In vivo and in vitro relationship between lipoprotein-X and bile salts in cholestasis.

Abstract:

:Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negative or reduced concentration of LP-X was also studied. There was no relationship, either positive or negative, between serum LP-X and bile acids in 34 patients with cholestasis. Serum was incubated with various saline solutions of taurocholic, lithocholic, deoxycholic and glycocholic acids. The concentration of LP-X decreased only after the final concentrations of bile salts were over 2,000 mumole/1. This is more than five times the concentration of serum bile salts usually found in patients with cholestasis. It is concluded that the negative LP-X test in some patients with cholestases must be explained by some other mechanisms than bile salts.

journal_name

Digestion

journal_title

Digestion

authors

Frisón JC,Ras MR,Rubiés-Prat J,Salvá JA,Masdeu S,Bacardí R

doi

10.1159/000198402

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

411-4

issue

6

eissn

0012-2823

issn

1421-9867

journal_volume

19

pub_type

杂志文章
  • Potential indications for octreotide in gastroenterology: summary of workshop.

    abstract::The potential therapeutic applications of somatostatin and octreotide in gastroenterology involve gut neuro-endocrine tumours, bleeding varices, bleeding peptic ulcers, gastro-intestinal fistulae, pancreatic fistulae, dumping syndrome, pancreatic pseudocysts, short bowel syndrome, acute pancreatitis, AIDS-related diar...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201079

    authors: Burroughs AK,Malagelada R

    更新日期:1993-01-01 00:00:00

  • In search of immunogenic Helicobacter pylori proteins by screening of expression library.

    abstract:BACKGROUND:Prevention of Helicobacter pylori infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no immunization protocol has been accepted for humans. A better characterization of the i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007731

    authors: Lazowska I,Trzeciak L,Godlewska R,Hennig E,Jagusztyn-Krynicka K,Popowski J,Regula J,Ostrowski J

    更新日期:2000-01-01 00:00:00

  • Stimulation of disaccharidase activities in the jejunal brush border membrane of adult rat by total parenteral nutrition. Effects of thyroid hormones.

    abstract::This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the vill...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199030

    authors: Raul F,Galluser M,Doffoel M

    更新日期:1984-01-01 00:00:00

  • Human chorionic gonadotropin-beta in the differentiation of malignancy-related and nonmalignant ascites.

    abstract::The clinical value of the tumor marker human chorionic gonadotropin-beta (hCG-beta) in ascitic fluid for the differentiation of malignancy-related and non-malignant ascites was evaluated. Ascitic fluid protein, cholesterol and cytological examination were determined for comparison. Thirty-six patients with malignancy-...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201324

    authors: Gerbes AL,Hoermann R,Mann K,Jüngst D

    更新日期:1996-01-01 00:00:00

  • Amylase/creatinine clearance ratio and tubular proteinuria in acute pancreatitis.

    abstract::Amylase/creatinine clearance ratio (CAm/CCr), urinary protein concentration and urinary protein pattern were studied in 102 samples from 27 patients with acute pancreatitis and in 46 controls. Raised CAm/CCr, proteinuria and a tubular protein pattern were present in 74, 56 and 96% of the patients, respectively. Howeve...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198397

    authors: Lankisch PG,Wolfrum DI,Koop H,Winckler K

    更新日期:1979-01-01 00:00:00

  • Pancreatic secretory response to sham feeding in humans.

    abstract::We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase p...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198753

    authors: Defilippi C,Solomon TE,Valenzuela JE

    更新日期:1982-01-01 00:00:00

  • Small intestinal edema had the strongest correlation with portal venous pressure amongst capsule endoscopy findings.

    abstract:BACKGROUND/AIM:Previous studies have reported small intestinal lesions in patients with portal hypertensive disease. However, the etiology of these lesions is not clear, as portal venous pressure was not measured in any of these studies. The aim of this study is to clarify the association between small intestinal lesio...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338180

    authors: Takahashi Y,Fujimori S,Narahara Y,Gudis K,Ensaka Y,Kosugi Y,Maki K,Suzuki M,Matsushita Y,Fukuda T,Kanazawa H,Sakamoto C

    更新日期:2012-01-01 00:00:00

  • Clinical profiles, endoscopic and laboratory features and associated factors in patients with autoimmune gastritis.

    abstract:BACKGROUND/AIMS:Autoimmune gastritis (AIG) may predispose to gastric carcinoid tumors or adenocarcinomas and may also cause unexplained iron and/or vitamin B(12) deficiency. The aims of this study were to explore clinical manifestations, endoscopic findings and laboratory features of patients with AIG. METHODS:109 pat...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338295

    authors: Soykan I,Yakut M,Keskin O,Bektaş M

    更新日期:2012-01-01 00:00:00

  • Antiangiogenic effect of octreotide inhibits the growth of human rectal neuroendocrine carcinoma.

