Safety experience from long-term treatment with omeprazole.

abstract：OBJECTIVE:The present study aimed to evaluate the micronucleus (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in the mitogen-stimulated lymphocytes of patients with ulcerative colitis (UC). In addition, we assessed MN frequency in exfoliated colonic epithelial cells obtained from both the diseased and heal...

journal_title：Digestion

authors： Karaman A,Hamurcu Z,Donmez H,Bitken N,Karaman H,Baskol M,Gursoy S,Guven K,Ozbakir O,Yucesoy M

更新日期：2012-01-01 00:00:00

abstract：:94 patients with peptic ulcerations of duodenum, stomach, and esophagus, who did not respond to 3 or more months high-dose (450 or 600 mg) treatment with ranitidine, were treated orally with 40 mg omeprazole daily. After healing all patients were offered long-term maintenance therapy with the same dose for 5 years. In...

journal_title：Digestion

authors： Brunner G,Creutzfeldt W,Harke U,Lamberts R

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND/AIMS:Pentoxifylline has many anti-inflammatory properties including inhibition of production of tumor necrosis factor alpha (TNF-alpha). Although pentoxifylline prevents several types of gastric mucosal injury, the effect of this drug on ulcer healing is unknown. In this study, we examined the effect of pent...

journal_title：Digestion

authors： Shimizu N,Watanabe T,Arakawa T,Fujiwara Y,Higuchi K,Kuroki T

更新日期：2000-01-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis represent distinct phenotypic forms of inflammatory bowel disease and continue to be a common cause of morbidity. The corticosteroids and the immunomodulatory drugs, which are the basis of treatment for the inflammatory bowel diseases, do not assure always satisfactory outcomes. ...

journal_title：Digestion

authors： Ioannidis O,Varnalidis I,Paraskevas G,Botsios D

更新日期：2011-01-01 00:00:00

abstract：:To assess the feasibility of a prospective incidence study of inflammatory bowel disease (IBD), the registration methods and incidence figures during 1990 were evaluated. The study was a collaboration between 14 hospitals in an area of close to one million inhabitants. Common diagnostic criteria for ulcerative colitis...

journal_title：Digestion

authors： Moum B,Vatn MH,Ekbom A,Fausa O,Aadland E,Lygren I,Sauar J,Schulz T

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Colonic diverticulosis is a common condition with obscure pathogenesis. Obesity, hyperlipidemia and hypertension have been demonstrated to increase the risk of complicated diverticular disease, but the impact of metabolic risk factors on the prevalence of uncomplicated diverticulosis has not been clearly d...

journal_title：Digestion

authors： Kopylov U,Ben-Horin S,Lahat A,Segev S,Avidan B,Carter D

更新日期：2012-01-01 00:00:00

abstract：:Lithium is a cation which has central nervous system effects and is able to interfere with both the release and action of polypeptide hormones. We examined its effect on basal and stimulated plasma gastrin and pancreatic polypeptide (PP) levels in 4 dogs with chronic gastric fistulas. Gastrin and PP release were stimu...

journal_title：Digestion

authors： Modlin IM,Ehrlich BE,Lamers CB,Diamond JM,Walsh JH

更新日期：1981-01-01 00:00:00

abstract：:Synthetic glucocorticoids, such as dexamethasone, and diets enriched with unsaturated fatty acids have been shown to stimulate hepatic bile salt synthesis. This fact led us to investigate the effects of dexamethasone and linoleic acid supplementation on bile secretion. Cholesterol (Ch) and phospholipid secretions are ...

journal_title：Digestion

authors： Domingo N,Debono E,Reynier MO,Crotte C,Thorin B,Charbonnier M,Clerc T,Grillasca J,Chanussot F,Lafont H

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:The gut-liver-axis presents the pathophysiological hallmark for multiple liver diseases and has been proposed to be modulated during stress and shock. Access to the gut-liver-axis needs crossing of the mucus and gut-vascular barrier. The role of β-adrenoreceptor-activation for both barriers has not been defi...

