Abstract:
:We have shown that dietary long-chain triglycerides and 16,16-dimethyl prostaglandin E2 enhance and aspirin impairs postresection mucosal adaptation in rats. The present studies examined the hypothesis that supplemental linoleic acid (LA) above the minimum requirement may enhance postresection mucosal adaptation through altered prostaglandin (PG) synthesis. Forty male Sprague-Dawley rats (105 +/- 5 g) were fed purified diet containing either 5% LA or 4% palmitic acid and 1% LA. After 2 weeks, 12 rats from each dietary group underwent 70% proximal jejunoileal resection and the remainder were sham-operated. Dietary regimens were continued for an additional 13 days. Mucosal fatty acid analysis of 1% LA group revealed a ratio of 20:3 n-9/20:4 n-6 lower than 0.2, indicating normal essential fatty acid status. Mucosal protein per centimeter bowel was higher in the 5% LA group compared to the 1% group, but mucosal DNA, maltase, and ex vivo PG synthesis were not affected. These results indicate that LA stimulates postresection mucosal hypertrophy, which does not appear to be related to PG synthesis.
journal_name
Digestionjournal_title
Digestionauthors
Park JH,Grandjean CJ,Hart MH,Baylor JM,Vanderhoof JAdoi
10.1159/000199893subject
Has Abstractpub_date
1989-01-01 00:00:00pages
57-65issue
2eissn
0012-2823issn
1421-9867journal_volume
44pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510353
更新日期:2020-10-08 00:00:00
abstract::Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was ass...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200714
更新日期:1991-01-01 00:00:00
abstract::Several previous studies have shown that the plasma concentration of gamma-amino-butyric acid (GABA) is markedly increased in patients with hepatic encephalopathy, and it has been suggested that decreased metabolism of peripheral GABA might contribute to the cerebral dysfunctions observed. In the present study, plasma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200724
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Different food items are made responsible for irritable bowel syndrome (IBS) symptoms, but the physiopathology of IBS remains unclear. AIMS:During a meeting in Nice, France, experts of the European Working Team of the IBiS Club discussed selected data regarding the relationships between alimentation, food i...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000072061
更新日期:2003-01-01 00:00:00
abstract:AIMS:To evaluate the prevalence of proximal reflux and esophago-bronchial reflex (EBR) in patients with asthma, and to compare the symptom spectrum, esophageal acid sensitivity, pH monitoring, and the endoscopic and manometric parameters of EBR-positive and -negative patients with asthma. PATIENTS AND METHODS:Forty-th...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000146083
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The aim of this study was to see whether administration of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, could prevent the development of gastric cancer via inhibition of apurinic/apyrimidinic endonuclease-1 (APE-1) expression induced by Helicobacter pylori infection. METHODS:70 Mongol...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000167978
更新日期:2008-01-01 00:00:00
abstract::This study was designed to compare the influence of omeprazole, a potent inhibitor of H+/K+-ATP-ase involved in the final step of H+ secretion and prostaglandin (PG) I2 on the formation of gastric mucosal lesions induced by absolute ethanol or acidified aspirin (ASA). Omeprazole given intragastrically in both inhibito...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198946
更新日期:1983-01-01 00:00:00
abstract::Repeated intravenous injections of 2.0 clinical units (CU) secretin per kg body weight showed no effect on jejunal glucose absorption and net water movement in perfusion studies in vivo. The in vitro uptake of galactose and 3-O-methylglucose was not altered by a secretin load given 12 min before sacrifice. The values ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197730
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND/AIMS:Only the depth of submucosal invasion can be estimated prior to determining the indications for endoscopic submucosal dissection (ESD) as a curative treatment for colorectal carcinoma (CRC). Here we evaluated the outcomes of ESD for clinical T1 CRCs. METHODS:Of 660 patients who underwent ESD for CRC at...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000368866
更新日期:2015-01-01 00:00:00
abstract::Functional digestive disorders constitute one of the main causes of consultation in gastroenterology and primary health care. Is still unclear whether therapy has to be aimed to the gut, to the neural pathways controlling bowel motility and perception, or to the processing mechanisms of symptoms and disease behaviour....
