Abstract:
:The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust mucus pH to a range at which this barrier property is optimized. It is further proposed that a high content of luminal bicarbonate will promote the transfer of protons across mucus by a buffer shuttle mechanism, and that this may be the basis for the development of peptic ulceration.
journal_name
Digestionjournal_title
Digestionauthors
Vadgama P,Alberti KGdoi
10.1159/000198954subject
Has Abstractpub_date
1983-01-01 00:00:00pages
203-13issue
4eissn
0012-2823issn
1421-9867journal_volume
27pub_type
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