journal_title：Digestion

authors： Sorribas M,de Gottardi A,Moghadamrad S,Hassan M,Spadoni I,Rescigno M,Wiest R

更新日期：2020-01-01 00:00:00

abstract：:Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by ...

journal_title：Digestion

authors： Allan A,Jewell DP

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate whether the neuronal form of nitric oxide (NO) synthase (nNOS) in gastric mucosa differed from nNOS in the brain in subcellular distribution or antigenicity, and to determine the relative activity of the endothelial form of NO synthase (eNOS) and nNOS in gastric mucosa. METHODS:Subcellul...

journal_title：Digestion

authors： Price K,Hanson P

更新日期：1998-07-01 00:00:00

abstract：:A manometric study of the distal biliary tract was carried out by means of a side-hole perfused catheter passed through the papilla Vateri during duodenoscopy in patients with postcholecystectomy biliary pain not due to stones or inflammation of the biliary tree. The sphincter of Oddi showed in these cases a significa...

journal_title：Digestion

authors： Bortolotti M,Caletti GC,Brocchi E,Bersani G,Caletti T,Guizzardi G,Labò G

更新日期：1983-01-01 00:00:00

abstract：:Growth hormone-releasing factor (GRF) was reported to possess the growth-promoting action on the gastroduodenal mucosa that can be augmented by removal of endogenous somatostatin. Since mucosal proliferation was considered to contribute to healing of chronic gastroduodenal ulcerations, we designed the study to determi...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Dembinski A,Warzecha Z,Konturek PK,Yanaihara N

更新日期：1988-01-01 00:00:00

abstract：:High-fidelity simulation uses simulators that combine all of the physiological and pharmacological responses of a human in a manikin. These simulators change and respond to the users and trainees. Using simulators for teaching sedation in the field of gastroenterology unifies all the advantages of manikins. To underst...

journal_title：Digestion

authors： Hofmann N,Datz C,Schöchl H

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve (VN), modulates the immune system in the body. Recent studies of VN stimulation (VNS) in vivo systems have shown that it plays an anti-inflammatory role through CAIP. Inflammatory...

journal_title：Digestion

authors： Lei W,Duan Z

更新日期：2019-11-29 00:00:00

abstract：:A 3 years evolution with amyloid involvement, primarily of the liver, in a patient is described. This led to intrahepatic cholestasis and to portal hypertension with esophageal varices. ...

journal_title：Digestion

authors： Melkebeke P,Vandepitte J,Hannon R,Fevery J

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to analyze the endoscopic mucosal resection (EMR) with a novel uniquely shaped, double-loop snare (Dualoop, Medico's Hirata Inc., Tokyo, Japan) for colorectal polyps. METHODS:This was a clinical trial conducted in two referral centers, Kyoto Prefectural University of Medicine and Natio...

journal_title：Digestion

authors： Yoshida N,Saito Y,Hirose R,Ogiso K,Inada Y,Yagi N,Naito Y,Otake Y,Nakajima T,Matsuda T,Yanagisawa A,Itoh Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIM:True adenomas of the cardia appear to be extremely rare lesions. There are no data on the natural history and histopathological background of these lesions. We report 3 patients with true adenomas of the cardia. METHODS AND RESULTS:Three patients with polypoid masses at the cardia below the Z-line were ...

journal_title：Digestion

authors： Bajbouj M,von Weyhern C,Becker V,Seidl S,Ott R,Schatke W,Fend F,Schmid RM,Meining A

更新日期：2008-01-01 00:00:00

abstract：:2 cases of pancreatic disease in patients with malabsorption following small bowel radiation injury are reported. It is suggested that the pancreatic disease present in these patients occurred as a result of previous radiotherapy. ...

