Ratio of urinary 6beta-hydroxycortisol to 17-hydroxycorticosteroids in patients with liver disease.

Abstract:

:The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients with acute hepatitis. We feel that the use of the ratio as a test of early liver cell dysfunction requires further evaluation, in particular in the early recognition of metastatic liver disease.

journal_name

Digestion

journal_title

Digestion

authors

Eade OE,Maddison A,Leonard PJ,Wright R

doi

10.1159/000198068

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

169-74

issue

1-2

eissn

0012-2823

issn

1421-9867

journal_volume

16

pub_type

杂志文章
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    pub_type: 杂志文章

    doi:10.1159/000198408

    authors: Urban E,Ricks PM

    更新日期:1980-01-01 00:00:00

  • Argyrophil cell hyperplasia of fundic mucosa in patients with chronic atrophic gastritis.

    abstract::Eighteen cases of severe hyperplasia of fundic argyrophil cells observed during routine histologic examination of endoscopic gastric biopsy specimens from unselected patients with upper gastro-intestinal symptomatology were investigated. All patients, except one, were female with a mean age of 57 years. Atrophic gastr...

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    pub_type: 杂志文章

    doi:10.1159/000199389

    authors: Bordi C,Pilato F,Carfagna G,Ferrari C,D'Adda T,Sivelli R,Bertelé A,Missale G

    更新日期:1986-01-01 00:00:00

  • Esophageal Cancer: New Insights into a Heterogenous Disease.

    abstract:BACKGROUND:Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. ...

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    pub_type: 杂志文章

    doi:10.1159/000464130

    authors: Krug S,Michl P

    更新日期:2017-01-01 00:00:00

  • The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000112646

    authors: Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

    更新日期:2007-01-01 00:00:00

  • Questionnaire-based survey conducted in 2011 concerning endoscopic management of Barrett's esophagus in East Asian countries.

    abstract:BACKGROUND/AIMS:Endoscopic definitions and management of Barrett's esophagus vary widely among countries. To examine the current situation regarding diagnosis, epidemiology, management and treatment of Barrett's esophagus in East Asian countries using a questionnaire-based survey. METHODS:Representative members of the...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000339778

    authors: Ishimura N,Amano Y,Sollano JD,Zhu Q,Kachintorn U,Rani AA,Hahm KB,Takahashi S,Arakawa T,Joh T,Matsumoto T,Naito Y,Suzuki H,Ueno F,Fukudo S,Fujiwara Y,Kamiya T,Uchiyama K,Kinoshita Y,IGICS Study Group.

    更新日期:2012-01-01 00:00:00

  • Human pancreas-specific protein/procarboxypeptidase B: a useful serum marker of acute pancreatitis.

    abstract::The aim of this study was to evaluate the serum behavior of human pancreas-specific protein/procarboxypeptidase B (hPASP/PCPB) in the early phases of acute pancreatitis, and to calculate its sensitivity and specificity in comparison with those of serum amylase and lipase in the diagnosis of this illness. Twenty-six ac...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201128

    authors: Pezzilli R,Billi P,Platè L,Bongiovanni F,Morselli Labate AM,Miglioli M

    更新日期:1994-01-01 00:00:00

  • Accumulation of 8-hydroxy-2'-deoxyguanosine adducts in HBx recombinant HepG2 cells and HBx transgenic mice.

    abstract:BACKGROUND/AIMS:Transgenic mice overexpressing hepatitis B x protein (HBx) show an increased susceptibility to mutations if exposed to mutagens. Also involved in HBx signalling, reactive oxygen intermediates (ROI) can induce DNA adducts such as 8-hydroxy-2'-deoxyguanosine that can in turn lead to G/T transversion mutat...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000080930

    authors: Gehrke R,Brauchle MA,Reifenberg K,Hildt E,Gruetzner U,Schmitz V,Schlicht HJ,Hofschneider PH,Caselmann WH,Rabe C

    更新日期:2004-01-01 00:00:00

  • Modulation of human gastric mucosal adenylate cyclase activity by prostacyclin.

    abstract::Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 m...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198335

    authors: Simon B,Kather H

    更新日期:1979-01-01 00:00:00

  • Constipation in patients with thiamine deficiency after Roux-en-Y gastric bypass surgery.

    abstract:BACKGROUND/AIMS:Roux-en-Y gastric bypass surgery is the most common bariatric surgery worldwide. We have described thiamine deficiency in patients with small intestinal bacterial overgrowth after gastric bypass. We hypothesized that symptoms of thiamine deficiency are common after gastric bypass. The aims of this study...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000353245

    authors: Shah HN,Bal BS,Finelli FC,Koch TR

    更新日期:2013-01-01 00:00:00

  • In search of immunogenic Helicobacter pylori proteins by screening of expression library.

