trzeciak L,Godlewska R,Hennig E,Jagusztyn-Krynicka K,Popowski J,Regula J,Ostrowski J

    更新日期:2000-01-01 00:00:00

  • Omeprazole in the short-term treatment of reflux oesophagitis.

    abstract::Studies with short-term administration of omeprazole in patients with erosive or ulcerative reflux oesophagitis have demonstrated that strong inhibition of gastric acid secretion will become the therapy of choice for these patients. However, because reflux oesophagitis relapses rapidly when short-term treatment is dis...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200103

    authors: Jansen JB,Lamers CB

    更新日期:1989-01-01 00:00:00

  • Quantitative assessment of gastric antrum atrophy shows restitution to normal histology after Helicobacter pylori eradication.

    abstract:BACKGROUND/AIMS:Grading gastric mucosal atrophy in antrum biopsy specimens remains a controversial subject because of limitations in interobserver agreement. We previously described a reliable, quantitative method for grading atrophy of the corpus mucosa with excellent reproducibility and good correlation with the Sydn...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000076544

    authors: van Grieken NC,Meijer GA,Kale I,Bloemena E,Lindeman J,Offerhaus GJ,Meuwissen SG,Baak JP,Kuipers EJ

    更新日期:2004-01-01 00:00:00

  • Critical flicker frequency as a marker of hepatic encephalopathy in patients before and after transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000288522

    authors: Biecker E,Hausdörfer I,Grünhage F,Strunk H,Sauerbruch T

    更新日期:2011-01-01 00:00:00

  • The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000112646

    authors: Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

    更新日期:2007-01-01 00:00:00

  • Effects of gastric fundectomy and antrectomy on the colonic mucosa in the hamster.

    abstract::The effects of gastric fundectomy and antrectomy on the colonic mucosa were studied in hamsters over 5 and 25 days. Sham-operated animals served as controls. Basal plasma gastrin concentrations were significantly increased after fundectomy and significantly decreased after antrectomy. Five days after fundectomy, there...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200968

    authors: Chu M,Rehfeld JF,Borch K

    更新日期:1992-01-01 00:00:00

  • Plasmapheresis in Crohn's disease.

    abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198344

    authors: Holdstock GE,Fisher JA,Hamblin TJ,Loehry C

    更新日期:1979-01-01 00:00:00

  • Importance of plasma aldosterone concentration on the natriuretic effect of spironolactone in patients with liver cirrhosis and ascites.

    abstract::23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199198

    authors: Bernardi M,Servadei D,Trevisani F,Rusticali AG,Gasbarrini G

    更新日期:1985-01-01 00:00:00

  • Gastric cytoprotection by acetazolamide: role of endogenous prostaglandins.

    abstract::This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198975

    authors: Konturek SJ,Brzozowski T,Piastucki I,Radecki T

    更新日期:1983-01-01 00:00:00

  • Effects of proton pump inhibitors on pediatric inflammatory esophagogastric polyps.

    abstract:BACKGROUND:The aim of this study was to investigate the effects of proton pump inhibitors on symptomatic inflammatory esophagogastric polyps (IEPs) in a pediatric cohort and to determine the optimal duration of treatment. METHODS:The 11 patients with IEPs were managed with lansoprazole. Follow-up endoscopies were perf...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000327909

    authors: Choi KE,Kim MJ,Lee JH,Lee JS,Lee JH,Choe YH

    更新日期:2012-01-01 00:00:00

  • Adrenergic effects on secretion of amylase from the rat salivary glands.

    abstract::The present study was undertaken to investigate the effect of adrenergic agents on secretion of amylase from the salivary glands in vivo. Saliva was collected from the distal oesophagus in conscious rats. Adrenaline increased the concentration of amylase in saliva and serum significantly. The result of infusion of alp...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199729

    authors: Skov Olsen P,Kirkegaard P,Rasmussen T,Magid E,Poulsen SS,Nexø E

    更新日期:1988-01-01 00:00:00

  • Sleep dysfunction in Japanese patients with gastroesophageal reflux disease: prevalence, risk factors, and efficacy of rabeprazole.

