What is the maximal effective dose of caerulein in stimulating pancreatic secretion in man?

abstract：:We previously reported that numerous macrophages which phagocytosed dextran sulfate sodium were observed to have accumulated in the mucosal lesions and in the spleen in experimental ulcerative colitis induced in mice with dextran sulfate sodium. In this paper, we investigated the bacterial phagocytic ability of macrop...

journal_title：Digestion

authors： Ohkusa T,Okayasu I,Tokoi S,Araki A,Ozaki Y

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Current treatment strategies of variceal bleeding (VB) include banding and sclerotherapy. However, up to 10% of bleeding events remain refractory to standard therapy with high mortality. With this study, we aimed to evaluate the implantation of self-expanding metal stents (SEMS) for the management o...

journal_title：Digestion

authors： Dechêne A,El Fouly AH,Bechmann LP,Jochum C,Saner FH,Gerken G,Canbay A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:What naturally happens to patients after they undergo conservative and endoscopic treatment of colonic diverticular bleeding (CDB) is largely unknown. We retrospectively track the long-term outcome of the recurrence of CDB between patients with endoscopic and conservative treatment. METHODS:The group wa...

journal_title：Digestion

authors： Mizuki A,Tatemichi M,Nakazawa A,Tsukada N,Nagata H,Kanai T

更新日期：2016-01-01 00:00:00

abstract：:A young woman with long-standing inflammatory bowel disease presented with a tender left gastrocnemius myositis in association with an exacerbation of her disease. Muscle biopsy showed a chronic inflammatory cell infiltrate and atrophic muscle fibres, but no granulomata or vasculitis, and her symptoms responded to hig...

journal_title：Digestion

authors： Hall MJ,Thomas WE,Cooper BT

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocyt...

journal_title：Digestion

authors： Ashraf H,Beltinger J,Alam NH,Bardhan PK,Faruque AS,Akter J,Salam MA,Gyr N

更新日期：2007-01-01 00:00:00

abstract：:Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...

journal_title：Digestion

authors： McMahon MJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Supramaximal concentrations of cholecystokinin (CCK) or cerulein induce the intracellular activation of trypsinogen and the transcription factor NF-kappaB, a key regulator of inflammatory gene expression. Both events occur early in the development of an acute pancreatitis. The aim of this study was ...

journal_title：Digestion

authors： Tando Y,Algül H,Schneider G,Weber CK,Weidenbach H,Adler G,Schmid RM

更新日期：2002-01-01 00:00:00

abstract：:In chronic pancreatitis the exocrine pancreatic tissue is replaced by extracellular matrix deposits from fibroblasts. We have stimulated fibrogenesis in the pancreas by inducing a single episode of cerulein pancreatitis (10 microg/kg/h for 12 h). We have used a spectrophotometrical assay to measure the tissue hydroxyp...

journal_title：Digestion

authors： Weidenbach H,Lerch MM,Turi S,Bachem M,Adler G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the diagnostic variability and reproducibility of endoscopic signs in two populations with a different pretest likelihood of celiac disease (CD). METHODS:We recruited 289 CD patients (both adults and children) in a multicenter prospective study. Group 1 (high risk) included 111 patients re...

journal_title：Digestion

authors： Pellegrino S,Furfaro F,Tortora A,Naso P,D'Agate C,Spina M,Belluardo N,Bertone A,Passanisi G,Malandrino S,Familiari L,Villanacci V,Puzzo L,Tuccari G,Sciacca A,Vieni G,Costa S,Currò G,Magazzù G,Sferlazzas C,Bassotti

更新日期：2013-01-01 00:00:00

abstract：:A statistical study was carried out to determine if fasting serum bile acid levels are clinically useful in differentiating children with chronic persistent hepatitis from children with chronic aggressive hepatitis. Serum bile acid levels were determined in 27 patients with chronic aggressive hepatitis, 41 with chroni...

journal_title：Digestion

authors： Jara P,Codoceo R,Hernanz A,Castaño C,Diaz C,Montero JL,Vázquez C

更新日期：1983-01-01 00:00:00

abstract：:The effects of somatostatin on cholera toxin-induced secretory diarrhea and the appearance of glycoenzymes in the intestinal lumen and intestinal lymph were investigated in rat small intestine. After exposure to cholera toxin, marked fluid accumulation in the small intestinal tract and elevation of the jejunal mucosal...

journal_title：Digestion

authors： Yoshioka M,Asakura H,Hamada Y,Miura S,Kobayashi K,Morishita T,Morita A,Tsuchiya M

更新日期：1987-01-01 00:00:00

abstract：:Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negati...

journal_title：Digestion

authors： Frisón JC,Ras MR,Rubiés-Prat J,Salvá JA,Masdeu S,Bacardí R

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND/AIMS:Colorectal cancer (CRC) patients are at high risk for developing extracolorectal malignancies (EMs). Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not be...

journal_title：Digestion

authors： Kawai K,Ishihara S,Nozawa H,Hata K,Kiyomatsu T,Tanaka T,Nishikawa T,Otani K,Yasuda K,Murono K,Sasaki K,Watanabe T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acotiamide, a prokinetic drug, is used to treat functional dyspepsia (FD), especially postprandial distress syndrome (PDS). However, a treatment for FD patients with PDS and/or epigastric pain syndrome (EPS) has not been established. We investigated the efficacy of famotidine in combination with acotiam...

journal_title：Digestion

authors： Hojo M,Nagahara A,Asaoka D,Takeda T,Izumi K,Matsumoto K,Ueyama H,Shimada Y,Matsumoto K,Nojiri S,Watanabe S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a median 5-year survival of <8%. At the time of diagnosis, a vast majority of pancreatic cancer patients were found to be with either metastatic spread of the disease or locally advanced tumors. Despite relatively low efficacy, ge...

