The motor-stimulating effect of natural motilin on the lower esophageal sphincter fundus, antrum and duodenum in dogs.

Abstract:

:Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, and duodenum. Tachyphylaxis was seen in 6 out of 10 dogs. Motilin had no effect on isolated muscle strip preparations of the LES, fundus, antrum, and duodenum in this species.

journal_name

Digestion

journal_title

Digestion

authors

Jennewein HM,Hummelt H,Siewert R,Waldeck F

doi

10.1159/000197714

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

246-50

issue

4

eissn

0012-2823

issn

1421-9867

journal_volume

13

pub_type

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