Abstract:
BACKGROUND AND AIMS:There are limited data concerning the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) after double-balloon endoscopy (DBE). The aim of the present study was to evaluate the long-term outcome of patients with OGIB after DBE. PATIENTS AND METHODS:Eighty-seven consecutive patients with OGIB (47 men and 40 women; mean age 65.3 years) underwent DBE between July 2006 and December 2009. The criteria for assessment included documented iron deficiency anemia/occult or obscure small intestinal bleeding, and overt small intestinal bleeding. They were followed for a mean period of 41.4 months after DBE, and were divided into two groups according to their outcome, that is a good clinical course group (GC group) and a poor clinical course group (PC group). The clinical characteristics associated with rebleeding after DBE were analyzed by comparison of these two groups. RESULTS:The source of bleeding was identified in 40 patients (46.0%) and endoscopic treatment was required in 21 of them (52.5%). The most frequent source of bleeding was ulcers/erosions (18.4%). During the follow-up period, 39 patients (44.8%) experienced bleeding and/or persistent iron deficiency anemia after DBE, while 48 patients did not. There were no significant differences of clinical characteristics between the two groups. However, there were more patients with diverticular bleeding in the GC group than the PC group, and there were significantly more patients with treatable small intestinal tumors/polyps in the GC group. There were also more patients with normal DBE findings in the GC group. CONCLUSION:This study demonstrated that the rebleeding rate after DBE varies depending on the source of bleeding.
journal_name
Digestionjournal_title
Digestionauthors
Fujita M,Manabe N,Honda K,Tarumi K,Murao T,Katada S,Kimura Y,Matsumoto H,Kamada T,Shiotani A,Hata J,Haruma Kdoi
10.1159/000313360subject
Has Abstractpub_date
2010-01-01 00:00:00pages
173-8issue
3eissn
0012-2823issn
1421-9867pii
000313360journal_volume
82pub_type
杂志文章相关文献
DIGESTION文献大全abstract::Growth hormone-releasing factor (GRF) was reported to possess the growth-promoting action on the gastroduodenal mucosa that can be augmented by removal of endogenous somatostatin. Since mucosal proliferation was considered to contribute to healing of chronic gastroduodenal ulcerations, we designed the study to determi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199763
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND/AIMS:We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD). METHODS:Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administere...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201486
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:gamma delta T cell populations are well-known for their unique distribution (e.g. intra-epithelial lymphocytes). Though their ligands play a major role in the immune response they have remained largely obscure. To shed light on this issue, we have analyzed in this study the complementarity det...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051911
更新日期:2001-01-01 00:00:00
abstract::At 1 year after a first resection, up to 80% of patients show an endoscopic recurrence, 10-20% have clinical relapse, and 5% have surgical recurrence. Smoking is one of the most important risk factors for postoperative recurrence. Preoperative disease activity and the severity of endoscopic lesions in the neoterminal ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000083873
更新日期:2005-01-01 00:00:00
abstract::Crohn's disease and ulcerative colitis represent distinct phenotypic forms of inflammatory bowel disease and continue to be a common cause of morbidity. The corticosteroids and the immunomodulatory drugs, which are the basis of treatment for the inflammatory bowel diseases, do not assure always satisfactory outcomes. ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000323456
更新日期:2011-01-01 00:00:00
abstract::Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/o...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000111486
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected in...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000479000
更新日期:2017-01-01 00:00:00
abstract::Eighteen cases of severe hyperplasia of fundic argyrophil cells observed during routine histologic examination of endoscopic gastric biopsy specimens from unselected patients with upper gastro-intestinal symptomatology were investigated. All patients, except one, were female with a mean age of 57 years. Atrophic gastr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199389
更新日期:1986-01-01 00:00:00
abstract::The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201168
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND/AIMS:Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS. METHODS:IBS patients of the diarr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000333083
更新日期:2012-01-01 00:00:00
abstract::There is no generally accepted treatment in the irritable bowel syndrome (IBS), probably because of a lack of convincing therapeutic trials. In the present study, 120 outpatients with IBS participated in a prospective randomized therapeutic trial. According to a double-blind design, 40 patients received 400 mg/day meb...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000199329
更新日期:1986-01-01 00:00:00
abstract::Outpatient treatment of haemorrhoids by elastic band ligation without anaesthetic was performed in 75 patients. Clinical review showed that 65 returned to work within 24 h of ligation, 8 in 48 h and 2 after 48 h. No patient required hospitalisation for either rectal bleeding or pain after ligation. In the first week a...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197658
