Prospective evaluation of pain in exocrine pancreatic cancer.

abstract：:The effects of rioprostil (a newly developed synthetic prostaglandin E1 analogue) on meal-stimulated gastric acid secretion was evaluated in 8 healthy human volunteers. Gastric acid output was measured by intragastric titration on 4 different occasions. The following procedure was invariably employed: after a basal pe...

journal_title：Digestion

authors： Schulte K,Singer MV,Eysselein V,Demol P,Goebell H

更新日期：1987-01-01 00:00:00

abstract：:The effect of maximal doses of cholecystokinin and caerulein on lipase and chymotropsin concentrations were compared in large groups of patients with almost equal capacities of bicarbonate secretion. The responsiveness of the pancreas is, as a whole, higher with caerulein than with cholecystokinin, this feature being ...

journal_title：Digestion

authors： Minaire Y,Descos L

更新日期：1977-01-01 00:00:00

abstract：:CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...

journal_title：Digestion

authors： Jaworek J,Konturek SJ

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...

journal_title：Digestion

authors： Corpe C,Sreenan S,Burant C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The frequency of benign stenosis in ulcerative colitis (UC) is low, reported as being 3.2-11.2%, with fibrosis in the submucosa or deeper pointed out as one of the causes. The aim of the present study was to assess stenosis in UC cases using immunostaining and to analyze differences between stenotic...

journal_title：Digestion

authors： Yamagata M,Mikami T,Tsuruta T,Yokoyama K,Sada M,Kobayashi K,Katsumata T,Koizumi W,Saigenji K,Okayasu I

更新日期：2011-01-01 00:00:00

abstract：:In chronic pancreatitis the exocrine pancreatic tissue is replaced by extracellular matrix deposits from fibroblasts. We have stimulated fibrogenesis in the pancreas by inducing a single episode of cerulein pancreatitis (10 microg/kg/h for 12 h). We have used a spectrophotometrical assay to measure the tissue hydroxyp...

journal_title：Digestion

authors： Weidenbach H,Lerch MM,Turi S,Bachem M,Adler G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...

journal_title：Digestion

authors： Sakai M,Sohda M,Saito H,Ubukata Y,Nakazawa N,Kuriyama K,Hara K,Sano A,Ogata K,Yokobori T,Kuwano H,Shirabe K,Saeki H

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...

journal_title：Digestion

authors： Hollenbach M,Feisthammel J,Mössner J,Hoffmeister A

更新日期：2018-01-01 00:00:00

abstract：:To assess the sensitivity, specificity and clinical value of prealbumin as liver test, prealbumin plasma levels were measured in 100 patients with liver disease and in 65 patients without clinical evidence of liver impairment. The sensitivity of prealbuminemia was higher than that of albumin, pseudocholinesterase, apo...

journal_title：Digestion

authors： Rondana M,Milani L,Merkel C,Caregaro L,Gatta A

更新日期：1987-01-01 00:00:00

abstract：:Mechanisms of antisecretory action of intragastric FPL-52694, a mast cell stabilizer, were investigated in anesthetized rats. In Schild's rat preparation, intravenous FPL-52694 (10 mg/kg) significantly suppressed acid secretion in response to only tetragastrin (20 micrograms/kg, i.v.) (42.1 +/- 19.4%), while intragast...

journal_title：Digestion

authors： Takeuchi K,Ueki S,Okabe S

更新日期：1986-01-01 00:00:00

abstract：:Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...

journal_title：Digestion

authors： Pointner H,Kletter K

更新日期：1980-01-01 00:00:00

abstract：AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

journal_title：Digestion

authors： Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

更新日期：2001-01-01 00:00:00

abstract：:One to four months after implantation of a gastric fistula, a circadian rhythm in gastric acidity could be demonstrated by use of the intragastric 24-hour pH-metry in dogs with the gastric fistula protruding on the left side of the upper abdomen. This circadian rhythm was found to be fully developed within 3 years, an...

journal_title：Digestion

authors： Postius S,Bräuer U

更新日期：1995-01-01 00:00:00

abstract：:The effects of somatostatin on cholera toxin-induced secretory diarrhea and the appearance of glycoenzymes in the intestinal lumen and intestinal lymph were investigated in rat small intestine. After exposure to cholera toxin, marked fluid accumulation in the small intestinal tract and elevation of the jejunal mucosal...

journal_title：Digestion

authors： Yoshioka M,Asakura H,Hamada Y,Miura S,Kobayashi K,Morishita T,Morita A,Tsuchiya M

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric ca...

journal_title：Digestion

authors： Hiramatsu Y,Takeuchi H,Goto O,Kikuchi H,Kitagawa Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acotiamide, a prokinetic drug, is used to treat functional dyspepsia (FD), especially postprandial distress syndrome (PDS). However, a treatment for FD patients with PDS and/or epigastric pain syndrome (EPS) has not been established. We investigated the efficacy of famotidine in combination with acotiam...

journal_title：Digestion

authors： Hojo M,Nagahara A,Asaoka D,Takeda T,Izumi K,Matsumoto K,Ueyama H,Shimada Y,Matsumoto K,Nojiri S,Watanabe S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Transgenic mice overexpressing hepatitis B x protein (HBx) show an increased susceptibility to mutations if exposed to mutagens. Also involved in HBx signalling, reactive oxygen intermediates (ROI) can induce DNA adducts such as 8-hydroxy-2'-deoxyguanosine that can in turn lead to G/T transversion mutat...

