Abstract:
BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status. To clarify the clinical safety of CO(2) insufflation, we conducted a crossover trial of air and CO(2) insufflations. METHODS:A total of 60 patients with early esophageal or gastric cancers underwent ESD during which insufflation was switched from CO(2) to air or from air to CO(2); transcutaneous partial pressure CO(2) (PtcCO(2)) was monitored in all patients. We also assessed respiratory function, arterial blood gas analysis, and smoking history. RESULTS:Although significant increases in PtcCO(2) from baseline were observed, there were no significant differences in PtcCO(2) levels during CO(2) insufflation compared with levels during air insufflation in groups that received CO(2) preceding air or air preceding CO(2). All patients underwent ESD safely without adverse events, including 20 patients with subclinical respiratory dysfunction. The sedation protocol was the only significant predictor of CO(2) retention, independent of CO(2) insufflation. CONCLUSIONS:CO(2) insufflation can be used as safely as air insufflation during ESD under deep sedation.
journal_name
Digestionjournal_title
Digestionauthors
Takano A,Kobayashi M,Takeuchi M,Hashimoto S,Mizuno K,Narisawa R,Aoyagi Ydoi
10.1159/000328694subject
Has Abstractpub_date
2011-01-01 00:00:00pages
193-8issue
3eissn
0012-2823issn
1421-9867pii
000328694journal_volume
84pub_type
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