Abstract:
:The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 times/day). Animals received the diet regimen for 10 days from 1 day after induction of ulcer (day 0). Following the feeding regimens, serum gastrin levels, oxyntic gland mucosal DNA synthesis, and gastric secretory function were significantly lowered in the rats fed liquid diets. DNA synthesis in the duodenal mucosa was not different from the pre-ulcer levels. Pentagastrin significantly restored the DNA synthetic and gastric secretory activity of the liquid diet-fed rats toward the levels in the chow-fed group. In the latter group, a significant increase in DNA synthesis and levels of serum gastrin was found at day 6 (after 5 days feeding), which corresponded with a rapid, spontaneous healing of ulcers. Feeding rats liquid diet significantly delayed the healing of gastric, but not duodenal ulcers. Repeated administration of pentagastrin accelerated gastric ulcer healing in the liquid diet group toward the rate observed in the chow-fed group, but had no effect on the healing of duodenal ulcers. These results indicate that cell proliferation is an important factor in the healing of gastric ulcers.
journal_name
Digestionjournal_title
Digestionauthors
Takeuchi K,Johnson LRdoi
10.1159/000199280subject
Has Abstractpub_date
1986-01-01 00:00:00pages
92-100issue
2eissn
0012-2823issn
1421-9867journal_volume
33pub_type
杂志文章相关文献
DIGESTION文献大全abstract::In order to evaluate the mechanism behind the augmented postprandial gastric inhibitory polypeptide (GIP) release seen in patients with achlorhydria and hypergastrinemia, 8 healthy subjects were given a liquid test meal on three different days. On 1 day the meal was preceded by ranitidine (H2 receptor antagonist) to b...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198815
更新日期:1982-01-01 00:00:00
abstract::D-Galactosamine administration to rats (400 mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and 24 h after D-galactosamine injection. Plasma membrane 5'-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198373
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND AND AIM:Several studies performed in Western countries demonstrate the association between sleep dysfunction and gastroesophageal reflux disease (GERD), especially when nighttime heartburn is present. The purpose of this study was to examine the prevalence and risk factors of sleep dysfunction, and the effec...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000253849
更新日期:2010-01-01 00:00:00
abstract:AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051872
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed a self-completion method of ESD using Endosaber to eliminate the need for an additional device or human assistance during the procedure. The aim of this study was to evaluate the technical fe...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000502771
更新日期:2019-09-27 00:00:00
abstract::Proctitis and proctosigmoiditis may be distinct clinical entities. The lesions are restricted to the rectum or extend proximally to involve the sigmoid colon, respectively. Barium enema examination should be normal proximal to the rectum and sigmoid colon. Histology is used merely to confirm the disease process. We pr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201013
更新日期:1993-01-01 00:00:00
abstract:UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethano...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198824
更新日期:1982-01-01 00:00:00
abstract::Cell renewal in the duodenal mucosa of Mastomys was studied by autoradiography 1 and 24 h after intraperitoneal injection of tritiated thymidine. Non-specific duodenitis and duodenal ulceration were produced with a continuous infusion of histamine. Mucosal renewal in the duodenum of 30 control Mastomys was compared wi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200226
更新日期:1990-01-01 00:00:00
abstract::Combining the narrow-band imaging (NBI) system and magnifying endoscopy allows simple and clear visualization of microscopic structures of the superficial mucosa and its capillary patterns, which may be useful for precise endoscopic diagnosis in the gastrointestinal tract, being more closely to histopathological diagn...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000321799
更新日期:2011-01-01 00:00:00
abstract:AIM:To evaluate number and quality of publications in gastroenterology, hepatology and digestive endoscopy from Western Europe (Belgium, Denmark, France, Germany, Great Britain, Italy, the Netherlands, Spain, Sweden, Switzerland), Japan and USA over a recent 5-year period. METHODS:We screened by computer for full live...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007738
更新日期:2000-01-01 00:00:00
abstract::Diamine oxidase (DAO) is an enzyme located almost exclusively in the villus tip enterocytes of mammals. Its plasma activity, normally very low, is enhanced by intravenous heparin that releases the enzyme from the enterocytes into the blood. Postheparin plasma DAO (PHD) values have been shown to be significantly reduce...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199731
更新日期:1988-01-01 00:00:00
abstract::We consider the multiple interacting factors which lead to the proliferation of human gastric enterochromaffin-like (ECL) cells, and control of this proliferation by somatostatin and its analogues. Somatostatin receptors occur in human fundic mucosa, and octreotide can be considered a useful therapeutic tool to contro...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201386
