Effect of intestinal diamine oxidase (DAO) depletion by heparin on mucosal polyamine metabolism.

Abstract:

:The aim of this study was to examine the relative importance of the enzymes ornithine decarboxylase (ODC) and diamine oxidase (DAO) in intestinal polyamine metabolism in normal rats. To study this we measured jejunal and ileal DAO and ODC activities and polyamine levels 2 h after injecting, in non-fasting male Wistar rats, either normal saline (controls) or a large dose of i.v. heparin to deplete intestinal mucosal DAO stores. We found that heparin significantly reduced mean DAO activity (p less than 0.001). As a result putrescine levels increased significantly in both jejunum (p less than 0.02) and ileum (p less than 0.01). Heparin-induced DAO depletion had no significant effect on spermine and spermidine levels at either site. The increased putrescine was associated with reduced ODC activity in both jejunum (p less than 0.01) and ileum (p less than 0.05). ODC activity correlated negatively with putrescine (p less than 0.001). These results suggest that (i) in normal rats, DAO is more important than ODC in regulating mucosal putrescine levels and (ii) putrescine exerts feedback inhibition of ODC.

journal_name

Digestion

journal_title

Digestion

authors

Rokkas T,Vaja S,Taylor P,Murphy GM,Dowling RH

doi

10.1159/000200411

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

378-82

eissn

0012-2823

issn

1421-9867

journal_volume

46 Suppl 2

pub_type

杂志文章
  • Prevention of relapse of reflux oesophagitis after endoscopic healing: the efficacy and safety of omeprazole compared with ranitidine.

    abstract::The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg ...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1159/000200522

    authors: Lundell L

    更新日期:1990-01-01 00:00:00

  • Adrenergic and cholinergic interactions in rat gastric somatostatin and gastrin release.

    abstract::The interactions of adrenergic and cholinergic influences on the gastric D cell were studied using an isolated perfused rat stomach in vitro. The sevenfold increase in the release of somatostatin-like immunoreactivity (SLI) in response to isoproterenol (4 . 10(-8) M) was dose-dependently inhibited by acetylcholine (10...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198817

    authors: Koop H,Behrens I,Bothe E,McIntosh CH,Pederson RA,Arnold R,Creutzfeldt W

    更新日期:1982-01-01 00:00:00

  • Trends in pre-liver transplant screening for cholangiocarcinoma among patients with primary sclerosing cholangitis.

    abstract:BACKGROUND:Cholangiocarcinoma (CCA) is the most common hepatobiliary malignancy complicating primary sclerosing cholangitis (PSC). Unfortunately, timely diagnosis of CCA in PSC patients remains challenging. AIM:To investigate the strategies among liver centers regarding pre-transplant screening for CCA in patients wit...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000357445

    authors: Trilianos P,Selaru F,Li Z,Gurakar A

    更新日期:2014-01-01 00:00:00

  • Mechanism of action of diphenolic laxatives: the role of adenylate cyclase and mucosal permeability.

    abstract::Net fluid movement and mucosal 14C-erythritol clearance were measured in ligated colonic loops of the rat in vivo. The diphenolic laxatives, oxyphenisatin and bisacodyl, dose-dependently inhibited net fluid absorption or caused secretion, both increased the 14C-erythritol clearance. Pretreatment with the adenylate cyc...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199105

    authors: Farack UM,Nell G

    更新日期:1984-01-01 00:00:00

  • Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer.

    abstract:BACKGROUND/AIMS:Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHOD...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000481346

    authors: Kitamura S,Muguruma N,Okamoto K,Tanahashi T,Fukuya A,Tanaka K,Fujimoto D,Kimura T,Miyamoto H,Bando Y,Takeuchi H,Shiba M,Takayama T

    更新日期:2017-11-01 00:00:00

  • Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer.

    abstract:BACKGROUND/AIMS:Adenosine deaminase (ADA)-deficient disease, a severe combined immunodeficiency, is most commonly associated with gastrointestinal disorders such as ulcer. The present study investigated the role of ADA in the pathogenesis of gastric ulcer. METHODS:ADA activity was measured in a variety of organs and t...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000252771

    authors: Yaguchi T,Saito M,Yasuda Y,Nishizaki T

    更新日期:2010-01-01 00:00:00

  • What is the maximal effective dose of caerulein in stimulating pancreatic secretion in man?

    abstract::The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199357

    authors: Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

    更新日期:1986-01-01 00:00:00

  • Analysis of gastroduodenitis and oesophagitis in relation to dyspeptic/reflux symptoms.

    abstract:BACKGROUND/AIMS:The pathogenesis of dyspeptic/reflux symptoms and the clinico-pathologic profile of affected patients are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007473

    authors: Villani L,Trespi E,Fiocca R,Broglia F,Colla C,Luinetti O,Tinelli C,Solcia E