journal_title：Digestion

authors： Ellenrieder V,König A,Seufferlein T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Symptoms caused by chronic pancreatitis (CP) are common but often elusive hampering therapeutic decisions. Though correlations of morphologic findings in imaging and clinical appearance remain vague. We aimed in investigating whether a distinct combination of clinical parameters can better define the extent ...

journal_title：Digestion

authors： Perkhofer L,Besold T,Schmidberger J,Seufferlein T,Hann A,Müller M,Kleger A

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND/AIM:Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most ...

journal_title：Digestion

authors： van Kerkhoven LA,van Rijswijck SJ,van Rossum LG,Laheij RJ,Witteman EM,Tan AC,Jansen JB

更新日期：2007-01-01 00:00:00

abstract：:Rabbit duodenal and jejunal brush-border membrane vesicle integrity, fluidity and passive proton permeability were studied after in vitro exposure to deoxycholate, glycodeoxycholate or taurodeoxycholate. Duodenal and jejunal membrane mean vesicle volume [0.54 (0.05) and 0.54 (0.03) microliters/mg, mean values with SE ...

journal_title：Digestion

authors： Zhao DL,Hirst BH

更新日期：1990-01-01 00:00:00

abstract：:The diagnostic value of serum ferritin levels was evaluated in 19 patients with biopsy-proven primary hepatocellular carcinoma (PHC) and 26 patients with chronic liver disease (CLD). Serum ferritin levels were significantly elevated in PHC, as compared with CLD and controls (p less than 0.0005). Similarly, serum ferri...

journal_title：Digestion

authors： Giannoulis E,Arvanitakis C,Nikopoulos A,Doutsos I,Tourkantonis A

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND/AIMS:In the human stomach various alcohol dehydrogenase (ADH) isoenzymes exist. The gastric ADH activity is affected by a number of factors including also the infection of Helicobacter pylori. The objective was to investigate the activity of alcohol dehydrogenase isoenzymes of class I, III and IV in endoscop...

journal_title：Digestion

authors： Chrostek L,Jelski W,Szmitkowski M,Laszewicz W

更新日期：2002-01-01 00:00:00

abstract：:Groups of Sprague-Dawley rats were given placebo or prostaglandin E2 (PGE2) at 25 or 5,000 micrograms/kg or 15,R,15-methyl-PGE2 (MePGE2) at 5 or 50 micrograms/kg, twice daily, orally, for 1 month. Histological sections from the proximal duodenum were processed for immunohistochemistry and the volume density of immunor...

journal_title：Digestion

authors： Kapraali M,Söderman C,Marín L,Johansson O,Theodorsson E,Uribe A

更新日期：1997-01-01 00:00:00

abstract：:Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, ...

journal_title：Digestion

authors： Hoofnagle JH

更新日期：1998-08-01 00:00:00

abstract：:23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...

journal_title：Digestion

authors： Bernardi M,Servadei D,Trevisani F,Rusticali AG,Gasbarrini G

更新日期：1985-01-01 00:00:00

abstract：:This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Piastucki I,Radecki T

更新日期：1983-01-01 00:00:00

abstract：:The isoenzymatic pattern of aldolase was determined by immunoprecipitation with specific anti-aldolase A, B and C sera in 21 pathological liver tissues and in the sera of normals (n equals 20), liver cirrhotics (n equals 52) and hepatoma patients (n equals 22). The increase of aldolase A in primary liver cell carcinom...

journal_title：Digestion

authors： Lehmann FG,Kornacher J

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed at (i) clarifying the factors associated with high scores on the modified frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) among 3,505 relatively healthy subjects undergoing routine medical health checkups with gastrointestinal endoscopy and (ii) comparing risk...

journal_title：Digestion

authors： Takeshita E,Sakata Y,Hara M,Akutagawa K,Sakata N,Endo H,Ohyama T,Matsunaga K,Yoshioka T,Kawakubo H,Tanaka Y,Shirai S,Ito Y,Tsuruoka N,Iwakiri R,Kusano M,Fujimoto K

更新日期：2016-01-01 00:00:00

abstract：:A highly significant increase in net fluxes across the guinea-pig small intestine for both 45Ca2+ and 35SO4(2-), in the presence of cystic fibrosis plasma compared with non-cystic fibrosis plasma, was observed (p less than 0.001). In the presence of cystic fibrosis plasma, the nuclear, mitochondrial, microsomal and so...

journal_title：Digestion

authors： Morrissey SM,Mehta JG

更新日期：1986-01-01 00:00:00

abstract：:Lithium is a cation which has central nervous system effects and is able to interfere with both the release and action of polypeptide hormones. We examined its effect on basal and stimulated plasma gastrin and pancreatic polypeptide (PP) levels in 4 dogs with chronic gastric fistulas. Gastrin and PP release were stimu...

journal_title：Digestion

authors： Modlin IM,Ehrlich BE,Lamers CB,Diamond JM,Walsh JH

更新日期：1981-01-01 00:00:00

abstract：AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

journal_title：Digestion

authors： Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy for advanced gastric cancer is expected to improve prognoses. However, as there is no method to evaluate neoadjuvant chemotherapeutic efficacy before gastrectomy, some patients at high risk for a poor prognosis undergo gastrectomy. The aim of the present study was to investigate whet...

journal_title：Digestion

authors： Sugawara N,Ota K,Terazawa T,Tanaka R,Akutagawa H,Yamaguchi T,Imai Y,Harada S,Kojima Y,Tashiro K,Kii T,Lee SW,Kawai M,Egashira Y,Goto M,Uchiyama K,Hirose Y,Takeuchi T,Higuchi K

更新日期：2020-01-01 00:00:00