The possible role of bicarbonate in mucosal protection and peptic ulceration.

Abstract:

:The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust mucus pH to a range at which this barrier property is optimized. It is further proposed that a high content of luminal bicarbonate will promote the transfer of protons across mucus by a buffer shuttle mechanism, and that this may be the basis for the development of peptic ulceration.

journal_name

Digestion

journal_title

Digestion

authors

Vadgama P,Alberti KG

doi

10.1159/000198954

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

203-13

issue

4

eissn

0012-2823

issn

1421-9867

journal_volume

27

pub_type

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