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000089777
更新日期:2006-01-01 00:00:00
abstract::A highly significant increase in net fluxes across the guinea-pig small intestine for both 45Ca2+ and 35SO4(2-), in the presence of cystic fibrosis plasma compared with non-cystic fibrosis plasma, was observed (p less than 0.001). In the presence of cystic fibrosis plasma, the nuclear, mitochondrial, microsomal and so...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199307
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Intravenous iron and erythropoietin have been shown to be effective in Crohn's disease-associated anemia. The aim of this study was to test the sequential treatment of anemia in ulcerative colitis with intravenous iron in the first phase and erythropoietin in the second. PATIENTS AND METHODS:Twenty patients...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000007667
更新日期:1999-01-01 00:00:00
abstract::Retractile mesenteritis is an extremely rare disease characterised by a non-specific inflammatory and fibrotic process of the mesenteric adipose tissue, which is usually accompanied by pain and a variety of other abdominal symptoms. We describe here the case of a patient with retractile mesenteritis presenting with pr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007748
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM:To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS:Prepubertal children of ages 3-12 with either la...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000381895
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Recently, several studies have demonstrated the usefulness of endoscopic submucosal dissection (ESD) for residual or locally recurrent colorectal lesions after endoscopic treatment. However, the feasibility of ESD for recurrent rectal lesions after transanal endoscopic microsurgery (TEM) has not been fully i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000505619
更新日期:2020-02-05 00:00:00
abstract:BACKGROUND/AIMS:In this report, we aimed to investigate the distribution and characterization of biomarker-immunolabeled ductal epithelium in advanced pancreatic ductal adenocarcinoma (PDAC). DESIGN:Eighteen patients with PDAC were medically diagnosed prior to being treated periodically. All clinical records were coll...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000492861
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:At present, benefits of surgical resection and appropriate selection criteria in patients affected by both hepatic and pulmonary metastases of colorectal cancer (CRC) are under discussion. Our analysis focused on a surgical series of such patients and our final aim consisted in identifying potential pro...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000497223
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS:An expert international group using the modified Delphi technique examined the q...
journal_title:Digestion
pub_type: 共识发展会议,杂志文章
doi:10.1159/000219365
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Evaluation of the response of gastroesophageal reflux disease (GERD) symptoms to treatment would be facilitated by a brief, valid, reliable and responsive, self-assessed GERD-sensitive scale. We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluatio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000079708
更新日期:2004-01-01 00:00:00
abstract::Non-erosive reflux disease (NERD) has assumed increasing prominence in studies of gastroesophageal reflux disease (GERD), but it remains a challenge to define NERD precisely and to define its place in the investigation and treatment of GERD. Most simply, NERD may be defined as GERD in an individual who has no evidence...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000151255
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000464130
更新日期:2017-01-01 00:00:00
abstract::A 3 years evolution with amyloid involvement, primarily of the liver, in a patient is described. This led to intrahepatic cholestasis and to portal hypertension with esophageal varices. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198459
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Current treatment strategies of variceal bleeding (VB) include banding and sclerotherapy. However, up to 10% of bleeding events remain refractory to standard therapy with high mortality. With this study, we aimed to evaluate the implantation of self-expanding metal stents (SEMS) for the management o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000335081
更新日期:2012-01-01 00:00:00
abstract::This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198975
更新日期:1983-01-01 00:00:00
abstract::Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199226
更新日期:1985-01-01 00:00:00
abstract::Gastro-oesophageal reflux disease (GORD) is a chronic illness causing recurrent typical and atypical symptoms. Possible complications include oesophagitis, ulcer, stricture and Barrett's oesophagus. Evidence suggests that the intraoesophageal pH correlates directly with the degree of mucosal injury. Proton pump inhibi...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000076371
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a median 5-year survival of <8%. At the time of diagnosis, a vast majority of pancreatic cancer patients were found to be with either metastatic spread of the disease or locally advanced tumors. Despite relatively low efficacy, ge...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000447739
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS:In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations we...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007634
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to exactly determine the pH stability of human gastric lipase (HGL) and to investigate the mechanism underlying the inactivation of HGL which occurs in gastric juice. METHODS:Samples of human gastric juice and purified HGL were incubated at various pH values ranging from 0.5 t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000057708
更新日期:2002-01-01 00:00:00
abstract::Diamine oxidase (DAO) is an enzyme located almost exclusively in the villus tip enterocytes of mammals. Its plasma activity, normally very low, is enhanced by intravenous heparin that releases the enzyme from the enterocytes into the blood. Postheparin plasma DAO (PHD) values have been shown to be significantly reduce...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199731
更新日期:1988-01-01 00:00:00