Abstract:
:23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly with plasma aldosterone concentration: r = 0.64; p less than 0.001. However, in cases with plasma albumin concentration less than 3 g/dl, glomerular filtration rate less than 80 ml/min, and plasma sodium concentration less than 136 mmol/l such a relationship was no longer significant. The diuretic response to spironolactone is mainly linked to plasma aldosterone concentration. Factors affecting the removal of ascites from the peritoneal cavity and renal sodium handling can influence the expected diuretic response to the drug.
journal_name
Digestionjournal_title
Digestionauthors
Bernardi M,Servadei D,Trevisani F,Rusticali AG,Gasbarrini Gdoi
10.1159/000199198subject
Has Abstractpub_date
1985-01-01 00:00:00pages
189-93issue
4eissn
0012-2823issn
1421-9867journal_volume
31pub_type
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