    abstract:BACKGROUND:Prevention of Helicobacter pylori infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no immunization protocol has been accepted for humans. A better characterization of the i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007731

    authors: Lazowska I,Trzeciak L,Godlewska R,Hennig E,Jagusztyn-Krynicka K,Popowski J,Regula J,Ostrowski J

    更新日期:2000-01-01 00:00:00

  • Defective inhibition of gastrin release by antral distension in duodenal ulcer patients.

    abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200869

    authors: Sjövall M,Lindstedt G,Olbe L,Lundell L

    更新日期:1992-01-01 00:00:00

  • The role of catecholamines in the control of gastrin and acid secretion during insulin hypoglycaemia in man.

    abstract::5 adrenalectomized subjects and 8 healthy volunteers underwent an insulin test during which acid secretion and plasma adrenaline, noradrenaline, dopamine and gastrin concentrations were measured. Plasma glucose concentration fell by greater than 50% in all subjects. The mean plasma adrenaline concentration increased m...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198547

    authors: Järhult J,Hamberger B,Lanthén G,Ors M,Uvnäs-Wallensten K

    更新日期:1981-01-01 00:00:00

  • The effect of L-amino acids given intravenously on gastric secretion stimulated by pentagastrin in dogs.

    abstract::L-Amino acid solution given intravenously in Heidenhain pouch dogs resulted in marked changes of both basal and pentagastrin-stimulated gastric secretions. During a 1-hour amino acid infusion, a significant augmentation of pentagastrin-induced secretion was observed. A significant increase of secretion during amino ac...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198207

    authors: Bilski R,Kowalewski K,Secord DC

    更新日期:1978-01-01 00:00:00

  • Gastrin and gastric enterochromaffin-like cell carcinoids in the rat.

    abstract::Life-long administration (greater than or equal to 2 years) of a number of long-acting gastric acid inhibitors (including H2-receptor antagonists, omeprazole and ciprofibrate) has been associated with the development of gastric enterochromaffin-like cell (ECL cell) carcinoids in rats. It has been postulated that they ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200510

    authors: Carlsson E,Havu N,Mattsson H,Ekman L

    更新日期:1990-01-01 00:00:00

  • Optimizing symptom relief and preventing complications in adults with gastro-oesophageal reflux disease.

    abstract::Gastro-oesophageal reflux disease (GORD) is a chronic illness causing recurrent typical and atypical symptoms. Possible complications include oesophagitis, ulcer, stricture and Barrett's oesophagus. Evidence suggests that the intraoesophageal pH correlates directly with the degree of mucosal injury. Proton pump inhibi...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000076371

    authors: Savarino V,Dulbecco P

    更新日期:2004-01-01 00:00:00

  • A Novel Noninvasive Method for Quantitative Detection of Colonic Dysmotility Using Real-Time Ultrasonography.

    abstract:INTRODUCTION:Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. OBJECTIVES:The aim of this study was to establish a novel quantitative meth...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000511851

    authors: Kishi K,Kaji N,Tsuru Y,Hori M

    更新日期:2020-12-01 00:00:00

  • Healing of grade-II and III oesophagitis through motility stimulation with cisapride.

    abstract::The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000200231

    authors: Lepoutre L,Van der Spek P,Vanderlinden I,Bollen J,Laukens P

    更新日期:1990-01-01 00:00:00

  • The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study.

    abstract:BACKGROUND/AIMS:Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected in...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000479000

    authors: Ohtsu T,Takagi A,Uemura N,Inoue K,Sekino H,Kawashima A,Uchida M,Koga Y

    更新日期:2017-01-01 00:00:00

  • Capnographic monitoring during endoscopic submucosal dissection with patients under deep sedation: a prospective, crossover trial of air and carbon dioxide insufflations.

    abstract:BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000328694

    authors: Takano A,Kobayashi M,Takeuchi M,Hashimoto S,Mizuno K,Narisawa R,Aoyagi Y

    更新日期:2011-01-01 00:00:00

  • Double-Filtration Plasmapheresis plus Interferon-β for HCV-1b Patients with Non-Sustained Virological Response to Previous Combination Therapy.

    abstract:BACKGROUND AND AIMS:Double-filtration plasmapheresis (DFPP) together with interferon (IFN) administration produces a substantial reduction in the viral load during the early stages of treatment. METHODS:Based on their responses to previous pegylated IFN and ribavirin (PEG-IFN/RBV) therapy, 20 patients were divided int...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000333209

    authors: Kim SR,Saito J,Imoto S,Komaki T,Nagata Y,Kim KI,Sasase N,Kimura N,Sasatani K,Konishi E,Hasegawa Y,Fujinami A,Ohta M,El-Shamy A,Tanaka Y,Sugano M,Sakashita M,Nakamura A,Tsuchida S,Makino T,Kawada T,Nakajima T,M

