Abstract:
:Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, and duodenum. Tachyphylaxis was seen in 6 out of 10 dogs. Motilin had no effect on isolated muscle strip preparations of the LES, fundus, antrum, and duodenum in this species.
journal_name
Digestionjournal_title
Digestionauthors
Jennewein HM,Hummelt H,Siewert R,Waldeck Fdoi
10.1159/000197714subject
Has Abstractpub_date
1975-01-01 00:00:00pages
246-50issue
4eissn
0012-2823issn
1421-9867journal_volume
13pub_type
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