    abstract:BACKGROUND AND AIM:Several studies performed in Western countries demonstrate the association between sleep dysfunction and gastroesophageal reflux disease (GERD), especially when nighttime heartburn is present. The purpose of this study was to examine the prevalence and risk factors of sleep dysfunction, and the effec...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000253849

    authors: Fujiwara Y,Kohata Y,Kaji M,Nebiki H,Yamasaki T,Sasaki E,Hayakawa T,Machida H,Tanigawa T,Watanabe K,Watanabe T,Tominaga K,Arakawa T

    更新日期:2010-01-01 00:00:00

  • Plaunotol stimulates endogenous secretin release and exocrine pancreatic secretion in rats.

    abstract::The effect of the new antiulcer agent plaunotol on the release of endogenous secretin and the pancreatic exocrine secretion was investigated in anesthetized rats. In 48 rats with pancreatic and biliary diversion, continuous intraduodenal infusion of plaunotol in 3 graded doses (5, 20 and 80 mg/h/rat) resulted in signi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199903

    authors: Chang JH,Watanabe S,Shiratori K,Moriyoshi Y,Takeuchi T

    更新日期:1989-01-01 00:00:00

  • Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes.

    abstract:BACKGROUND:The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM:To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS:Prepubertal children of ages 3-12 with either la...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000381895

    authors: Nwosu BU,Maranda L

    更新日期:2015-01-01 00:00:00

  • Gastrocnemius myositis in a patient with inflammatory bowel disease.

    abstract::A young woman with long-standing inflammatory bowel disease presented with a tender left gastrocnemius myositis in association with an exacerbation of her disease. Muscle biopsy showed a chronic inflammatory cell infiltrate and atrophic muscle fibres, but no granulomata or vasculitis, and her symptoms responded to hig...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199251

    authors: Hall MJ,Thomas WE,Cooper BT

    更新日期:1985-01-01 00:00:00

  • Endoscopic Evaluation of Neoadjuvant Chemotherapeutic Efficacy in Gastric Cancer before Gastrectomy Might be as Useful as Histological Assessment after Gastrectomy.

    abstract:BACKGROUND:Neoadjuvant chemotherapy for advanced gastric cancer is expected to improve prognoses. However, as there is no method to evaluate neoadjuvant chemotherapeutic efficacy before gastrectomy, some patients at high risk for a poor prognosis undergo gastrectomy. The aim of the present study was to investigate whet...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000500907

    authors: Sugawara N,Ota K,Terazawa T,Tanaka R,Akutagawa H,Yamaguchi T,Imai Y,Harada S,Kojima Y,Tashiro K,Kii T,Lee SW,Kawai M,Egashira Y,Goto M,Uchiyama K,Hirose Y,Takeuchi T,Higuchi K

    更新日期:2020-01-01 00:00:00

  • Cryptogenic chronic liver disease and serum or liver hepatitis B virus markers. Their possible correlations and etiologic significance.

    abstract::In an attempt to evaluate a possible correlation between cryptogenic chronic liver disease and a present or past hepatitis B virus (HBV) infection, we studied 17 patients with hepatitis B surface antigen (HBsAg)-negative, nonalcoholic chronic liver disease; 9 of them were positive for serum HBsAg detected by a solid-p...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199633

    authors: Diodati G,Pontisso P,Bonetti P,Stenico D,Noventa F,Alberti A,Realdi G

    更新日期:1988-01-01 00:00:00

  • Chemoprevention and Treatment of Pancreatic Cancer: Update and Review of the Literature.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY:Different risk factors like smoking or hereditary tumour syndromes should be...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000485741

    authors: Benzel J,Fendrich V

    更新日期:2018-01-01 00:00:00

  • Radiation pancreatitis: a clinical entity?

    abstract::2 cases of pancreatic disease in patients with malabsorption following small bowel radiation injury are reported. It is suggested that the pancreatic disease present in these patients occurred as a result of previous radiotherapy. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198334

    authors: Mitchell CJ,Simpson FG,Davison AM,Losowsky MS

    更新日期:1979-01-01 00:00:00

  • Trends in pre-liver transplant screening for cholangiocarcinoma among patients with primary sclerosing cholangitis.

