Healing of grade-II and III oesophagitis through motility stimulation with cisapride.

Abstract:

:The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four times a day (n = 11) or placebo (n = 8). Cisapride was superior to placebo with regard to mucosal healing (p less than 0.001) and symptomatic improvement (p less than 0.05): at the end of treatment, healing (grade 0) was observed in 8 cisapride patients, against 1 placebo patient, and reflux symptoms had disappeared in 7 and 1 patients, respectively. In conclusion, cisapride was of significant benefit to oesophagitis patients and was well tolerated.

journal_name

Digestion

journal_title

Digestion

authors

Lepoutre L,Van der Spek P,Vanderlinden I,Bollen J,Laukens P

doi

10.1159/000200231

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

109-14

issue

2

eissn

0012-2823

issn

1421-9867

journal_volume

45

pub_type

临床试验,杂志文章,随机对照试验
  • Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms.

    abstract:INTRODUCTION:We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated w...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000511589

    authors: Esaki M,Yamamura T,Nakamura M,Maeda K,Sawada T,Mizutani Y,Ishikawa E,Suzuki H,Kuno T,Yamada K,Hasegawa I,Ishikawa T,Kakushima N,Furukawa K,Ohno E,Kawashima H,Hirooka Y,Fujishiro M

    更新日期:2020-11-18 00:00:00

  • Metabolic Alterations in Celiac Disease Occurring after Following a Gluten-Free Diet.

    abstract:BACKGROUND AND AIM:Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000495749

    authors: Ciccone A,Gabrieli D,Cardinale R,Di Ruscio M,Vernia F,Stefanelli G,Necozione S,Melideo D,Viscido A,Frieri G,Latella G

    更新日期:2019-01-01 00:00:00

  • Comparison of bile salt perturbation of duodenal and jejunal isolated brush-border membranes.

    abstract::Rabbit duodenal and jejunal brush-border membrane vesicle integrity, fluidity and passive proton permeability were studied after in vitro exposure to deoxycholate, glycodeoxycholate or taurodeoxycholate. Duodenal and jejunal membrane mean vesicle volume [0.54 (0.05) and 0.54 (0.03) microliters/mg, mean values with SE ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200498

    authors: Zhao DL,Hirst BH

    更新日期:1990-01-01 00:00:00

  • Effect of filtrate containing Clostridium difficile toxin on rectal mucosa maintained in organ culture.

    abstract::Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199212

    authors: Allan A,Jewell DP

    更新日期:1985-01-01 00:00:00

  • Implication of cholecystokinin in pancreatic adaptation after biliopancreatic bypass in the rat.

    abstract::Biliopancreatic bypass (BPB), a bariatric surgical procedure, leads to a malnutrition-induced general visceral atrophy except for the pancreas. This work investigates the implication of cholecystokinin (CCK) in the exocrine pancreatic adaptive process using a plasma CCK assay and the CCK receptor antagonist CR 1409. N...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201149

    authors: Evrard S,Hoeltzel A,Aprahamian M,Bernard C,Mutter D,Marescaux J,Damgé C

    更新日期:1994-01-01 00:00:00

  • Role of the ileocecal valve and site of intestinal resection in malabsorption after extensive small bowel resection.

    abstract::Intestinal absorption after extensive small bowel resections, for diseases other than Crohn's disease, was studied in 17 patients. When the ileocecal valve and the right colon were preserved, malabsorption was transient and moderate and had no prejudicial nutritional effect (fecal fat: 8.8 +/- 1.8 g/24 h in resections...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198220

    authors: Cosnes J,Gendre JP,Le Quintrec Y

    更新日期:1978-01-01 00:00:00

  • Therapy with omeprazole in patients with peptic ulcerations resistant to extended high-dose ranitidine treatment.

    abstract::94 patients with peptic ulcerations of duodenum, stomach, and esophagus, who did not respond to 3 or more months high-dose (450 or 600 mg) treatment with ranitidine, were treated orally with 40 mg omeprazole daily. After healing all patients were offered long-term maintenance therapy with the same dose for 5 years. In...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199610

    authors: Brunner G,Creutzfeldt W,Harke U,Lamberts R

    更新日期:1988-01-01 00:00:00

  • What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.

    abstract:BACKGROUND/AIMS:Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000229773

    authors: Shiga H,Takagi S,Inoue R,Kinouchi Y,Ohkubo T,Takahashi S,Negoro K,Yokoyama H,Kato S,Fukushima K,Hiwatashi N,Shimosegawa T

    更新日期:2010-01-01 00:00:00

  • Gene expression profiles on hypoxia and reoxygenation in rat gastric epithelial cells: a high-density DNA microarray analysis.

