Mechanisms of antisecretory action of intragastric FPL-52694: a mast cell stabilizer in anesthetized rats.

abstract：:Familial colorectal cancer (CRC) is heterogeneous. Screening recommendations do exist for individuals with a mild to moderate family history of CRC, with or without early age at onset. However, most attention has properly focused on the identification of individuals in whom a defined susceptibility gene mutation can b...

journal_title：Digestion

authors： Lynch PM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocyt...

journal_title：Digestion

authors： Ashraf H,Beltinger J,Alam NH,Bardhan PK,Faruque AS,Akter J,Salam MA,Gyr N

更新日期：2007-01-01 00:00:00

abstract：:This study evaluated the effect of a cellulose meal and a cellulose-oleic acid meal on gastroduodenal motility and gastric emptying. The cellulose meal produced a high antral motility index (100 +/- 34 V/10 min) and a high proportion (80.2%) of propulsive duodenal contractions. The oleic acid meal was associated with ...

journal_title：Digestion

authors： Schemann M,Ehrlein HJ

更新日期：1982-01-01 00:00:00

abstract：:OctreoTher ((90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide, a.k.a. (90)Y-SMT 487) consists of a somatostatin peptide analogue (Tyr(3)-octreotide), coupled with a complexing moiety (DOTA), and labeled with a tightly bound beta-emitter (yttrium-90). By targeting somatostatin receptor-positive tumors (as imaged by OctreaScan it m...

journal_title：Digestion

authors： Smith MC,Liu J,Chen T,Schran H,Yeh CM,Jamar F,Valkema R,Bakker W,Kvols L,Krenning E,Pauwels S

更新日期：2000-01-01 00:00:00

abstract：:Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...

journal_title：Digestion

authors： Rune S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:It has been demonstrated that cryptogenic pyogenic liver abscess (PLA) is associated with colonic mucosal defect, especially colorectal cancer (CRC). Therefore, the screening of CRC in patients with cryptogenic PLA is important. This study was to investigate whether computed tomographic colonography (CT...

journal_title：Digestion

authors： Jang DK,Jeong SH,Lee SH,Lee M,Jang ES,Kim JW,Hwang JH,Ryu JK,Kim YT,Lee YJ,Lee KH,Kim YH

更新日期：2014-01-01 00:00:00

abstract：:Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient and the provider. The American Society of Anesthesiologists h...

journal_title：Digestion

authors： Paspatis GA,Tribonias G,Paraskeva K

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...

journal_title：Digestion

authors： Li M,Oshima T,Ito C,Yamada M,Tomita T,Fukui H,Miwa H

更新日期：2019-09-18 00:00:00

abstract：:Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivi...

journal_title：Digestion

authors： Murphy RF,Chen MH,Herlin PM,Gallavan RH,Joffe SN,Fischer JE

更新日期：1985-01-01 00:00:00

abstract：:Functional digestive disorders constitute one of the main causes of consultation in gastroenterology and primary health care. Is still unclear whether therapy has to be aimed to the gut, to the neural pathways controlling bowel motility and perception, or to the processing mechanisms of symptoms and disease behaviour....

journal_title：Digestion

authors： Mearin F

更新日期：2006-01-01 00:00:00

abstract：UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethano...

journal_title：Digestion

authors： Konturek SJ,Robert A

更新日期：1982-01-01 00:00:00

abstract：:The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...

journal_title：Digestion

authors： Meyer T,Brinck U

更新日期：1999-01-01 00:00:00

abstract：:108 adult patients and 34 children with chronic active hepatitis (CAH) are divided in four groups on the basis of presence and absence of hepatitis B surface antigen (HBsAg) and autoantibodies (AutoAb). There are significant differences in the numeric distribution among the four groups and the sex distribution between...

journal_title：Digestion

authors： Freudenberg J,Baumann H,Arnold W,Berger J,Büschenfelde KH

更新日期：1977-01-01 00:00:00

abstract：:We describe a patient with relapses of Clostridium difficile cytotoxin-positive pseudomembranous colitis (PMC) after treatment with vancomycin, a course of metronidazole and a trial of bacitracin. She remains free of disease after a prolonged course of cholestyramine. We suggest there may be a role for anion-exchange ...

journal_title：Digestion

authors： Kunimoto D,Thomson AB

更新日期：1986-01-01 00:00:00

abstract：:The effects of rioprostil (a newly developed synthetic prostaglandin E1 analogue) on meal-stimulated gastric acid secretion was evaluated in 8 healthy human volunteers. Gastric acid output was measured by intragastric titration on 4 different occasions. The following procedure was invariably employed: after a basal pe...

journal_title：Digestion

authors： Schulte K,Singer MV,Eysselein V,Demol P,Goebell H

更新日期：1987-01-01 00:00:00

abstract：:Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...