    abstract:BACKGROUND:Cholangiocarcinoma (CCA) is the most common hepatobiliary malignancy complicating primary sclerosing cholangitis (PSC). Unfortunately, timely diagnosis of CCA in PSC patients remains challenging. AIM:To investigate the strategies among liver centers regarding pre-transplant screening for CCA in patients wit...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000357445

    authors: Trilianos P,Selaru F,Li Z,Gurakar A

    更新日期:2014-01-01 00:00:00

  • A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan.

    abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000507570

    authors: Kudo T,Fujii T,Maisawa SI,Sasaki M,Uchida K,Ida S,Kagimoto S,Yoden A,Shimizu T

    更新日期:2020-05-18 00:00:00

  • Zinc deficiency in Crohn's disease.

    abstract::Zinc nutriture has been studies in 30 patients with Crohn's disease using plasma zinc, hair zinc, and taste acuity as indices. Significant reductions in plasma zinc concentrations and taste acuity were seen in the patient groups as compared with normal controls. Hair zinc content was also generally low with several de...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198059

    authors: Solomons NW,Rosenberg IH,Sandstead HH,Vo-Khactu KP

    更新日期:1977-01-01 00:00:00

  • Adrenergic and cholinergic interactions in rat gastric somatostatin and gastrin release.

    abstract::The interactions of adrenergic and cholinergic influences on the gastric D cell were studied using an isolated perfused rat stomach in vitro. The sevenfold increase in the release of somatostatin-like immunoreactivity (SLI) in response to isoproterenol (4 . 10(-8) M) was dose-dependently inhibited by acetylcholine (10...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198817

    authors: Koop H,Behrens I,Bothe E,McIntosh CH,Pederson RA,Arnold R,Creutzfeldt W

    更新日期:1982-01-01 00:00:00

  • Polyamine uptake across the basolateral membrane of the enterocyte is mediated by a high-affinity carrier: a study using isolated basolateral membrane vesicles.

    abstract:BACKGROUND/AIMS:Polyamine uptake from the circulation plays an important role in the maintenance of the intracellular polyamine content during extensive proliferation in intestinal mucosal cells. METHODS:Isolated basolateral membrane vesicles of the rabbit enterocyte were used to characterize polyamine transport acros...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007468

    authors: Milovic V,Caspary WF,Stein J

    更新日期:1998-01-01 00:00:00

  • Functional changes of the exocrine perfused rat pancreas in cerulein-induced pancreatitis.

    abstract::Functional changes of the exocrine pancreas in cerulein-induced pancreatitis were evaluated with the isolated perfused rat pancreas. In control specimens (n = 7), baseline pancreatic juice volume was 0.23 +/- 0.06 microliter/min and after stimulation with CCK-8 (10(-10) M) and secretin (10(-10) M), it was 2.26 +/- 0.4...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200879

    authors: Ando K,Manabe T,Kyogoku T,Ohshio G,Yotsumoto F,Tamura K,Imanishi K,Yositomi S,Tobe T

    更新日期:1992-01-01 00:00:00

  • Effect and safety of granulocyte-monocyte adsorption apheresis for patients with ulcerative colitis positive for cytomegalovirus in comparison with immunosuppressants.

    abstract:BACKGROUND:Cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies (IMT). However, the underlying UC remained active in some UC patients, despite the fact that CMV-DNA in colonic mucosa became negative after antiviral therapy. Therefore, new therapeutic strategies f...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000321911

    authors: Yoshino T,Nakase H,Matsuura M,Matsumura K,Honzawa Y,Fukuchi T,Watanabe K,Murano M,Tsujikawa T,Fukunaga K,Matsumoto T,Chiba T

    更新日期:2011-01-01 00:00:00

  • Effect of fasting and refeeding on basolateral polyamine uptake and metabolism by the rat small bowel.

    abstract::Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200737

    authors: Bardócz S,Grant G,Brown DS,Ewen SW,Stewart JC,Pusztai A

    更新日期:1991-01-01 00:00:00

  • Incorporation of N-acetyl-[14C]D-glucosamine and [3H]L-leucine by isolated pig gastric mucosal cells.

    abstract::Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199889

    authors: Heim HK,Oestmann A,Thiele H,Sewing KF

    更新日期:1989-01-01 00:00:00