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:Recently, several studies have demonstrated the usefulness of endoscopic submucosal dissection (ESD) for residual or locally recurrent colorectal lesions after endoscopic treatment. However, the feasibility of ESD for recurrent rectal lesions after transanal endoscopic microsurgery (TEM) has not been fully i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000505619
更新日期:2020-02-05 00:00:00
abstract::The form in which copper is bound in bile was studied in bile from patients with Wilson's disease, control subjects and rats. Bile was labelled with 64Cu. Sephadex column chromatography using gels G-200--G-10 showed a major 64Cu and protein peak of about 5,000 daltons and a minor peak of about 8,000 daltons. A high-mo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198027
更新日期:1977-01-01 00:00:00
abstract::The interactions of adrenergic and cholinergic influences on the gastric D cell were studied using an isolated perfused rat stomach in vitro. The sevenfold increase in the release of somatostatin-like immunoreactivity (SLI) in response to isoproterenol (4 . 10(-8) M) was dose-dependently inhibited by acetylcholine (10...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198817
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND/AIMS:Grading gastric mucosal atrophy in antrum biopsy specimens remains a controversial subject because of limitations in interobserver agreement. We previously described a reliable, quantitative method for grading atrophy of the corpus mucosa with excellent reproducibility and good correlation with the Sydn...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076544
更新日期:2004-01-01 00:00:00
abstract::We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198753
更新日期:1982-01-01 00:00:00
abstract::Since arginine can stimulate lymphocyte proliferation in the healthy human, its effect on lymphocyte proliferation in vitro was studied in 7 patients with far advanced gastric cancer. These patients with normal nourishment were ambulatory and could consume a regular diet. A daily dietary supplement of 30 g arginine fo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201023
更新日期:1993-01-01 00:00:00
abstract::In order to study some of the molecular events during the hepatic passage of gastrin, we perfused sulfated natural porcine gastrin (G17 II) through isolated pig livers. The disappearance half time of G17 II was about 20-30 min when the starting gastrin concentrations were greater than 100 pM; lower concentrations were...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199029
更新日期:1984-01-01 00:00:00
abstract::Activation of enzyme phospholipase A2 (EC 3.1.1.4), the major liberator of arachidonic acid, has been proposed as a component in the pathogenesis of inflammatory bowel disease. To test the hypothesis that phospholipase A2 activity is increased in ulcerative colitis, enzyme activity was investigated in colonic biopsies...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200753
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy for advanced gastric cancer is expected to improve prognoses. However, as there is no method to evaluate neoadjuvant chemotherapeutic efficacy before gastrectomy, some patients at high risk for a poor prognosis undergo gastrectomy. The aim of the present study was to investigate whet...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000500907
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea in infancy. A variant with onset in adulthood has recently been described. The immune mechanisms underlying AIE are unclear and the experience in the management of adult AIE is very limited. CASE REPORT:A 19-year-old male patient with ma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000084648
更新日期:2005-01-01 00:00:00
abstract::Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restric...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199576
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIMS:In patients with active ulcerative colitis (UC), pharmacologics, although initially effective in most patients, are associated with refractoriness, loss of response or unfavourable side effects as additional morbidity factors. Depletion of myeloid lineage leucocytes like the CD14(+)CD16(+) monocyte phen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000479502
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000485179
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to compare the accuracy of magnifying endoscopy with narrow band imaging for the diagnosis of depth of invasion by Japan Esophageal Society (JES) classification and inter- and intraobserver agreement of JES intrapapillary capillary loop (IPCL) classification. METHODS:It was a r...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000489490
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate whether the neuronal form of nitric oxide (NO) synthase (nNOS) in gastric mucosa differed from nNOS in the brain in subcellular distribution or antigenicity, and to determine the relative activity of the endothelial form of NO synthase (eNOS) and nNOS in gastric mucosa. METHODS:Subcellul...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007507
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND AND AIM:Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000495749
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000511589
更新日期:2020-11-18 00:00:00
abstract::By immunohistochemistry and double staining technique, almost complete coexistence of galanin-like immunoreactivity (GAL-LI) and vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) was demonstrated in submucosal ganglionic cells and mucosal nerve fibers of the porcine ileum. The release of the two neurope...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200741
更新日期:1991-01-01 00:00:00