Capnographic monitoring during endoscopic submucosal dissection with patients under deep sedation: a prospective, crossover trial of air and carbon dioxide insufflations.

Abstract:

BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status. To clarify the clinical safety of CO(2) insufflation, we conducted a crossover trial of air and CO(2) insufflations. METHODS:A total of 60 patients with early esophageal or gastric cancers underwent ESD during which insufflation was switched from CO(2) to air or from air to CO(2); transcutaneous partial pressure CO(2) (PtcCO(2)) was monitored in all patients. We also assessed respiratory function, arterial blood gas analysis, and smoking history. RESULTS:Although significant increases in PtcCO(2) from baseline were observed, there were no significant differences in PtcCO(2) levels during CO(2) insufflation compared with levels during air insufflation in groups that received CO(2) preceding air or air preceding CO(2). All patients underwent ESD safely without adverse events, including 20 patients with subclinical respiratory dysfunction. The sedation protocol was the only significant predictor of CO(2) retention, independent of CO(2) insufflation. CONCLUSIONS:CO(2) insufflation can be used as safely as air insufflation during ESD under deep sedation.

journal_name

Digestion

journal_title

Digestion

authors

Takano A,Kobayashi M,Takeuchi M,Hashimoto S,Mizuno K,Narisawa R,Aoyagi Y

doi

10.1159/000328694

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

193-8

issue

3

eissn

0012-2823

issn

1421-9867

pii

000328694

journal_volume

84

pub_type

杂志文章,随机对照试验
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    authors: Layer P,Hotz J,Goebell H

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    doi:10.1159/000199360

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    doi:10.1159/000500907

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    doi:10.1159/000199731

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    更新日期:1988-01-01 00:00:00

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198408

    authors: Urban E,Ricks PM

    更新日期:1980-01-01 00:00:00

  • Polyamine uptake across the basolateral membrane of the enterocyte is mediated by a high-affinity carrier: a study using isolated basolateral membrane vesicles.

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    authors: Milovic V,Caspary WF,Stein J

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1980-01-01 00:00:00

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

    doi:10.1159/000333209

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    pub_type: 杂志文章

    doi:10.1159/000200993

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    更新日期:1992-01-01 00:00:00

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