    更新日期:2011-01-01 00:00:00

  • Validity of a novel biopsy urease test (HUT) and a simplified 13C-urea breath test for diagnosis of Helicobacter pylori infection and estimation of the severity of gastritis.

    abstract::This prospective study was designed to validate a novel biopsy urease test as well as a simplified 13C-urea breath test for the detection of Helicobacter pylori. In addition, the hypothesis was tested that both the reaction velocity of the urease test and the 13CO2 excess of the urea breath test may allow a prediction...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201366

    authors: Labenz J,Bärsch G,Peitz U,Aygen S,Hennemann O,Tillenburg B,Becker T,Stolte M

    更新日期:1996-11-01 00:00:00

  • Effect of cystic fibrosis and non-cystic fibrosis plasma on 45Ca and 35SO4 uptake and retention by the small intestine at the cellular level in the guinea pig.

    abstract::A highly significant increase in net fluxes across the guinea-pig small intestine for both 45Ca2+ and 35SO4(2-), in the presence of cystic fibrosis plasma compared with non-cystic fibrosis plasma, was observed (p less than 0.001). In the presence of cystic fibrosis plasma, the nuclear, mitochondrial, microsomal and so...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199307

    authors: Morrissey SM,Mehta JG

    更新日期:1986-01-01 00:00:00

  • Investigation of genome instability in exfoliated colonic epithelial cells and in mitogen-stimulated lymphocytes of patients with ulcerative colitis.

    abstract:OBJECTIVE:The present study aimed to evaluate the micronucleus (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in the mitogen-stimulated lymphocytes of patients with ulcerative colitis (UC). In addition, we assessed MN frequency in exfoliated colonic epithelial cells obtained from both the diseased and heal...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000336358

    authors: Karaman A,Hamurcu Z,Donmez H,Bitken N,Karaman H,Baskol M,Gursoy S,Guven K,Ozbakir O,Yucesoy M

    更新日期:2012-01-01 00:00:00

  • Correlation of gut hormones with irritable bowel syndrome.

    abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a functional bowel disorder which is characterized by abdominal pain and disturbed bowel habits. The pathophysiological mechanism is complex and still remains incompletely clear. Alterations at both the central and the peripheral level are thought to contribute to the sympto...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000165352

    authors: Zhang H,Yan Y,Shi R,Lin Z,Wang M,Lin L

    更新日期:2008-01-01 00:00:00

  • Multimicrobial sepsis including Clostridium perfringens after chemoembolization of a single liver metastasis from common bile duct cancer.

    abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007815

    authors: Eckel F,Lersch C,Huber W,Weiss W,Berger H,Schulte-Frohlinde E

    更新日期:2000-01-01 00:00:00

  • Factors regulating prostaglandin uptake by rat small intestine.

    abstract::The uptake of prostaglandin E1 by rat intestine mucosal strips was investigated. The results indicate that: (1) PGE1 did not accumulate in the epithelial cells of rat intestine. The intracellular to extracellular distribution ratio did not reach unity in spite of the extended periods of incubation. (2) A decrease in t...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198774

    authors: Nassar CF,Haddad ME,Khuri RN

    更新日期:1982-01-01 00:00:00

  • Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related chronic gastritis.

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    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000321799

    authors: Okubo M,Tahara T,Shibata T,Nakamura M,Kamiya Y,Yoshioka D,Maeda Y,Yonemura J,Ishizuka T,Arisawa T,Hirata I

    更新日期:2011-01-01 00:00:00

  • True adenomas of the cardia: a case series of 3 patients.

    abstract:BACKGROUND/AIM:True adenomas of the cardia appear to be extremely rare lesions. There are no data on the natural history and histopathological background of these lesions. We report 3 patients with true adenomas of the cardia. METHODS AND RESULTS:Three patients with polypoid masses at the cardia below the Z-line were ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000121413

    authors: Bajbouj M,von Weyhern C,Becker V,Seidl S,Ott R,Schatke W,Fend F,Schmid RM,Meining A

    更新日期:2008-01-01 00:00:00

  • Omeprazole in the short-term treatment of reflux oesophagitis.

    abstract::Studies with short-term administration of omeprazole in patients with erosive or ulcerative reflux oesophagitis have demonstrated that strong inhibition of gastric acid secretion will become the therapy of choice for these patients. However, because reflux oesophagitis relapses rapidly when short-term treatment is dis...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200103

    authors: Jansen JB,Lamers CB

    更新日期:1989-01-01 00:00:00

  • Protective effect of lactoferrin on caerulein-induced acute pancreatitis in rats.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201018

    authors: Koike D,Makino I

    更新日期:1993-01-01 00:00:00