Abstract:
BACKGROUND/AIMS:We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD). METHODS:Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administered intraluminally via anus once a day. The rats were killed after 7 days for assessment of colonic damage by the colonic damage score. RESULTS AND CONCLUSION:ONO-NT-126 markedly reduced the colonic damage. Our findings suggest that the thromboxane-thromboxane receptor system plays an important role in this model of IBD and that antagonism of the thromboxane A2 receptor may prove useful for the treatment of IBD.
journal_name
Digestionjournal_title
Digestionauthors
Taniguchi T,Tsukada H,Nakamura H,Kodama M,Fukuda K,Tominaga M,Seino Ydoi
10.1159/000201486subject
Has Abstractpub_date
1997-01-01 00:00:00pages
476-8issue
5eissn
0012-2823issn
1421-9867journal_volume
58pub_type
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