    更新日期:1998-01-01 00:00:00

  • Acute pancreatitis: when is enzyme treatment indicated?

    abstract::Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201102

    authors: McMahon MJ

    更新日期:1993-01-01 00:00:00

  • A novel diamino-pyridine derivative prevents excessive leukocyte infiltration in aggravation of acute necrotizing pancreatitis.

    abstract::Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051452

    authors: Yamauchi J,Sunamura M,Shibuya K,Takeda K,Kobari M,Matsuno S

    更新日期:1999-01-01 00:00:00

  • Establishment and characterization of two new rectal neuroendocrine cell carcinoma cell lines.

    abstract:BACKGROUND:Human colorectal neuroendocrine cell carcinoma (NEC) is a rare disease with a poor prognosis. The biological behavior of NEC remains poorly understood. MATERIALS AND METHODS:We established two new NEC cell lines from a patient with rectal neuroendocrine carcinoma, NECS-P and NECS-L from the primary tumor an...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007825

    authors: Takahashi Y,Onda M,Tanaka N,Seya T

    更新日期:2000-01-01 00:00:00

  • Kinetics of anti-hepatitis C virus response during acute hepatitis in an immunosuppressed HCV chronically infected patient.

    abstract::A hepatitis C virus (HCV) chronically infected patient developed an episode of acute hepatitis during the course of immunosuppressive therapy given for a lymphoproliferative disease. It was noted that anti-HCV antibody response, seen to be relatively stable during the follow-up, lowered dramatically in coincidence wit...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200740

    authors: Sansonno D,Procaccio P,Dammacco F

    更新日期:1991-01-01 00:00:00

  • Therapy of viral hepatitis.

    abstract::Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000007532

    authors: Hoofnagle JH

    更新日期:1998-08-01 00:00:00

  • Level of intended sedation.

    abstract::Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient and the provider. The American Society of Anesthesiologists h...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000285504

    authors: Paspatis GA,Tribonias G,Paraskeva K

    更新日期:2010-01-01 00:00:00

  • Cutaneous electrical stimulation of acupuncture points may enhance gastric myoelectrical regularity.

    abstract:BACKGROUND/AIM:Cutaneous electrical stimulation has been reported to be as effective as electroacupuncture. The aim of this study was to test whether cutaneous electrical stimulation had the same effect as electroacupuncture to enhance the regularity of myoelectrical activity. METHODS:Fifteen healthy male volunteers w...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000065596

    authors: Chang CS,Chou JW,Ko CW,Wu CY,Chen GH

    更新日期:2002-01-01 00:00:00

  • Pain in the Early Phase of Pediatric Pancreatitis (PINEAPPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial.

    abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000441352

    authors: Zsoldos F,Párniczky A,Mosztbacher D,Tóth A,Lásztity N,Hegyi P,Hungarian Pancreatic Study Group and the International Association of Pancreatology.

    更新日期:2016-01-01 00:00:00

  • Efficacy of Full-Spectrum Endoscopy to Visualize the Major Duodenal Papilla in Patients with Familial Adenomatous Polyposis.

    abstract:BACKGROUND AND AIMS:Duodenal cancer is one of the extracolonic malignancies with known mortality in familial adenomatous polyposis (FAP) patients. Visualization of the major duodenal papilla (MDP) with a standard esophagogastroduodenoscopy (EGD) is currently insufficient because of the limited field of view. Full-spect...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000501476

    authors: Ichijima R,Abe S,Kobayashi S,Minagawa T,Tagawa T,Nakajima T,Yamada M,Takamaru H,Sekiguchi M,Sakamoto T,Oda I,Matsuda T,Saito Y,Gotoda T

    更新日期:2020-01-01 00:00:00

  • Transitional Care for Patients with Inflammatory Bowel Disease: Japanese Experience.

    abstract:BACKGROUND:Transition-related healthcare intervention has recently been receiving worldwide attention. Given the increasing incidence of pediatric inflammatory bowel disease (IBD) and its lifelong impact, transitional care has become an important issue. In Japan, guidelines to support the autonomy of IBD patients durin...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000510652

    authors: Kumagai H,Suzuki Y,Shimizu T

    更新日期:2021-01-01 00:00:00

  • Proctitis and proctosigmoiditis--a need to identify the extent of disease in epidemiological surveys.

    abstract::Proctitis and proctosigmoiditis may be distinct clinical entities. The lesions are restricted to the rectum or extend proximally to involve the sigmoid colon, respectively. Barium enema examination should be normal proximal to the rectum and sigmoid colon. Histology is used merely to confirm the disease process. We pr...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201013

    authors: Jayanthi V,Chuah SY,Probert CS,Mayberry M,Mayberry JF

    更新日期:1993-01-01 00:00:00

  • Nutrition in Inflammatory Bowel Disease.

    abstract:BACKGROUND:Westernization, above all associated changes in diet, has been postulated to be one of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn's disease and ulcerative colitis. SUMMARY:Diet represents a crucially important and intui...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000505368

    authors: Schreiner P,Martinho-Grueber M,Studerus D,Vavricka SR,Tilg H,Biedermann L,on behalf of Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology.

