Abstract:
:A statistical study was carried out to determine if fasting serum bile acid levels are clinically useful in differentiating children with chronic persistent hepatitis from children with chronic aggressive hepatitis. Serum bile acid levels were determined in 27 patients with chronic aggressive hepatitis, 41 with chronic persistent hepatitis and 55 control children. Several other biochemical tests of liver function were also determined in these children. There were significant differences in the mean fasting serum bile acid levels between chronic hepatitis patients and control children (p less than 0.001). These levels were significantly higher for the chronic aggressive group than the chronic persistent hepatitis group (p less than 0.001). Other biochemical 'hepatic function' tests did not show statistically different values between these two groups. Using stepwise discriminant analysis for the biochemical 'liver function' tests studied, only serum bile acid levels are able to distinguish statistically between chronic aggressive hepatitis and chronic persistent hepatitis children. These data suggest that fasting serum bile acid levels may have clinical utility in identifying children with asymptomatic chronic hepatitis and differentiating between chronic aggressive hepatitis and chronic persistent hepatitis children.
journal_name
Digestionjournal_title
Digestionauthors
Jara P,Codoceo R,Hernanz A,Castaño C,Diaz C,Montero JL,Vázquez Cdoi
10.1159/000198934subject
Has Abstractpub_date
1983-01-01 00:00:00pages
81-6issue
2eissn
0012-2823issn
1421-9867journal_volume
27pub_type
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