Abstract:
BACKGROUND/AIMS:Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS. METHODS:IBS patients of the diarrhea-predominant (IBS-D) and of the constipation-predominant subgroup (IBS-C), patients with inactive UC and healthy subjects were enrolled. Gut permeability was evaluated by measuring 24-hour urine excretion of orally administered (51)Cr-EDTA. Clinical symptoms were evaluated in IBS-D patients and correlated to colonic permeability. RESULTS:There was a significant decrease in the proximal small intestinal permeability in IBS-C patients compared to controls (0.26 ± 0.05 vs. 0.63 ± 0.1%; p < 0.05). Distal small intestinal permeability showed no significant difference in the studied group of patients compared to controls. Colonic permeability of IBS-D and inactive UC patients was significantly increased compared to controls (2.68 ± 0.35 and 3.74 ± 0.49 vs. 1.04 ± 0.18%; p < 0.05, p < 0.001). Colonic permeability of IBS-D patients correlated with stool frequency. CONCLUSIONS:Elevated gut permeability is localized to the colon both in IBS-D and in inactive UC patients.
journal_name
Digestionjournal_title
Digestionauthors
Gecse K,Róka R,Séra T,Rosztóczy A,Annaházi A,Izbéki F,Nagy F,Molnár T,Szepes Z,Pávics L,Bueno L,Wittmann Tdoi
10.1159/000333083subject
Has Abstractpub_date
2012-01-01 00:00:00pages
40-6issue
1eissn
0012-2823issn
1421-9867pii
000333083journal_volume
85pub_type
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