    abstract::Previous investigations have demonstrated that the cellular signaling induced by hypoxia-reoxygenation is a major pathway contributing to gastric mucosal injury induced by stress, non-steroidal anti-inflammatory drugs, and Helicobacter pylori. The aim of the present study was to perform a gene expression analysis of t...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000094039

    authors: Katada K,Naito Y,Mizushima K,Takagi T,Handa O,Kokura S,Ichikawa H,Yoshida N,Matsui H,Yoshikawa T

    更新日期:2006-01-01 00:00:00

  • Acute pancreatitis in the Guangdong Province, China.

    abstract:BACKGROUND/AIMS:Many studies have recently been published on acute pancreatitis; however, few large-sample studies have been focused on the risk factors for deaths in severe acute pancreatitis. To address this issue, the present study was intended to assess etiology, severity, and mortality of acute pancreatitis in the...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000102959

    authors: Bai Y,Jia L,Wang B,Yang B,Wang L,Shi X,Zhang W,Liu Y,Zou D,Li Z

    更新日期:2007-01-01 00:00:00

  • Somatostatin receptor imaging: predictive and prognostic considerations.

    abstract::Compared with other imaging modalities and clinical investigation, the 111In-pentetreotide scan identified additional metastatic disease sites in 12 carcinoid patients and 2 occult primaries, and influenced the therapeutic outcome in 36 patients [29 carcinoids, 2 atypical carcinoids, 3 cancers of unknown primaries (CU...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201396

    authors: Anthony LB,Martin W,Delbeke D,Sandler M

    更新日期:1996-01-01 00:00:00

  • Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis.

    abstract:BACKGROUND/AIMS:Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS. METHODS:IBS patients of the diarr...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000333083

    authors: Gecse K,Róka R,Séra T,Rosztóczy A,Annaházi A,Izbéki F,Nagy F,Molnár T,Szepes Z,Pávics L,Bueno L,Wittmann T

    更新日期:2012-01-01 00:00:00

  • Patency Capsule Tolerability in School-Aged Children.

    abstract:BACKGROUND:A patency capsule (PC) can help predict capsule endoscope (CE) retention; however, PC tolerability is unknown in children. We retrospectively evaluated PC tolerability in school-aged children. METHODS:Sixty-one patients (median age, 12.9 years; range 7.4-17.3 years) who underwent PC examination were analyze...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000477579

    authors: Tokuhara D,Watanabe K,Cho Y,Shintaku H

    更新日期:2017-01-01 00:00:00

  • Central leptin and cholecystokinin in gastroprotection against ethanol-induced damage.

    abstract:BACKGROUND:Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal in...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007805

    authors: Brzozowski T,Konturek PC,Konturek SJ,Pierzchalski P,Bielanski W,Pajdo R,Drozdowicz D,Kwiecień S,Hahn EG

    更新日期:2000-01-01 00:00:00

  • Therapy of viral hepatitis.

    abstract::Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000007532

    authors: Hoofnagle JH

    更新日期:1998-08-01 00:00:00

  • Short bowel syndrome.

    abstract::Nine patients with short bowel syndrome and high intestinal output received octreotide either intravenously (50-100 micrograms t.i.d.) or subcutaneously (100 micrograms b.i.d.) on 2 test days. In the 6 patients with net secretory output, there was a reduction in mean daily intestinal output of 0.5-5.0 kg; total daily ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200267

    authors: Nightingale JM,Walker ER,Burnham WR,Farthing MJ,Lennard-Jones JE

    更新日期:1990-01-01 00:00:00

  • Efficacy of Upper Gastrointestinal Endoscopic Examination to Identify Patients with Obstructive Sleep Apnea Syndrome: A Retrospective Cross-Sectional Study.

    abstract:BACKGROUND/AIMS:Despite the high prevalence of obstructive sleep apnea syndrome (OSAS), most individuals are unaware of its diagnosis. We assessed whether an upper gastrointestinal (GI) endoscopy can accurately predict the incidence of OSAS. METHODS:After endoscopic evaluation of laryngo-pharyngeal collapse, a total o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000491385

    authors: Ohata K,Sakai E,Nakao T,Kimoto Y,Ishii R,Konishi T,Ueno S,Takita M,Negishi R,Morinushi T,Muramoto T,Matsuhashi N,Nakaya T,Koba I,Nakaji S

    更新日期:2019-01-01 00:00:00

  • Clinical, controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract.

    abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199876

    authors: Coraggio F,Bertini G,Catalano A,Scarpato P,Gualdieri L

    更新日期:1989-01-01 00:00:00

  • Long-term outcome after double-balloon endoscopy in patients with obscure gastrointestinal bleeding.

    abstract:BACKGROUND AND AIMS:There are limited data concerning the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) after double-balloon endoscopy (DBE). The aim of the present study was to evaluate the long-term outcome of patients with OGIB after DBE. PATIENTS AND METHODS:Eighty-seven consecutive pa...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000313360

    authors: Fujita M,Manabe N,Honda K,Tarumi K,Murao T,Katada S,Kimura Y,Matsumoto H,Kamada T,Shiotani A,Hata J,Haruma K

