Pentoxifylline accelerates gastric ulcer healing in rats: roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing.

abstract：:Fragments of benign colonic adenomatous polyps of man, adenocarcinoma of the colon of man, and normal colonic mucosa of man and rodent were transplanted under the kidney capsule of athymic mice. Benign human adenomatous cells survived for periods of up to 28 days, normal rodent colonic epithelial cells for 45 days and...

journal_title：Digestion

authors： Bhargava DK,Lipkin M

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...

journal_title：Digestion

authors： Bohr J,Järnerot G,Tysk C,Jones I,Eriksson S

更新日期：2002-01-01 00:00:00

abstract：:The potential therapeutic applications of somatostatin and octreotide in gastroenterology involve gut neuro-endocrine tumours, bleeding varices, bleeding peptic ulcers, gastro-intestinal fistulae, pancreatic fistulae, dumping syndrome, pancreatic pseudocysts, short bowel syndrome, acute pancreatitis, AIDS-related diar...

journal_title：Digestion

authors： Burroughs AK,Malagelada R

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present st...

journal_title：Digestion

authors： Abe Y,Koike T,Saito M,Okata T,Nakagawa K,Hatta W,Asanuma K,Uno K,Asano N,Imatani A,Masamune A

更新日期：2020-02-14 00:00:00

abstract：:The elimination kinetics of antipyrine have been established under basal environmental conditions in 6 healthy volunteers. Concentrations of antipyrine in serum were measured by a relatively fast high-pressure liquid chromatography method using a radial-compression chromatographic system. Pretreatment of the subjects ...

journal_title：Digestion

authors： Paxton JW,Foote SE,Paton DM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Cholangiocarcinoma (CCA) is the most common hepatobiliary malignancy complicating primary sclerosing cholangitis (PSC). Unfortunately, timely diagnosis of CCA in PSC patients remains challenging. AIM:To investigate the strategies among liver centers regarding pre-transplant screening for CCA in patients wit...

journal_title：Digestion

authors： Trilianos P,Selaru F,Li Z,Gurakar A

更新日期：2014-01-01 00:00:00

abstract：:We studied the functional coupling between antral somatostatin and gastrin cells in pigs using isolated perfused preparations of the antrum with intact supply of the vagus nerves. Luminal acidification significantly inhibited gastrin secretion to 61 +/- 3% of basal secretion and increased somatostatin output 9-fold. I...

journal_title：Digestion

authors： Holst JJ,Orskov C,Seier-Poulsen S

更新日期：1992-01-01 00:00:00

abstract：:The rates of intracellular transport of newly synthesized amylase, lipase, trypsinogen and chymotrypsinogen were compared in the anaesthesized rat pancreas by measuring their rates of secretion while keeping their relative rates of synthesis in a steady state. It is concluded that pancreatic proteins are not transport...

journal_title：Digestion

authors： Iovanna J,Giorgi D,Dagorn JC

更新日期：1986-01-01 00:00:00

abstract：:The effects of gastric fundectomy and antrectomy on the colonic mucosa were studied in hamsters over 5 and 25 days. Sham-operated animals served as controls. Basal plasma gastrin concentrations were significantly increased after fundectomy and significantly decreased after antrectomy. Five days after fundectomy, there...

journal_title：Digestion

authors： Chu M,Rehfeld JF,Borch K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The exact etiology of irritable bowel syndrome (IBS) remains unclear. Curative treatment is not available and current treatment modalities are mainly directed against the predominant symptoms. There are a few studies reporting the beneficial effects of transcutaneous electrical stimulation in patients with c...

journal_title：Digestion

authors： Coban Ş,Akbal E,Köklü S,Köklü G,Ulaşlı MA,Erkeç S,Aktaş B,Yüksel O,Koçak E,Erdem HR

更新日期：2012-01-01 00:00:00

abstract：:Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negati...

journal_title：Digestion

authors： Frisón JC,Ras MR,Rubiés-Prat J,Salvá JA,Masdeu S,Bacardí R

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies (IMT). However, the underlying UC remained active in some UC patients, despite the fact that CMV-DNA in colonic mucosa became negative after antiviral therapy. Therefore, new therapeutic strategies f...

journal_title：Digestion

authors： Yoshino T,Nakase H,Matsuura M,Matsumura K,Honzawa Y,Fukuchi T,Watanabe K,Murano M,Tsujikawa T,Fukunaga K,Matsumoto T,Chiba T

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) is recognized as a minimally invasive and curative treatment for superficial gastrointestinal (GI) cancers. However, ESD is still challenging and time-consuming with a high risk of adverse events such as bleeding and perforation. Various traction methods have been explo...

journal_title：Digestion

authors： Kaku H,Toyonaga T,Tanaka S,Takihara H,Baba S,Tsubouchi E,Ikeda Y,Orita H,Nakamoto M,Horikawa Y,Chiba H,Ban H,Furumoto Y,Morita R,Kodama Y

更新日期：2020-12-22 00:00:00

abstract：:25 missionaries working in Taiwan, Thailand, Indonesia and the Philippines completed questionnaires regarding their clinical practice during the year 1980. Data were collected on the numbers of both gastric and colorectal cancers diagnosed. More than 90,000 out-patients were reviewed, and over 25,000 in-patients treat...

