Abstract:
BACKGROUND/AIMS:As opposed to regular C-reactive protein (CRP) assays, the introduction of high-sensitivity ones has enabled us to detect low grade inflammation in patients with inflammatory bowel disease (IBD). We addressed the subject of the degree of correlation between the concentration of high-sensitivity CRP (hs-CRP) and the inflammatory IBD activity score. METHODS:Included were 90 patients with Crohn's disease (CD), 70 with ulcerative colitis (UC) and 160 controls. Disease activity was determined using CD activity index (CDAI) for CD and Mayo score for UC. The Dade Boering BNII Nephelometer was used to determine the hs-CRP concentrations. RESULTS:The coefficient of correlation between hs-CRP and the disease activity score was similar for both UC (0.26) and CD (0.36). CONCLUSIONS:These findings are relevant for therapeutic intervention in which a greater absolute reduction in the hs-CRP concentration in CD patients (who generally present higher CRP concentrations than those found in UC) might be interpreted as a better response compared to the same absolute reduction in UC patients. This information is needed for clinicians using the hs-CRP assay to estimate IBD disease activity in daily practice.
journal_name
Digestionjournal_title
Digestionauthors
Zilberman L,Maharshak N,Arbel Y,Rogowski O,Rozenblat M,Shapira I,Berliner S,Arber N,Dotan Idoi
10.1159/000094531subject
Has Abstractpub_date
2006-01-01 00:00:00pages
205-9issue
4eissn
0012-2823issn
1421-9867pii
94531journal_volume
73pub_type
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