    abstract:BACKGROUND:Somatostatin and its analogues have antitumor effects on foregut and midgut neuroendocrine (NE) tumors, but their effect on hindgut NE tumors is unclear. We examined the effect of the somatostatin analogue, octreotide, on human rectal NE carcinoma. MATERIALS AND METHODS:Expression of somatostatin receptor (...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000063822

    authors: Koizumi M,Onda M,Tanaka N,Seya T,Yamada T,Takahashi Y

    更新日期:2002-01-01 00:00:00

  • Impact of histopathology on the outcome of D1/D2 gastrectomies with R0 resection.

    abstract:AIMS:The primary objective of this study was to clarify the influence of histotype on the outcome of D1/D2 gastrectomized patients with pathologically proven R0 resection. The secondary objective was to demonstrate overall survival (OS), disease-free survival (DFS), and locoregional recurrence rates following standard ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338298

    authors: Uslu A,Bati H,Postaci H,Nart A,Eliyatkin N,Yetis H,Corumlu B,Aykas A,Zengel B

    更新日期:2012-01-01 00:00:00

  • What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.

    abstract:BACKGROUND/AIMS:Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000229773

    authors: Shiga H,Takagi S,Inoue R,Kinouchi Y,Ohkubo T,Takahashi S,Negoro K,Yokoyama H,Kato S,Fukushima K,Hiwatashi N,Shimosegawa T

    更新日期:2010-01-01 00:00:00

  • Effects of dexamethasone and linoleic acid on hepatic secretion of biliary lipids and anionic polypeptide factor: In vivo and in vitro studies.

    abstract::Synthetic glucocorticoids, such as dexamethasone, and diets enriched with unsaturated fatty acids have been shown to stimulate hepatic bile salt synthesis. This fact led us to investigate the effects of dexamethasone and linoleic acid supplementation on bile secretion. Cholesterol (Ch) and phospholipid secretions are ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007700

    authors: Domingo N,Debono E,Reynier MO,Crotte C,Thorin B,Charbonnier M,Clerc T,Grillasca J,Chanussot F,Lafont H

    更新日期:1999-11-01 00:00:00

  • Survival Impact of Extracolorectal Malignancies in Colorectal Cancer Patients.

    abstract:BACKGROUND/AIMS:Colorectal cancer (CRC) patients are at high risk for developing extracolorectal malignancies (EMs). Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not be...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000449132

    authors: Kawai K,Ishihara S,Nozawa H,Hata K,Kiyomatsu T,Tanaka T,Nishikawa T,Otani K,Yasuda K,Murono K,Sasaki K,Watanabe T

    更新日期:2016-01-01 00:00:00

  • Characterization of the gastroprotective effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine hydrochloride, a non-H1/non-H2 histamine antagonist.

    abstract::N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200489

    authors: Glavin GB,Gerrard JM

    更新日期:1990-01-01 00:00:00

  • Effects of the soluble fibre pectin on intestinal cell proliferation, fecal short chain fatty acid production and microbial population.

    abstract:AIM:Although pectin, a dietary fibre, has been suggested to possess some trophic effects on the intestine, the mechanisms involved remain unclear. This study aimed to evaluate the effects of pectin on rat intestinal cell proliferation and the intraluminal environment. METHODS:Control and pectin-fed rats were given a f...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000069705

    authors: Fukunaga T,Sasaki M,Araki Y,Okamoto T,Yasuoka T,Tsujikawa T,Fujiyama Y,Bamba T

    更新日期:2003-01-01 00:00:00

  • The pepsinogens of cat gastric mucosa and the pepsins derived from them.

    abstract::Fundic mucosal extracts of the cat were examined by chromatography using DEAE-cellulose at pH 5.3. The peaks of proteolytic activity located by this method were shown to be heterogeneous on electrophoresis. By electrophoresis of individual homogenous chromatographic fractions 9 separate zones of proteolytic activity w...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197919

    authors: Shaw B,Wright CL

    更新日期:1976-01-01 00:00:00

  • Effect of fasting and refeeding on basolateral polyamine uptake and metabolism by the rat small bowel.

    abstract::Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200737

    authors: Bardócz S,Grant G,Brown DS,Ewen SW,Stewart JC,Pusztai A

    更新日期:1991-01-01 00:00:00

  • Apparent post-transcriptional modification of ornithine decarboxylase accounts for its induction in IEC-6 cells in culture.

    abstract::Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200412

    authors: Seidel ER,Ginty DD

    更新日期:1990-01-01 00:00:00

  • Pain in the Early Phase of Pediatric Pancreatitis (PINEAPPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial.

    abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000441352

    authors: Zsoldos F,Párniczky A,Mosztbacher D,Tóth A,Lásztity N,Hegyi P,Hungarian Pancreatic Study Group and the International Association of Pancreatology.

