Abstract:
BACKGROUND:Somatostatin and its analogues have antitumor effects on foregut and midgut neuroendocrine (NE) tumors, but their effect on hindgut NE tumors is unclear. We examined the effect of the somatostatin analogue, octreotide, on human rectal NE carcinoma. MATERIALS AND METHODS:Expression of somatostatin receptor (sst) on NE carcinoma was examined by immunohistochemical staining. Octreotide was added in cell culture medium in order to investigate antiproliferative effect toward NE carcinoma in vitro. Octreotide was administered for 6 weeks to nude mice xenografted with NE carcinoma. We investigated the effect of octreotide on the tumor histologically. The plasma levels of VEGF and bFGF were measured. RESULTS:The NE carcinoma and endothelial cells expressed sst. Octreotide induced NE carcinoma to apoptosis in vitro and in vivo. Octreotide-treated tumors had a massive necrotic area (62.7 +/- 19.3% treated vs. 39.7 +/- 20.34% untreated, p < 0.05). Microvessels in the treated tumor were decreased (264.0 +/- 48.2/mm(2) treated vs. 341.4 +/- 56.6/mm(2) untreated, p < 0.05). The plasma levels of VEGF and bFGF were reduced by octreotide. CONCLUSIONS:Octreotide induces rectal NE carcinoma to apoptosis and inhibits angiogenesis in the tumor. These result in tumor necrosis. Octreotide has an antitumor effect on rectal NE carcinoma.
journal_name
Digestionjournal_title
Digestionauthors
Koizumi M,Onda M,Tanaka N,Seya T,Yamada T,Takahashi Ydoi
10.1159/000063822subject
Has Abstractpub_date
2002-01-01 00:00:00pages
200-6issue
4eissn
0012-2823issn
1421-9867pii
63822journal_volume
65pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND/AIMS:We investigated the effects of indomethacin and rebamipide on the gut microbiota profiles using terminal restriction fragment polymorphism (T-RFLP) analysis. MATERIALS AND METHODS:Female C57BL/6J mice were given indomethacin (10 mg/kg, s.c.) once a day and 2.5 mg rebamipide orally 3 times a day. After ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000341508
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Despite the high prevalence of obstructive sleep apnea syndrome (OSAS), most individuals are unaware of its diagnosis. We assessed whether an upper gastrointestinal (GI) endoscopy can accurately predict the incidence of OSAS. METHODS:After endoscopic evaluation of laryngo-pharyngeal collapse, a total o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000491385
更新日期:2019-01-01 00:00:00
abstract::Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199226
更新日期:1985-01-01 00:00:00
abstract::Differential absorption of D-xylose and 3-O-methyl-D-glucose, and unmediated intestinal permeation of lactulose and L-rhamnose has been investigated in 14 patients with diarrhoea following tropical exposure and in 16 healthy control subjects. Five had malabsorption of fat, D-xylose and B12 ('tropical malabsorption' (T...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199282
更新日期:1986-01-01 00:00:00
abstract::We report on a 39-year-old woman suffering from deep venous thrombosis due to a heterozygous factor-V-Leiden mutation with resistance to activated protein C. Four months after beginning oral anticoagulation, generalized jaundice appeared. Subsequently, subacute liver failure developed necessitating an orthotopic liver...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007710
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND/AIMS:Roux-en-Y gastric bypass surgery is the most common bariatric surgery worldwide. We have described thiamine deficiency in patients with small intestinal bacterial overgrowth after gastric bypass. We hypothesized that symptoms of thiamine deficiency are common after gastric bypass. The aims of this study...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000353245
更新日期:2013-01-01 00:00:00
abstract::Lecithin: cholesterol acyltransferase activity has been measured in serum from patients with various liver disorders and positive LP-X tests and from healthy subjects. Statistical analysis indicated that lecithin: cholesterol acyltransferase activity provided no help in the discrimination between the persons of both g...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198149
更新日期:1978-01-01 00:00:00
abstract::The case of a 52-year-old male with chronic active type B hepatitis in whom severe exacerbation of liver disease was associated with interferon alpha treatment is described. It seems that patients with very active forms of chronic hepatitis B may experience severe and symptomatic exacerbation of liver disease during i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200940
更新日期:1992-01-01 00:00:00
abstract::The basal (interdigestive) gastrointestinal motor activity and the interdigestive gastric acid and pancreatic amylase secretion were determined in 10 young smokers (mean age 23 years) and 7 nonsmokers (mean age 26 years). There was no significant difference in the length of the interdigestive motor complex between smo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199018
更新日期:1984-01-01 00:00:00
abstract::Refractory chronic diarrhea that does not respond to specific antimicrobial therapy or standard unspecific medication may present a challenging and serious clinical problem. Octreotide is a candidate drug for the treatment of these patients as it inhibits gastrointestinal motility, pancreatic secretion and inhibits in...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000051479
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Upper gastrointestinal bleeding (UGB) is an important precipitating factor for the development of hepatic encephalopathy (HE) in cirrhotic patients. The aim of this study was to evaluate the efficacy of lactulose in a controlled randomized trial for prophylaxis of HE after UGB. PATIENTS AND METHODS...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000346083