journal_title：Digestion

authors： Hart AR,Mann R,Mayberry JF

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to analyze the endoscopic mucosal resection (EMR) with a novel uniquely shaped, double-loop snare (Dualoop, Medico's Hirata Inc., Tokyo, Japan) for colorectal polyps. METHODS:This was a clinical trial conducted in two referral centers, Kyoto Prefectural University of Medicine and Natio...

journal_title：Digestion

authors： Yoshida N,Saito Y,Hirose R,Ogiso K,Inada Y,Yagi N,Naito Y,Otake Y,Nakajima T,Matsuda T,Yanagisawa A,Itoh Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:The aim of this study was to exactly determine the pH stability of human gastric lipase (HGL) and to investigate the mechanism underlying the inactivation of HGL which occurs in gastric juice. METHODS:Samples of human gastric juice and purified HGL were incubated at various pH values ranging from 0.5 t...

journal_title：Digestion

authors： Ville E,Carrière F,Renou C,Laugier R

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Colonic diverticulosis is a common condition with obscure pathogenesis. Obesity, hyperlipidemia and hypertension have been demonstrated to increase the risk of complicated diverticular disease, but the impact of metabolic risk factors on the prevalence of uncomplicated diverticulosis has not been clearly d...

journal_title：Digestion

authors： Kopylov U,Ben-Horin S,Lahat A,Segev S,Avidan B,Carter D

更新日期：2012-01-01 00:00:00

abstract：:Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed rats. The middle third of the crypt was the area stimulated to contribute the ...

journal_title：Digestion

authors： Deschner EE,Cohen BI,Raicht RF

更新日期：1981-01-01 00:00:00

abstract：:This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Piastucki I,Radecki T

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Transition-related healthcare intervention has recently been receiving worldwide attention. Given the increasing incidence of pediatric inflammatory bowel disease (IBD) and its lifelong impact, transitional care has become an important issue. In Japan, guidelines to support the autonomy of IBD patients durin...

journal_title：Digestion

authors： Kumagai H,Suzuki Y,Shimizu T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Prevention of Helicobacter pylori infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no immunization protocol has been accepted for humans. A better characterization of the i...

journal_title：Digestion

authors： Lazowska I,Trzeciak L,Godlewska R,Hennig E,Jagusztyn-Krynicka K,Popowski J,Regula J,Ostrowski J

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...

journal_title：Digestion

authors： Sakai M,Sohda M,Saito H,Ubukata Y,Nakazawa N,Kuriyama K,Hara K,Sano A,Ogata K,Yokobori T,Kuwano H,Shirabe K,Saeki H

更新日期：2020-10-08 00:00:00

abstract：:Recent studies have demonstrated the presence of both CCKA and CCKB receptors on dog and guinea pig pancreas. Although CCKA receptors are implicated in enzymatic secretion, biological effects of CCKB receptors are still unknown. We have previously found that a rat acinar pancreatic cell line (AR4-2J) possesses both re...

journal_title：Digestion

authors： Seva C,De Vries L,Scemama JL,Sarfati P,Nicolet TG,Pradayrol L,Vaysse N

更新日期：1990-01-01 00:00:00

abstract：:We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...

journal_title：Digestion

authors： Ahlman H

更新日期：1996-01-01 00:00:00

abstract：:Since arginine can stimulate lymphocyte proliferation in the healthy human, its effect on lymphocyte proliferation in vitro was studied in 7 patients with far advanced gastric cancer. These patients with normal nourishment were ambulatory and could consume a regular diet. A daily dietary supplement of 30 g arginine fo...

journal_title：Digestion

authors： Wu CW,Chi CW,Chiu CC,Wu HS,Liu WY,P'eng FK,Wang SR

更新日期：1993-01-01 00:00:00

abstract：:Growth hormone-releasing factor (GRF) was reported to possess the growth-promoting action on the gastroduodenal mucosa that can be augmented by removal of endogenous somatostatin. Since mucosal proliferation was considered to contribute to healing of chronic gastroduodenal ulcerations, we designed the study to determi...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Dembinski A,Warzecha Z,Konturek PK,Yanaihara N

更新日期：1988-01-01 00:00:00

abstract：:Carbonic anhydrase (CA) was found to be equally susceptible to direct inhibition by ethanol, whether the enzyme originated from homogenates of rabbit gastric, duodenal, or ileal mucosa. When gastric mucosa was separated into a soluble (cytoplasmic) and a membrane fraction, the membrane CA was more susceptible to ethan...

journal_title：Digestion

authors： Newsome LR,Leitch GJ

更新日期：1978-07-01 00:00:00

abstract：:The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 ...

journal_title：Digestion

authors： Wereszczyńska-Siemiatkowska U,Pohl U,Otto J,Lankisch PG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to examine the relationship between narrow-band imaging (NBI) magnifying observation using the surface pattern as the main evaluation criterion and pit pattern diagnosis on the basis of magnifying observation using a dye in relation to the characteristics of colorectal tumors ac...

journal_title：Digestion

authors： Hayashi N,Tanaka S,Kanao H,Oka S,Yoshida S,Chayama K

更新日期：2013-01-01 00:00:00

abstract：:Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...

journal_title：Digestion

authors： McMahon MJ

更新日期：1993-01-01 00:00:00