Abstract:
:We report on a 39-year-old woman suffering from deep venous thrombosis due to a heterozygous factor-V-Leiden mutation with resistance to activated protein C. Four months after beginning oral anticoagulation, generalized jaundice appeared. Subsequently, subacute liver failure developed necessitating an orthotopic liver transplantation. Histopathology showed features of extensive liver cell necrosis without evidence of a substantial inflammatory infiltrate. Based on histopathology and exclusion of other liver diseases, phenprocoumon-induced liver failure was diagnosed. Five months after transplantation the patient is well with normal liver function tests. Because of the widespread use of oral anticoagulants, not only bleeding complications but also hepatotoxicity should be considered in therapy supervision.
journal_name
Digestionjournal_title
Digestionauthors
Mix H,Wagner S,Böker K,Gloger S,Oldhafer KJ,Behrend M,Flemming P,Manns MPdoi
10.1159/000007710subject
Has Abstractpub_date
1999-11-01 00:00:00pages
579-82issue
6eissn
0012-2823issn
1421-9867pii
7710journal_volume
60pub_type
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