    更新日期:2016-01-01 00:00:00

  • Defective inhibition of gastrin release by antral distension in duodenal ulcer patients.

    abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200869

    authors: Sjövall M,Lindstedt G,Olbe L,Lundell L

    更新日期:1992-01-01 00:00:00

  • Changes in urinary nitrate and nitrite during treatment of ulcerative colitis.

    abstract::The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. During the active phase of the disease, the NO3 excretion was significantly higher in the patients than in healthy controls (n = 6, p < 0....

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201332

    authors: Sasajima K,Yoshida Y,Yamakado S,Sato J,Miyashita M,Okawa K,Matsutani T,Onda M,Kawano E

    更新日期:1996-01-01 00:00:00

  • Salivary secretion in chronic pancreatitis with special reference to albumin and lactoferrin.

    abstract::Saliva from one parotid gland was collected under citric acid stimulation in three groups consisting of 69 control subjects and two groups consisting of 25 patients with chronic and relapsing chronic pancreatitis. Mixed saliva was collected under mechanical stimulation from 10 patients and 6 control subjects. Flow rat...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198781

    authors: Dürr GH,Amouric M,Bode C,Bode JC,Sarles H,Figarella C

    更新日期:1982-01-01 00:00:00

  • Multimicrobial sepsis including Clostridium perfringens after chemoembolization of a single liver metastasis from common bile duct cancer.

    abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007815

    authors: Eckel F,Lersch C,Huber W,Weiss W,Berger H,Schulte-Frohlinde E

    更新日期:2000-01-01 00:00:00

  • Conscious Sedation Using Midazolam and Sequential Flumazenil in Cirrhotic Patients for Prophylactic Endoscopic Variceal Ligation.

    abstract:BACKGROUND/AIMS:This study investigated the safety of endoscopic variceal ligation (EVL) under conscious sedation with midazolam and sequential flumazenil after procedure in these patients. METHODS:A total of 279 patients who underwent secondary prophylactic EVL at our institution between April 2012 and June 2014, wer...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000440715

    authors: Kim SI,Jin YJ,Lee SH,Lee JW,Lee DH,Lee D

    更新日期:2015-01-01 00:00:00

  • Evaluation of the 75Se-l-selenomethionine test for pancreatic disease. Studies on gel filtration.

    abstract::Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198444

    authors: Pointner H,Kletter K

    更新日期:1980-01-01 00:00:00

  • A rapid method of relating protein to flow in human pancreatic secretions.

    abstract::A method of obtaining linear plots of protein-flow data from human pancreatic ductal secretions is described. The protein concentration in pancreatic secretions, when related to flow rates in two individuals, gave similar regression lines, with the correlation coefficients or r = -0.97 and -0.98, respectively, and slo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197922

    authors: Allan BJ,White TT

    更新日期:1976-01-01 00:00:00

  • Ratio of urinary 6beta-hydroxycortisol to 17-hydroxycorticosteroids in patients with liver disease.

    abstract::The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198068

    authors: Eade OE,Maddison A,Leonard PJ,Wright R

    更新日期:1977-01-01 00:00:00

  • Efficacy of Upper Gastrointestinal Endoscopic Examination to Identify Patients with Obstructive Sleep Apnea Syndrome: A Retrospective Cross-Sectional Study.

    abstract:BACKGROUND/AIMS:Despite the high prevalence of obstructive sleep apnea syndrome (OSAS), most individuals are unaware of its diagnosis. We assessed whether an upper gastrointestinal (GI) endoscopy can accurately predict the incidence of OSAS. METHODS:After endoscopic evaluation of laryngo-pharyngeal collapse, a total o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000491385

    authors: Ohata K,Sakai E,Nakao T,Kimoto Y,Ishii R,Konishi T,Ueno S,Takita M,Negishi R,Morinushi T,Muramoto T,Matsuhashi N,Nakaya T,Koba I,Nakaji S

    更新日期:2019-01-01 00:00:00

  • Existence of variant gamma delta T cells in Crohn's disease.

    abstract:BACKGROUND AND OBJECTIVES:gamma delta T cell populations are well-known for their unique distribution (e.g. intra-epithelial lymphocytes). Though their ligands play a major role in the immune response they have remained largely obscure. To shed light on this issue, we have analyzed in this study the complementarity det...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051911

    authors: Ishiguro Y,Kanazawa H,Yamagata K,Sakuraba H,Munakata A

    更新日期:2001-01-01 00:00:00

  • Self-Completion Method of Endoscopic Submucosal Dissection Using Endosaber without Any Other Device or Assistance: An ex vivo Porcine Model Study.

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed a self-completion method of ESD using Endosaber to eliminate the need for an additional device or human assistance during the procedure. The aim of this study was to evaluate the technical fe...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000502771

    authors: Esaki M,Minoda Y,Wada M,Sakisaka S,Tsuruta S,Hosokawa T,Matsuguchi T,Ichijima R,Suzuki S,Tamura Y,Iwao A,Yamakawa S,Irie A,Ihara E,Ogawa Y

    更新日期:2019-09-27 00:00:00