Abstract:
:The uptake of prostaglandin E1 by rat intestine mucosal strips was investigated. The results indicate that: (1) PGE1 did not accumulate in the epithelial cells of rat intestine. The intracellular to extracellular distribution ratio did not reach unity in spite of the extended periods of incubation. (2) A decrease in the sodium gradient across the brush-border membrane of intestinal cells significantly inhibited PGE1 uptake by the mucosal strips. (3) PGE1 uptake increases with increasing concentration of potassium in the incubation medium with a tendency for saturation at high K+ levels. (4) Calcium and magnesium ions had no effect on the steady-state uptake of PGE1 by the epithelial cells of rat intestine. (5) Addition of sodium carbonate or phosphate to the incubation medium significantly decreased PGE1 uptake by the intestinal cells. (6) Further studies of PGE1 uptake reveal a temperature-dependent process with a Q10 of 2.8.
journal_name
Digestionjournal_title
Digestionauthors
Nassar CF,Haddad ME,Khuri RNdoi
10.1159/000198774subject
Has Abstractpub_date
1982-01-01 00:00:00pages
47-53issue
1eissn
0012-2823issn
1421-9867journal_volume
24pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND AND AIM:Several studies performed in Western countries demonstrate the association between sleep dysfunction and gastroesophageal reflux disease (GERD), especially when nighttime heartburn is present. The purpose of this study was to examine the prevalence and risk factors of sleep dysfunction, and the effec...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000253849
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a functional bowel disorder which is characterized by abdominal pain and disturbed bowel habits. The pathophysiological mechanism is complex and still remains incompletely clear. Alterations at both the central and the peripheral level are thought to contribute to the sympto...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000165352
更新日期:2008-01-01 00:00:00
abstract:AIM:To determine the long-term effect of argon plasma coagulation (APC) of gastric inlet patches in the cervical esophagus for patients suffering from globus sensation. METHODS:We intended to follow up all patients between 2004 and 2011 (n = 49) who received argon plasma ablation of gastric inlet patches for globus se...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000355274
更新日期:2013-01-01 00:00:00
abstract::Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was ass...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200714
更新日期:1991-01-01 00:00:00
abstract::Since arginine can stimulate lymphocyte proliferation in the healthy human, its effect on lymphocyte proliferation in vitro was studied in 7 patients with far advanced gastric cancer. These patients with normal nourishment were ambulatory and could consume a regular diet. A daily dietary supplement of 30 g arginine fo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201023
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:While probiotic bacteria are successfully used in the treatment of ulcerative colitis, the effect of commercially available probiotic products is still controversial. Here, we study whether the number of living probiotic bacteria in yoghurts is altered by an interruption of the cold chain. METHODS:Thre...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000308715
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS:In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations we...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007634
更新日期:1999-03-01 00:00:00
abstract::Repeated intravenous injections of 2.0 clinical units (CU) secretin per kg body weight showed no effect on jejunal glucose absorption and net water movement in perfusion studies in vivo. The in vitro uptake of galactose and 3-O-methylglucose was not altered by a secretin load given 12 min before sacrifice. The values ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197730
更新日期:1975-01-01 00:00:00
abstract::Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199889
更新日期:1989-01-01 00:00:00
abstract::23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199198
更新日期:1985-01-01 00:00:00
abstract::A young woman with long-standing inflammatory bowel disease presented with a tender left gastrocnemius myositis in association with an exacerbation of her disease. Muscle biopsy showed a chronic inflammatory cell infiltrate and atrophic muscle fibres, but no granulomata or vasculitis, and her symptoms responded to hig...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199251
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Since resistance of Helicobacter pylori is developing very fast all over the world, new treatment regimens for eradication are urgently needed. AIM:To compare eradication success rate of H. pylori treatment regimens with and without doxycycline. METHODS:English medical literature searches were conducted fo...
