Glucagon, secretin and vasoactive intestinal polypeptide immunoreactivities in rat gut after jejuno-ileal bypass and resection.

Abstract:

:Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivities were measured in extracts of gut tissues including formerly adjacent segments of functional and bypassed jejunum and ileum. Young adult (200-220 g) and mature (404-440 g) rats received greater than 90% JIB. Though slight differences were observed in the response of the young and old rats to the operations, and between the effects of JIB and resection, the results do not indicate major involvement of secretin, VIP or gut glucagon-like immunoreactivity in the effects of surgery. Changes include increased immunoreactivity of secretin in the upper and of VIP in the lower functional gut following JIB. N-terminal-to central glucagon immunoreactivity in the functional ileum did not change substantially after operations, but was significantly lower in the non-functional than functional ileum after bypass. Plasma levels of this immunoreactivity were higher following operations and highest following resection.

journal_name

Digestion

journal_title

Digestion

authors

Murphy RF,Chen MH,Herlin PM,Gallavan RH,Joffe SN,Fischer JE

doi

10.1159/000199226

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

106-13

issue

2

eissn

0012-2823

issn

1421-9867

journal_volume

32

pub_type

杂志文章
  • Modulation of growth of human gastric enterochromaffin-like cells.

    abstract::We consider the multiple interacting factors which lead to the proliferation of human gastric enterochromaffin-like (ECL) cells, and control of this proliferation by somatostatin and its analogues. Somatostatin receptors occur in human fundic mucosa, and octreotide can be considered a useful therapeutic tool to contro...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201386

    authors: Delle Fave G,Annibale B

    更新日期:1996-01-01 00:00:00

  • Effect of cystic fibrosis and non-cystic fibrosis plasma on 45Ca and 35SO4 uptake and retention by the small intestine at the cellular level in the guinea pig.

    abstract::A highly significant increase in net fluxes across the guinea-pig small intestine for both 45Ca2+ and 35SO4(2-), in the presence of cystic fibrosis plasma compared with non-cystic fibrosis plasma, was observed (p less than 0.001). In the presence of cystic fibrosis plasma, the nuclear, mitochondrial, microsomal and so...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199307

    authors: Morrissey SM,Mehta JG

    更新日期:1986-01-01 00:00:00

  • Plaunotol stimulates endogenous secretin release and exocrine pancreatic secretion in rats.

    abstract::The effect of the new antiulcer agent plaunotol on the release of endogenous secretin and the pancreatic exocrine secretion was investigated in anesthetized rats. In 48 rats with pancreatic and biliary diversion, continuous intraduodenal infusion of plaunotol in 3 graded doses (5, 20 and 80 mg/h/rat) resulted in signi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199903

    authors: Chang JH,Watanabe S,Shiratori K,Moriyoshi Y,Takeuchi T

    更新日期:1989-01-01 00:00:00

  • Hydrokinetic activity of secretion and secretin analogues, modified in the N-terminal sequence, and of vasoactive intestinal peptide in the dog pancreas.

    abstract::In the dog pancreas in vivo, the biological activity of secretin and vasoactive intestinal peptide was compared to that of secretin analogues modified in their N-terminal hexapeptide and to X-secretion (alpha, beta-Asp3-secretin) and Y-secretin (a conversion product of X-secretin consisting of about 15% secretin and 8...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198600

    authors: Lehnert P,Forell MM,Jaeger E,Moroder L,Wünsch E

    更新日期:1981-01-01 00:00:00

  • Multimicrobial sepsis including Clostridium perfringens after chemoembolization of a single liver metastasis from common bile duct cancer.

    abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007815

    authors: Eckel F,Lersch C,Huber W,Weiss W,Berger H,Schulte-Frohlinde E

    更新日期:2000-01-01 00:00:00

  • Inhibition of bile acid and water absorption by phenethylbiguanide in rat ileum in vivo.

    abstract::Since biguanides are known to inhibit hexose and amino acid absorption in vivo and in vitro as well as vitamin B12 absorption the effect of phenethylbiguanide on taurocholate (TC) and water absorption was measured in rat ileum in vivo. Phenethylbiguanide exhibited a time-dependent inhibitory effect on TC- and water ab...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197672

    authors: Caspary WF,Lücke H

    更新日期:1975-01-01 00:00:00

  • Evaluation of faecal occult blood test and lactoferrin latex agglutination test in screening hospitalized patients for diagnosing inflammatory and non-inflammatory diarrhoea in Dhaka, Bangladesh.

