Abstract:
:Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negative or reduced concentration of LP-X was also studied. There was no relationship, either positive or negative, between serum LP-X and bile acids in 34 patients with cholestasis. Serum was incubated with various saline solutions of taurocholic, lithocholic, deoxycholic and glycocholic acids. The concentration of LP-X decreased only after the final concentrations of bile salts were over 2,000 mumole/1. This is more than five times the concentration of serum bile salts usually found in patients with cholestasis. It is concluded that the negative LP-X test in some patients with cholestases must be explained by some other mechanisms than bile salts.
journal_name
Digestionjournal_title
Digestionauthors
Frisón JC,Ras MR,Rubiés-Prat J,Salvá JA,Masdeu S,Bacardí Rdoi
10.1159/000198402subject
Has Abstractpub_date
1979-01-01 00:00:00pages
411-4issue
6eissn
0012-2823issn
1421-9867journal_volume
19pub_type
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