journal_title:Digestion
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000443683
更新日期:2016-01-01 00:00:00
abstract::We consider the multiple interacting factors which lead to the proliferation of human gastric enterochromaffin-like (ECL) cells, and control of this proliferation by somatostatin and its analogues. Somatostatin receptors occur in human fundic mucosa, and octreotide can be considered a useful therapeutic tool to contro...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201386
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIMS:Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but als...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000484043
更新日期:2017-11-01 00:00:00
abstract::Lithium is a cation which has central nervous system effects and is able to interfere with both the release and action of polypeptide hormones. We examined its effect on basal and stimulated plasma gastrin and pancreatic polypeptide (PP) levels in 4 dogs with chronic gastric fistulas. Gastrin and PP release were stimu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198642
更新日期:1981-01-01 00:00:00
abstract::Malabsorption syndromes are commonly caused by pathological interferences of normal digestive processes. In the last several years major advances in the diagnosis and treatment of these syndromes has emerged. This review will focus on diseases in which the mucosal phase of the digestive process is predominately distur...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000100501
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Defective epithelial barrier has been implicated in the pathogenesis of irritable bowel syndrome (IBS) and inflammatory bowel diseases. The aim of this study was to investigate gut permeability in patients with inactive ulcerative colitis (UC) and in patients with IBS. METHODS:IBS patients of the diarr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000333083
更新日期:2012-01-01 00:00:00
abstract::The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000200231
更新日期:1990-01-01 00:00:00
abstract::Gastric actions of Nw-nitro-1-arginine methyl ester (L-NAME) were investigated in rats, as this agent is a reliable nitric oxide synthase inhibitor L-NAME solutions were placed in subcutaneous osmotic minipumps which continuously released L-NAME at 0.1, 1.0, 10, or 40 mg/kg/day. L-NAME dose and time-dependently enhanc...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201314
更新日期:1996-01-01 00:00:00
abstract::The treatment of malignant neuroendocrine gut and pancreatic tumors provides a therapeutic challenge. Surgery as well as medical treatment rarely cure the patient at this stage. Symptoms related to secretory products from the tumor might be life-threatening or at least reduce the quality of life considerably. Interfer...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201204
更新日期:1994-01-01 00:00:00
abstract::Mucosal intestinal cells migrate and differentiate simultaneously as they move out of the crypts to their functional site along the villus. Interactions between the enterocyte basal membrane domain and the extracellular intestinal basement membrane (IBM) have been suggested to be essential to both cell migration and d...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200363
更新日期:1990-01-01 00:00:00
abstract::The incidence of steatorrhea is said to be lower and its grade milder in Japanese because their fat intake is lower than that of Europeans and Americans. Failure to take this into account creates difficulties when attempting to compare data on pancreatic exocrine insufficiency in different countries. The authors exami...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051462
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000064935
更新日期:2002-01-01 00:00:00
abstract::The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199280
更新日期:1986-01-01 00:00:00
abstract::Recent progress in both basic and clinical research has led us to develop sophisticated and effective medical therapy of ulcerative colitis (UC). Although classical agents such as aminosalicylates, corticosteroids and immunomodulatory drugs have remained as the gold standard for decades, their novel formulations and/o...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000111486
更新日期:2008-01-01 00:00:00
abstract::The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg ...
journal_title:Digestion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000200522
更新日期:1990-01-01 00:00:00
abstract::Patients with moderate-to-severe disease and patients with steroid-refractory or steroid-dependent disease differ in their management, as the latter two groups usually involve patients whose condition is less acute. Systemic corticosteroids represent the mainstay of the management of moderate-to-severe disease and rem...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000111023
更新日期:2007-01-01 00:00:00
abstract::We conducted a retrospective analysis to evaluate the risk factors associated with the occurrence of acute hepatic failure following transcatheter arterial embolization (TAE) for hepatocellular carcinoma. From 1984 to 1993 we performed a total of 623 embolization procedures in 369 patients with both hepatocellular car...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201443
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051879
更新日期:2001-01-01 00:00:00
abstract::A 14C-triolein breath test was carried out on 49 subjects suffering from chronic pancreatitis or from other digestive diseases, and its results were compared with the daily fecal fat excretion. The 14CO2 peak excretion was abnormal in all the subjects with a fecal fat excretion above 14 g/day, whereas individual value...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199015
更新日期:1984-01-01 00:00:00