journal_title：Digestion

authors： Gehrke R,Brauchle MA,Reifenberg K,Hildt E,Gruetzner U,Schmitz V,Schlicht HJ,Hofschneider PH,Caselmann WH,Rabe C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Some minimal changes (MCs) are believed to have a certain relationship with gastroesophageal reflux (GERD). Nonetheless, the individual meaning of MC is still unclear. Our aim was to compare the overall and individual prevalence of MC between patients with non-erosive reflux disease (NERD) and healthy c...

journal_title：Digestion

authors： Kim JB,Shin SR,Shin WG,Choi MH,Jang HJ,Kim KO,Park CH,Baek IH,Baik GH,Kim KH,Park SH,Kae SH,Lee MS,Kim HY

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Supramaximal concentrations of cholecystokinin (CCK) or cerulein induce the intracellular activation of trypsinogen and the transcription factor NF-kappaB, a key regulator of inflammatory gene expression. Both events occur early in the development of an acute pancreatitis. The aim of this study was ...

journal_title：Digestion

authors： Tando Y,Algül H,Schneider G,Weber CK,Weidenbach H,Adler G,Schmid RM

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...

journal_title：Digestion

authors： Konturek PC,Jaworek J,Maniatoglou A,Bonior J,Meixner H,Konturek SJ,Hahn EG

更新日期：2002-01-01 00:00:00

abstract：:Activation of enzyme phospholipase A2 (EC 3.1.1.4), the major liberator of arachidonic acid, has been proposed as a component in the pathogenesis of inflammatory bowel disease. To test the hypothesis that phospholipase A2 activity is increased in ulcerative colitis, enzyme activity was investigated in colonic biopsies...

journal_title：Digestion

authors： Almer S,Franzén L,Olaison G,Smedh K,Ström M

更新日期：1991-01-01 00:00:00

abstract：:Life-long administration (greater than or equal to 2 years) of a number of long-acting gastric acid inhibitors (including H2-receptor antagonists, omeprazole and ciprofibrate) has been associated with the development of gastric enterochromaffin-like cell (ECL cell) carcinoids in rats. It has been postulated that they ...

journal_title：Digestion

authors： Carlsson E,Havu N,Mattsson H,Ekman L

更新日期：1990-01-01 00:00:00

abstract：:The incidence of steatorrhea is said to be lower and its grade milder in Japanese because their fat intake is lower than that of Europeans and Americans. Failure to take this into account creates difficulties when attempting to compare data on pancreatic exocrine insufficiency in different countries. The authors exami...

journal_title：Digestion

authors： Nakamura T,Tando Y,Yamada N,Watanabe T,Ogawa Y,Kaji A,Imamura K,Kikuchi H,Suda T

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...

journal_title：Digestion

authors： Li M,Oshima T,Ito C,Yamada M,Tomita T,Fukui H,Miwa H

更新日期：2019-09-18 00:00:00

abstract：:The effect of feeding an alpha-amylase inhibitor (BAY e 4609, 700 mg/100 g food) for 20 or 90 days on the enzymes of the exocrine pancreas of the rat was investigated. The amylase inhibitor-fed rats gained significantly less weight despite a higher food intake than control rats on a standard diet. Fecal weight increas...

journal_title：Digestion

authors： Fölsch UR,Grieb N,Caspary WF,Creutzfeldt W

更新日期：1981-01-01 00:00:00

abstract：:Recent studies have demonstrated the presence of both CCKA and CCKB receptors on dog and guinea pig pancreas. Although CCKA receptors are implicated in enzymatic secretion, biological effects of CCKB receptors are still unknown. We have previously found that a rat acinar pancreatic cell line (AR4-2J) possesses both re...

journal_title：Digestion

authors： Seva C,De Vries L,Scemama JL,Sarfati P,Nicolet TG,Pradayrol L,Vaysse N

更新日期：1990-01-01 00:00:00

abstract：:In the dog pancreas in vivo, the biological activity of secretin and vasoactive intestinal peptide was compared to that of secretin analogues modified in their N-terminal hexapeptide and to X-secretion (alpha, beta-Asp3-secretin) and Y-secretin (a conversion product of X-secretin consisting of about 15% secretin and 8...

journal_title：Digestion

authors： Lehnert P,Forell MM,Jaeger E,Moroder L,Wünsch E

更新日期：1981-01-01 00:00:00

abstract：:Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...

journal_title：Digestion

authors： Reuber MD

更新日期：1976-01-01 00:00:00

abstract：:We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection technique was used to quantitate mitosis in duodenal crypts at the ulcer edge, giving a regeneration ind...

journal_title：Digestion

authors： Levi S,Goodlad RA,Lee CY,Stamp G,Walport MJ,Wright NA,Hodgson HJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal in...

journal_title：Digestion

authors： Brzozowski T,Konturek PC,Konturek SJ,Pierzchalski P,Bielanski W,Pajdo R,Drozdowicz D,Kwiecień S,Hahn EG

更新日期：2000-01-01 00:00:00