Abstract:
:Since biguanides are known to inhibit hexose and amino acid absorption in vivo and in vitro as well as vitamin B12 absorption the effect of phenethylbiguanide on taurocholate (TC) and water absorption was measured in rat ileum in vivo. Phenethylbiguanide exhibited a time-dependent inhibitory effect on TC- and water absorption. If the bile acid inhibitory effect of biguanides can be found in diabetics on treatment with biguanides it might explain the observed cholesterol-lowering effect of these oral antidiabetic drugs.
journal_name
Digestionjournal_title
Digestionauthors
Caspary WF,Lücke Hdoi
10.1159/000197672subject
Has Abstractpub_date
1975-01-01 00:00:00pages
179-82issue
3eissn
0012-2823issn
1421-9867journal_volume
12pub_type
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