    abstract:BACKGROUND:Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocyt...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000113042

    authors: Ashraf H,Beltinger J,Alam NH,Bardhan PK,Faruque AS,Akter J,Salam MA,Gyr N

    更新日期:2007-01-01 00:00:00

  • Extensive small bowel resection in the rat: lack of effect on serum proteins.

    abstract::Rats were subjected to serial venesections 3 days prior to and then sequentially for 4 weeks after surgical removal of either the proximal or distal half of the small bowel. Total serum protein concentration and protein electrophoretic patterns were determined on these sera. Both sham-operated and unoperated animals s...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198408

    authors: Urban E,Ricks PM

    更新日期:1980-01-01 00:00:00

  • Effects of pirenzepine and atropine on amylase response to various secretagogues from the rat pancreatic acini.

    abstract::CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199415

    authors: Jaworek J,Konturek SJ

    更新日期:1987-01-01 00:00:00

  • EEG in ulcerative colitis.

    abstract::Electroencephalographic tracings of 50 patients with ulcerative colitis (UC) were compared with those of 75 controls. In the UC patients a 24% incidence of abnormal tracings was found as compared with an 8% incidence in the controls. A higher incidence of abnormal electroencephalograms was found among active cases of ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197695

    authors: Eschar J,Arlazoroff A,Kleinhaus M,Mera A,Gilat T,Weissman I

    更新日期:1975-01-01 00:00:00

  • A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan.

    abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000507570

    authors: Kudo T,Fujii T,Maisawa SI,Sasaki M,Uchida K,Ida S,Kagimoto S,Yoden A,Shimizu T

    更新日期:2020-05-18 00:00:00

  • Advantages of fecal lactoferrin measurement during granulocyte and monocyte adsorptive apheresis therapy in ulcerative colitis.

    abstract:BACKGROUND:Fecal lactoferrin has been introduced as a useful tool for the diagnosis and monitoring of inflammatory bowel disease (IBD). The aim of this study was to assess if fecal lactoferrin can be employed to predict or estimate the effect of granulocyte and monocyte adsorptive apheresis (GMA) in ulcerative colitis ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000375301

    authors: Hashiguchi K,Takeshima F,Akazawa Y,Matsushima K,Minami H,Machida H,Yamaguchi N,Shiozawa K,Ohba K,Ohnita K,Ichikawa T,Isomoto H,Nakao K

    更新日期:2015-01-01 00:00:00

  • Effect of CCK-octapeptide and secretin on amylase secretion in isolated rat pancreatic acinar cells.

    abstract::Isolated acinar cells from rat pancreas responded well to hormonal treatment. Both secretin (synthetic and highly purified from porcine origin) and CCK-octapeptide stimulated amylase secretion in these cells. The response in both cases was very rapid. A maximal output of enzyme was reached within 5-10 min after the ad...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198316

    authors: Lee PC

    更新日期:1979-01-01 00:00:00

  • Analysis of Wire-Guided Hemostasis Introducer for Percutaneous Therapy of Bile Duct Stones.

    abstract:BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000485179

    authors: Hollenbach M,Feisthammel J,Mössner J,Hoffmeister A

    更新日期:2018-01-01 00:00:00

  • Radiation pancreatitis: a clinical entity?

    abstract::2 cases of pancreatic disease in patients with malabsorption following small bowel radiation injury are reported. It is suggested that the pancreatic disease present in these patients occurred as a result of previous radiotherapy. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198334

    authors: Mitchell CJ,Simpson FG,Davison AM,Losowsky MS

    更新日期:1979-01-01 00:00:00

  • Special functional features of T-lymphocyte subpopulations in the effector compartment of the intestinal mucosa and their relation to mucosal transformation.

    abstract::Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal gr...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200398

    authors: Zeitz M,Schieferdecker HL,James SP,Riecken EO

    更新日期:1990-01-01 00:00:00

  • Adrenergic effects on secretion of amylase from the rat salivary glands.

    abstract::The present study was undertaken to investigate the effect of adrenergic agents on secretion of amylase from the salivary glands in vivo. Saliva was collected from the distal oesophagus in conscious rats. Adrenaline increased the concentration of amylase in saliva and serum significantly. The result of infusion of alp...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199729

    authors: Skov Olsen P,Kirkegaard P,Rasmussen T,Magid E,Poulsen SS,Nexø E

    更新日期:1988-01-01 00:00:00

  • Elimination of porcine heptadecapeptide gastrin (G17) and human leu big gastrin (G34) by the perfused pig liver.

