Abstract:
:The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four times a day (n = 11) or placebo (n = 8). Cisapride was superior to placebo with regard to mucosal healing (p less than 0.001) and symptomatic improvement (p less than 0.05): at the end of treatment, healing (grade 0) was observed in 8 cisapride patients, against 1 placebo patient, and reflux symptoms had disappeared in 7 and 1 patients, respectively. In conclusion, cisapride was of significant benefit to oesophagitis patients and was well tolerated.
journal_name
Digestionjournal_title
Digestionauthors
Lepoutre L,Van der Spek P,Vanderlinden I,Bollen J,Laukens Pdoi
10.1159/000200231subject
Has Abstractpub_date
1990-01-01 00:00:00pages
109-14issue
2eissn
0012-2823issn
1421-9867journal_volume
45pub_type
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