    更新日期:2010-01-01 00:00:00

  • Ratio of urinary 6beta-hydroxycortisol to 17-hydroxycorticosteroids in patients with liver disease.

    abstract::The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198068

    authors: Eade OE,Maddison A,Leonard PJ,Wright R

    更新日期:1977-01-01 00:00:00

  • Guiding manometry probes into the human small bowel without X-ray: validation of a new technique.

    abstract:BACKGROUND:In order to perform small bowel manometry studies in man, the probes have to be guided through the upper gastrointestinal tract. This is usually controlled by fluoroscopy, but a method that allows to place the tubes without X-rays is obviously desirable. METHODS:A new method that controls tube placing by so...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000123841

    authors: V Schönfeld J

    更新日期:2008-01-01 00:00:00

  • The Ameliorating Effect of Switching to Vonoprazan: A Novel Potassium-Competitive Acid Blocker in Patients with Proton Pump Inhibitor Refractory Non-Erosive Reflux Disease.

    abstract:INTRODUCTION:Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present st...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000506152

    authors: Abe Y,Koike T,Saito M,Okata T,Nakagawa K,Hatta W,Asanuma K,Uno K,Asano N,Imatani A,Masamune A

    更新日期:2020-02-14 00:00:00

  • Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.

    abstract:BACKGROUND AND AIM:A recent basic study identified that Dicer is contained in exosomes derived from cancer cells and plays crucial roles in microRNA maturation and cancer development. Based on this novel basic concept, we analyzed the usefulness of serum exosomal Dicer as a diagnostic biomarker for gastrointestinal can...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000510993

    authors: Okuda Y,Shimura T,Iwasaki H,Katano T,Kitagawa M,Nishigaki R,Fukusada S,Natsume M,Tanaka M,Nishie H,Ozeki K,Yamada T,Kataoka H

    更新日期:2020-10-13 00:00:00

  • Gastric cancer development after Helicobacter pylori eradication therapy: a new form of gastric neoplasia.

    abstract:BACKGROUND AND AIM:Along with the widespread use of eradication for Helicobacter pylori (H. pylori), the incidence of gastric cancer after eradication has also been increasing. There is a need for clarification of the clinical and biological characteristics of these neoplasms. PATIENTS AND METHODS:We studied 27 cases ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000335260

    authors: Matsuo T,Ito M,Tatsugami M,Boda T,Takata S,Tanaka S,Chayama K

    更新日期:2012-01-01 00:00:00

  • What is the maximal effective dose of caerulein in stimulating pancreatic secretion in man?

    abstract::The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199357

    authors: Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

    更新日期:1986-01-01 00:00:00

  • Stimulation of disaccharidase activities in the jejunal brush border membrane of adult rat by total parenteral nutrition. Effects of thyroid hormones.

    abstract::This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the vill...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199030

    authors: Raul F,Galluser M,Doffoel M

    更新日期:1984-01-01 00:00:00

  • Effects of pirenzepine and atropine on amylase response to various secretagogues from the rat pancreatic acini.

    abstract::CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199415

    authors: Jaworek J,Konturek SJ

    更新日期:1987-01-01 00:00:00

  • Evaluation of GERD symptoms during therapy. Part II. Psychometric evaluation and validation of the new questionnaire ReQuest in erosive GERD.

    abstract:BACKGROUND/AIMS:Evaluation of the response of gastroesophageal reflux disease (GERD) symptoms to treatment would be facilitated by a brief, valid, reliable and responsive, self-assessed GERD-sensitive scale. We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluatio...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000079708

    authors: Mönnikes H,Bardhan KD,Stanghellini V,Berghöfer P,Bethke TD,Armstrong D

    更新日期:2004-01-01 00:00:00

  • Human chorionic gonadotropin-beta in the differentiation of malignancy-related and nonmalignant ascites.

    abstract::The clinical value of the tumor marker human chorionic gonadotropin-beta (hCG-beta) in ascitic fluid for the differentiation of malignancy-related and non-malignant ascites was evaluated. Ascitic fluid protein, cholesterol and cytological examination were determined for comparison. Thirty-six patients with malignancy-...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201324

    authors: Gerbes AL,Hoermann R,Mann K,Jüngst D

    更新日期:1996-01-01 00:00:00

  • Pharmacological treatment of the irritable bowel syndrome and other functional bowel disorders.

    abstract::Functional digestive disorders constitute one of the main causes of consultation in gastroenterology and primary health care. Is still unclear whether therapy has to be aimed to the gut, to the neural pathways controlling bowel motility and perception, or to the processing mechanisms of symptoms and disease behaviour....

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000089777

    authors: Mearin F

    更新日期:2006-01-01 00:00:00