更新日期:1975-01-01 00:00:00
abstract::The activity of platelet-activating factor (PAF) acetylhydrolase in biopsy specimens of intestinal mucosa was compared in patients with Crohn's disease (n = 11) and controls (n = 6). In addition, PAF acetylhydrolase activity was determined in the plasma of Crohn patients (n = 30) and healthy subjects (n = 35). The act...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201376
更新日期:1996-11-01 00:00:00
abstract::Patients with moderate-to-severe disease and patients with steroid-refractory or steroid-dependent disease differ in their management, as the latter two groups usually involve patients whose condition is less acute. Systemic corticosteroids represent the mainstay of the management of moderate-to-severe disease and rem...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000111023
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy for advanced gastric cancer is expected to improve prognoses. However, as there is no method to evaluate neoadjuvant chemotherapeutic efficacy before gastrectomy, some patients at high risk for a poor prognosis undergo gastrectomy. The aim of the present study was to investigate whet...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000500907
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but als...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000484043
更新日期:2017-11-01 00:00:00
abstract::We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201406
更新日期:1996-01-01 00:00:00
abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198344
更新日期:1979-01-01 00:00:00
abstract::Synthetic glucocorticoids, such as dexamethasone, and diets enriched with unsaturated fatty acids have been shown to stimulate hepatic bile salt synthesis. This fact led us to investigate the effects of dexamethasone and linoleic acid supplementation on bile secretion. Cholesterol (Ch) and phospholipid secretions are ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007700
更新日期:1999-11-01 00:00:00
abstract::The effects of secretin and caerulein on the absorption of water, sodium, potassium and glucose from the jejunum of dogs were investigated. Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period. Adding an intravenous ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199369
更新日期:1986-01-01 00:00:00
abstract::This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198975
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND AND AIM:A recent basic study identified that Dicer is contained in exosomes derived from cancer cells and plays crucial roles in microRNA maturation and cancer development. Based on this novel basic concept, we analyzed the usefulness of serum exosomal Dicer as a diagnostic biomarker for gastrointestinal can...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510993
更新日期:2020-10-13 00:00:00
abstract::Intestinal absorption after extensive small bowel resections, for diseases other than Crohn's disease, was studied in 17 patients. When the ileocecal valve and the right colon were preserved, malabsorption was transient and moderate and had no prejudicial nutritional effect (fecal fat: 8.8 +/- 1.8 g/24 h in resections...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198220
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:The importance of microbiota infiltrating the gut mucus layer has been reported in the pathogenesis of various gastrointestinal and systemic diseases. However, little is known about the mucosa-associated microbiota (MAM) in healthy subjects. The present study aimed to clarify the characteristics of the gastr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000496102
更新日期:2020-01-01 00:00:00
abstract::The effect of intercurrent diarrhoea on relapse of ulcerative colitis was investigated. Diarrhoea resulting from travel abroad, gastroenteritis or antibiotic usage resulted in an approximately 50% relapse rate. With regard to colonoscopy and barium enema, only the latter was followed by relapse and this may reflect di...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198896
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIMS:We investigated the effects of indomethacin and rebamipide on the gut microbiota profiles using terminal restriction fragment polymorphism (T-RFLP) analysis. MATERIALS AND METHODS:Female C57BL/6J mice were given indomethacin (10 mg/kg, s.c.) once a day and 2.5 mg rebamipide orally 3 times a day. After ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000341508
更新日期:2012-01-01 00:00:00
abstract::Rats were subjected to serial venesections 3 days prior to and then sequentially for 4 weeks after surgical removal of either the proximal or distal half of the small bowel. Total serum protein concentration and protein electrophoretic patterns were determined on these sera. Both sham-operated and unoperated animals s...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198408
更新日期:1980-01-01 00:00:00
abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000199876
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Human colorectal neuroendocrine cell carcinoma (NEC) is a rare disease with a poor prognosis. The biological behavior of NEC remains poorly understood. MATERIALS AND METHODS:We established two new NEC cell lines from a patient with rectal neuroendocrine carcinoma, NECS-P and NECS-L from the primary tumor an...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007825
更新日期:2000-01-01 00:00:00
abstract::The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199491
更新日期:1987-01-01 00:00:00