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Medical therapy of inflammatory bowel disease (IBD) is becoming more complex, given the increasing choice of drugs to treat Crohn's disease (CD) and ulcerative colitis (UC). We aimed to summarize the current guidelines for first-line treatments in IBD. METHODS:An extensive literature search with fo...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000341951
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:It has been demonstrated that cryptogenic pyogenic liver abscess (PLA) is associated with colonic mucosal defect, especially colorectal cancer (CRC). Therefore, the screening of CRC in patients with cryptogenic PLA is important. This study was to investigate whether computed tomographic colonography (CT...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000356534
更新日期:2014-01-01 00:00:00
abstract::The effect of intercurrent diarrhoea on relapse of ulcerative colitis was investigated. Diarrhoea resulting from travel abroad, gastroenteritis or antibiotic usage resulted in an approximately 50% relapse rate. With regard to colonoscopy and barium enema, only the latter was followed by relapse and this may reflect di...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198896
更新日期:1983-01-01 00:00:00
abstract::The effects of two recently developed gastrin receptor antagonists, PD 136450 and L-365,260, on pentagastrin-stimulated acid secretion were investigated in rats. PD 136450 at a dose of 6 mg/kg s.c. (9.6 mumol) completely abolished acid secretion induced by pentagastrin. The inhibition of 18 mg/kg PD 136450 s.c. lasted...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200993
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIMS:Colorectal cancer (CRC) patients are at high risk for developing extracolorectal malignancies (EMs). Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not be...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000449132
更新日期:2016-01-01 00:00:00
abstract::Cell renewal in the duodenal mucosa of Mastomys was studied by autoradiography 1 and 24 h after intraperitoneal injection of tritiated thymidine. Non-specific duodenitis and duodenal ulceration were produced with a continuous infusion of histamine. Mucosal renewal in the duodenum of 30 control Mastomys was compared wi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200226
更新日期:1990-01-01 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine which modifies tissue stromal matrix synthesis, cell proliferation and immune function. In the present study, we have used a mouse monoclonal antibody to the latent (intracytoplasmic) form of TGF-beta 1 to compare its expression in 144 cases ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201249
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:While probiotic bacteria are successfully used in the treatment of ulcerative colitis, the effect of commercially available probiotic products is still controversial. Here, we study whether the number of living probiotic bacteria in yoghurts is altered by an interruption of the cold chain. METHODS:Thre...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000308715
更新日期:2011-01-01 00:00:00
abstract::We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198753
更新日期:1982-01-01 00:00:00
abstract::94 patients with peptic ulcerations of duodenum, stomach, and esophagus, who did not respond to 3 or more months high-dose (450 or 600 mg) treatment with ranitidine, were treated orally with 40 mg omeprazole daily. After healing all patients were offered long-term maintenance therapy with the same dose for 5 years. In...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199610
更新日期:1988-01-01 00:00:00
abstract::Lithium is a cation which has central nervous system effects and is able to interfere with both the release and action of polypeptide hormones. We examined its effect on basal and stimulated plasma gastrin and pancreatic polypeptide (PP) levels in 4 dogs with chronic gastric fistulas. Gastrin and PP release were stimu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198642
更新日期:1981-01-01 00:00:00
abstract::N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200489
更新日期:1990-01-01 00:00:00
abstract::Life events and daily stress were assessed in patients with duodenal ulcer, active or in remission, and in matched disease and normal controls. The mean positive life event scores were significantly lower in duodenal ulcer patients than in disease and healthy controls, and lower in patients with active ulcer than in t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200949
更新日期:1992-01-01 00:00:00
abstract::A highly significant increase in net fluxes across the guinea-pig small intestine for both 45Ca2+ and 35SO4(2-), in the presence of cystic fibrosis plasma compared with non-cystic fibrosis plasma, was observed (p less than 0.001). In the presence of cystic fibrosis plasma, the nuclear, mitochondrial, microsomal and so...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199307
更新日期:1986-01-01 00:00:00
abstract::The aim of the present work was to examine in pigs the effect of a dietary supplementation with the flavor enhancer monosodium glutamate (MSG) on intestinal amino acid metabolism. For this purpose, pigs weighing 60 +/- 2 kg received a standard meal twice a day for 1 week, supplemented with either 10 g MSG per meal or,...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007682
更新日期:1999-07-01 00:00:00
abstract::Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051452
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000288522
更新日期:2011-01-01 00:00:00
abstract::The rates of intracellular transport of newly synthesized amylase, lipase, trypsinogen and chymotrypsinogen were compared in the anaesthesized rat pancreas by measuring their rates of secretion while keeping their relative rates of synthesis in a steady state. It is concluded that pancreatic proteins are not transport...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199327
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007691
更新日期:1999-09-01 00:00:00