journal_title：Digestion

authors： Bardócz S,Grant G,Brown DS,Ewen SW,Stewart JC,Pusztai A

更新日期：1991-01-01 00:00:00

abstract：:The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...

journal_title：Digestion

authors： Lepoutre L,Van der Spek P,Vanderlinden I,Bollen J,Laukens P

更新日期：1990-01-01 00:00:00

abstract：:Mortality data for ulcerative colitis, Crohn's disease, and unspecified inflammatory bowel disease were examined for the countries Venezuela, Italy, and France during the decade 1969-1978. These figures were compared with similar data from England and Wales obtained from 1965 to 1975. In Italy and France deaths from C...

journal_title：Digestion

authors： D'Oliveira R,Mayberry JF,Newcombe RG,Rhodes J

更新日期：1984-01-01 00:00:00

abstract：:Leukocytapheresis has recently been used to induce remission in patients with ulcerative colitis (UC) who fail to respond to corticosteroids. We could not find a report in the literature on leukocytapheresis for UC with gestational exacerbation. We have recently encountered this unique condition and report the details...

journal_title：Digestion

authors： Okada H,Makidono C,Takenaka R,Hiraoka S,Fujiwara A,Kato J,Kawahara Y,Kawamoto H,Mizuno M,Shiratori Y

更新日期：2006-01-01 00:00:00

abstract：:Electroencephalographic tracings of 50 patients with ulcerative colitis (UC) were compared with those of 75 controls. In the UC patients a 24% incidence of abnormal tracings was found as compared with an 8% incidence in the controls. A higher incidence of abnormal electroencephalograms was found among active cases of ...

journal_title：Digestion

authors： Eschar J,Arlazoroff A,Kleinhaus M,Mera A,Gilat T,Weissman I

更新日期：1975-01-01 00:00:00

abstract：:We have followed the time-course of the morphological and functional recovery of intestinal mucosa after 90 min of mesenteric vascular occlusion. At the end of the ischemic period the villi were smashed, but crypts were preserved. Microvillous hydrolase activities showed a dramatic drop when compared with sham-operate...

journal_title：Digestion

authors： Kummerlen C,Seiler N,Galluser M,Gossé F,Knodgen B,Hasselmann M,Raul F

更新日期：1994-01-01 00:00:00

abstract：:The clinical value of the tumor marker human chorionic gonadotropin-beta (hCG-beta) in ascitic fluid for the differentiation of malignancy-related and non-malignant ascites was evaluated. Ascitic fluid protein, cholesterol and cytological examination were determined for comparison. Thirty-six patients with malignancy-...

journal_title：Digestion

authors： Gerbes AL,Hoermann R,Mann K,Jüngst D

更新日期：1996-01-01 00:00:00

abstract：:Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, ...

journal_title：Digestion

authors： Simon B,Kather H

更新日期：1977-01-01 00:00:00

abstract：:High-fidelity simulation uses simulators that combine all of the physiological and pharmacological responses of a human in a manikin. These simulators change and respond to the users and trainees. Using simulators for teaching sedation in the field of gastroenterology unifies all the advantages of manikins. To underst...

journal_title：Digestion

authors： Hofmann N,Datz C,Schöchl H

更新日期：2010-01-01 00:00:00

abstract：:We studied the functional coupling between antral somatostatin and gastrin cells in pigs using isolated perfused preparations of the antrum with intact supply of the vagus nerves. Luminal acidification significantly inhibited gastrin secretion to 61 +/- 3% of basal secretion and increased somatostatin output 9-fold. I...

journal_title：Digestion

authors： Holst JJ,Orskov C,Seier-Poulsen S

更新日期：1992-01-01 00:00:00

abstract：:CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...

journal_title：Digestion

authors： Jaworek J,Konturek SJ

更新日期：1987-01-01 00:00:00

abstract：:6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...

journal_title：Digestion

authors： Holdstock GE,Fisher JA,Hamblin TJ,Loehry C

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to compare the accuracy of magnifying endoscopy with narrow band imaging for the diagnosis of depth of invasion by Japan Esophageal Society (JES) classification and inter- and intraobserver agreement of JES intrapapillary capillary loop (IPCL) classification. METHODS:It was a r...

journal_title：Digestion

authors： Mizumoto T,Hiyama T,Quach DT,Sanomura Y,Urabe Y,Oka S,Arihiro K,Tanaka S,Chayama K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Somatostatin and its analogues have antitumor effects on foregut and midgut neuroendocrine (NE) tumors, but their effect on hindgut NE tumors is unclear. We examined the effect of the somatostatin analogue, octreotide, on human rectal NE carcinoma. MATERIALS AND METHODS:Expression of somatostatin receptor (...

journal_title：Digestion

authors： Koizumi M,Onda M,Tanaka N,Seya T,Yamada T,Takahashi Y

更新日期：2002-01-01 00:00:00

abstract：:This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Piastucki I,Radecki T

更新日期：1983-01-01 00:00:00