journal_title：Digestion

authors： Mitchell CJ,Simpson FG,Davison AM,Losowsky MS

更新日期：1979-01-01 00:00:00

abstract：:CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...

journal_title：Digestion

authors： Jaworek J,Konturek SJ

更新日期：1987-01-01 00:00:00

abstract：:8 children, known to have been hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive for more than 6 months and with chronic active hepatitis on biopsy, received 2.5 mg levamisole/kg/day, 2 days a week for 6-18 months. In 6 of the 8 children transaminases normalized within 4-18 months of thera...

journal_title：Digestion

authors： Fattovich G,Cadrobbi P,Crivellaro C,Pornaro E,Alberti A,Realdi G

更新日期：1982-01-01 00:00:00

abstract：:By immunohistochemistry and double staining technique, almost complete coexistence of galanin-like immunoreactivity (GAL-LI) and vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) was demonstrated in submucosal ganglionic cells and mucosal nerve fibers of the porcine ileum. The release of the two neurope...

journal_title：Digestion

authors： Harling H,Messell T,Poulsen SS,Rasmussen TN,Holst JJ

更新日期：1991-01-01 00:00:00

abstract：:Plasma lactate and urate concentrations, following 50 g oral fructose, were compared in 12 control subjects and 13 patients with liver disease. No serious adverse effects occurred following fructose ingestion, and in neither group did the plasma lactate concentration exceed 5.2 mmol/l. There were no significant differ...

journal_title：Digestion

authors： Douglas JG,Beckett GJ

更新日期：1982-01-01 00:00:00

abstract：:Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 pati...

journal_title：Digestion

authors： Imes S,Pinchbeck B,Dinwoodie A,Walker K,Thomson AB

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Grading gastric mucosal atrophy in antrum biopsy specimens remains a controversial subject because of limitations in interobserver agreement. We previously described a reliable, quantitative method for grading atrophy of the corpus mucosa with excellent reproducibility and good correlation with the Sydn...

journal_title：Digestion

authors： van Grieken NC,Meijer GA,Kale I,Bloemena E,Lindeman J,Offerhaus GJ,Meuwissen SG,Baak JP,Kuipers EJ

更新日期：2004-01-01 00:00:00

abstract：:The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust ...

journal_title：Digestion

authors： Vadgama P,Alberti KG

更新日期：1983-01-01 00:00:00

abstract：INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...

journal_title：Digestion

authors： Kudo T,Fujii T,Maisawa SI,Sasaki M,Uchida K,Ida S,Kagimoto S,Yoden A,Shimizu T

更新日期：2020-05-18 00:00:00

abstract：:Zinc nutriture has been studies in 30 patients with Crohn's disease using plasma zinc, hair zinc, and taste acuity as indices. Significant reductions in plasma zinc concentrations and taste acuity were seen in the patient groups as compared with normal controls. Hair zinc content was also generally low with several de...

journal_title：Digestion

authors： Solomons NW,Rosenberg IH,Sandstead HH,Vo-Khactu KP

更新日期：1977-01-01 00:00:00

abstract：:Outpatient treatment of haemorrhoids by elastic band ligation without anaesthetic was performed in 75 patients. Clinical review showed that 65 returned to work within 24 h of ligation, 8 in 48 h and 2 after 48 h. No patient required hospitalisation for either rectal bleeding or pain after ligation. In the first week a...

journal_title：Digestion

authors： Panda AP,Laughton JM,Elder JB,Gillespie IE

更新日期：1975-01-01 00:00:00

abstract：:Effects of indomethacin on healed partially healed gastric ulcers in the dog were studied. Gastric ulcers were produced by submucosal injection of 1 ml of 40% acetic acid solution into the bordering area of the fundus and antrum of the stomach. Indomethacin, 20 mg/kg, was given orally once daily for 5 days beginning o...

journal_title：Digestion

authors： Okabe S,Tabata K

更新日期：1981-01-01 00:00:00