    abstract::In order to study some of the molecular events during the hepatic passage of gastrin, we perfused sulfated natural porcine gastrin (G17 II) through isolated pig livers. The disappearance half time of G17 II was about 20-30 min when the starting gastrin concentrations were greater than 100 pM; lower concentrations were...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199029

    authors: Feurle GE,Winkler C,Encke A,Helmstaedter V,Doertenbach JG

    更新日期:1984-01-01 00:00:00

  • Absorption of bile acids in dog as determined by portal blood sampling: evidence for colonic absorption of bile acid conjugates.

    abstract::The intestinal phase of enterohepatic circulation, such as site and state of bile acid absorption, along the length of the intestinal tract has been speculated but not directly quantitated. In order to gain insight into the actual state of intestinal absorption of bile acid, the bile acid composition of portal blood f...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199790

    authors: Fujii T,Yanagisawa J,Nakayama F

    更新日期:1988-01-01 00:00:00

  • Gastric and colorectal cancer in patients attending mission hospitals in rural areas of South-east Asia.

    abstract::25 missionaries working in Taiwan, Thailand, Indonesia and the Philippines completed questionnaires regarding their clinical practice during the year 1980. Data were collected on the numbers of both gastric and colorectal cancers diagnosed. More than 90,000 out-patients were reviewed, and over 25,000 in-patients treat...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201034

    authors: Hart AR,Mann R,Mayberry JF

    更新日期:1993-01-01 00:00:00

  • Stimulation of disaccharidase activities in the jejunal brush border membrane of adult rat by total parenteral nutrition. Effects of thyroid hormones.

    abstract::This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the vill...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199030

    authors: Raul F,Galluser M,Doffoel M

    更新日期:1984-01-01 00:00:00

  • Helicobacter pylori, peptic ulcer disease and inhibition of gastric acid secretion.

    abstract::Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200908

    authors: Rune S

    更新日期:1992-01-01 00:00:00

  • Nutritional modulation of the inflammatory bowel response.

    abstract::Crohn's disease and ulcerative colitis represent distinct phenotypic forms of inflammatory bowel disease and continue to be a common cause of morbidity. The corticosteroids and the immunomodulatory drugs, which are the basis of treatment for the inflammatory bowel diseases, do not assure always satisfactory outcomes. ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000323456

    authors: Ioannidis O,Varnalidis I,Paraskevas G,Botsios D

    更新日期:2011-01-01 00:00:00

  • Calcium secretion from the feline pancreas. Influence of hormonal and cholinergic secretagogues and of serum calcium.

    abstract::The influences of secretagogues and of elevated serum calcium concentrations on the calcium secretion from the cat pancreas have been studied in vivo. During a high and constant fluid secretion rate evoked by a background infusion of secretin, additional infusions of both cholecystokinin-pancreozymin and urecholine le...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198873

    authors: Layer P,Hotz J,Goebell H

    更新日期:1983-01-01 00:00:00

  • Plasmapheresis in Crohn's disease.

    abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198344

    authors: Holdstock GE,Fisher JA,Hamblin TJ,Loehry C

    更新日期:1979-01-01 00:00:00

  • What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.

    abstract:BACKGROUND/AIMS:Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000229773

    authors: Shiga H,Takagi S,Inoue R,Kinouchi Y,Ohkubo T,Takahashi S,Negoro K,Yokoyama H,Kato S,Fukushima K,Hiwatashi N,Shimosegawa T

    更新日期:2010-01-01 00:00:00

  • Fate of pancreatic enzymes in the human intestinal lumen in health and pancreatic insufficiency.

    abstract::The activities of pancreatic enzymes decrease during their passage from the duodenum to the terminal ileum, but degradation rates of individual enzymes are different. Whereas lipase activity is lost most rapidly, proteases and amylase are more stable. The mechanism by which lipase activity is destroyed is proteolysis,...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201097

    authors: Layer P,Gröger G

    更新日期:1993-01-01 00:00:00

  • Acute pancreatitis: when is enzyme treatment indicated?

    abstract::Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201102

    authors: McMahon MJ

    更新日期:1993-01-01 00:00:00

  • Huge hepatomegaly, jaundice and portal hypertension due to amyloidosis of the liver.

    abstract::A 3 years evolution with amyloid involvement, primarily of the liver, in a patient is described. This led to intrahepatic cholestasis and to portal hypertension with esophageal varices. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198459

    authors: Melkebeke P,Vandepitte J,Hannon R,Fevery J

    更新日期:1980-01-01 00:00:00

  • Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation.

    abstract::Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed rats. The middle third of the crypt was the area stimulated to contribute the ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198579

    authors: Deschner EE,Cohen BI,Raicht RF

    更新日期:1981-01-01 00:00:00