    更新日期:2020-01-01 00:00:00

  • Chronic Kidney Disease Elicits an Intestinal Inflammation Resulting in Intestinal Dysmotility Associated with the Activation of Inducible Nitric Oxide Synthesis in Rat.

    abstract::This study was conducted to investigate whether chronic kidney disease (CKD) affects intestinal inflammation and intestinal motility and the underlying mechanisms. Rats were randomized into control group and uremic group. Uremia rats were induced by the 5/6 kidney resection, while the control went through the same pro...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000481618

    authors: Yu C,Tan S,Wang Z,Deng B,Li J,Wang Q,Zhou C,Kang X,Yu Z,Zhuang S

    更新日期:2018-01-01 00:00:00

  • Clinical, controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract.

    abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199876

    authors: Coraggio F,Bertini G,Catalano A,Scarpato P,Gualdieri L

    更新日期:1989-01-01 00:00:00

  • Safety experience from long-term treatment with omeprazole.

    abstract::Omeprazole was administered for up to 6 years in 859 patients for 'prevention of relapse in patients with poorly responsive peptic ulcer or reflux oesophagitis'. The pattern of adverse events reported during long-term treatment was similar to the adverse-event profile in short-term treatment with omeprazole (n = 2,818...

    journal_title:Digestion

    pub_type: 杂志文章,meta分析

    doi:10.1159/000200922

    authors: Joelson S,Joelson IB,Lundborg P,Walan A,Wallander MA

    更新日期:1992-01-01 00:00:00

  • Dying in yoghurt: the number of living bacteria in probiotic yoghurt decreases under exposure to room temperature.

    abstract:BACKGROUND/AIMS:While probiotic bacteria are successfully used in the treatment of ulcerative colitis, the effect of commercially available probiotic products is still controversial. Here, we study whether the number of living probiotic bacteria in yoghurts is altered by an interruption of the cold chain. METHODS:Thre...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000308715

    authors: Scharl M,Geisel S,Vavricka SR,Rogler G

    更新日期:2011-01-01 00:00:00

  • Differential distribution of serotonin and tryptophan hydroxylase in the human gastrointestinal tract.

    abstract::The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007590

    authors: Meyer T,Brinck U

    更新日期:1999-01-01 00:00:00

  • Food restriction and recovery of nonabsorbed indicators from the small intestine of the rat.

    abstract::Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restric...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199576

    authors: Miller DL,Schedl HP,Bouska J,Phillips SF

    更新日期:1987-01-01 00:00:00

  • The cholecystokinin effect on human intestinal permeability: influence of chenodeoxycholic and ursodeoxycholic acid administration.

    abstract::The influence of CDCA and UDCA administration on human intestinal permeability to lactulose, as disclosed by intravenous CCK, has been investigated. For this purpose the fraction of lactulose excreted in the urine during 5 h after an oral load of the disaccharide in hypertonic solution was measured in 12 healthy subje...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198808

    authors: Budillon G,Parrilli G,Capuano G,Mazzacca G,Menzies IS

    更新日期:1982-01-01 00:00:00

  • Factors regulating prostaglandin uptake by rat small intestine.

    abstract::The uptake of prostaglandin E1 by rat intestine mucosal strips was investigated. The results indicate that: (1) PGE1 did not accumulate in the epithelial cells of rat intestine. The intracellular to extracellular distribution ratio did not reach unity in spite of the extended periods of incubation. (2) A decrease in t...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198774

    authors: Nassar CF,Haddad ME,Khuri RN

    更新日期:1982-01-01 00:00:00

  • Adrenergic effects on secretion of amylase from the rat salivary glands.

    abstract::The present study was undertaken to investigate the effect of adrenergic agents on secretion of amylase from the salivary glands in vivo. Saliva was collected from the distal oesophagus in conscious rats. Adrenaline increased the concentration of amylase in saliva and serum significantly. The result of infusion of alp...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199729

    authors: Skov Olsen P,Kirkegaard P,Rasmussen T,Magid E,Poulsen SS,Nexø E

    更新日期:1988-01-01 00:00:00

  • Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients.

    abstract:BACKGROUND/AIMS:There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patien...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000326854

    authors: Kim JH,Kim SY,Jung ES,Jung SW,Koo JS,Kim JH,Yeon JE,Kwon SY,Lee SW,Byun KS,Lee CH

    更新日期:2011-01-01 00:00:00