Importance of plasma aldosterone concentration on the natriuretic effect of spironolactone in patients with liver cirrhosis and ascites.

Abstract:

:23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly with plasma aldosterone concentration: r = 0.64; p less than 0.001. However, in cases with plasma albumin concentration less than 3 g/dl, glomerular filtration rate less than 80 ml/min, and plasma sodium concentration less than 136 mmol/l such a relationship was no longer significant. The diuretic response to spironolactone is mainly linked to plasma aldosterone concentration. Factors affecting the removal of ascites from the peritoneal cavity and renal sodium handling can influence the expected diuretic response to the drug.

journal_name

Digestion

journal_title

Digestion

authors

Bernardi M,Servadei D,Trevisani F,Rusticali AG,Gasbarrini G

doi

10.1159/000199198

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

189-93

issue

4

eissn

0012-2823

issn

1421-9867

journal_volume

31

pub_type

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