Plaunotol stimulates endogenous secretin release and exocrine pancreatic secretion in rats.

Abstract:

:The effect of the new antiulcer agent plaunotol on the release of endogenous secretin and the pancreatic exocrine secretion was investigated in anesthetized rats. In 48 rats with pancreatic and biliary diversion, continuous intraduodenal infusion of plaunotol in 3 graded doses (5, 20 and 80 mg/h/rat) resulted in significant increases in both circulating plasma secretin concentration and pancreatic exocrine secretion, including volume and bicarbonate output, in a dose-dependent manner (r = 0.655, p less than 0.001; r = 0.598, p less than 0.001; r = 0.436, p less than 0.01, respectively). The pancreatic bicarbonate output was closely correlated to plasma secretin concentrations (r = 0.631, p less than 0.001). Amylase output also increased after plaunotol administration, but not in a dose-dependent manner (r = 0.092, n.s.). These findings suggest strongly that the increase in pancreatic secretion of fluid and bicarbonate output was mainly due to increased endogenous secretin release resulting from plaunotol administration.

journal_name

Digestion

journal_title

Digestion

authors

Chang JH,Watanabe S,Shiratori K,Moriyoshi Y,Takeuchi T

doi

10.1159/000199903

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

142-7

issue

3

eissn

0012-2823

issn

1421-9867

journal_volume

44

pub_type

杂志文章
  • No impairment of antipyrine elimination by the selective anticholinergic drug pirenzepine.

    abstract::The elimination kinetics of antipyrine have been established under basal environmental conditions in 6 healthy volunteers. Concentrations of antipyrine in serum were measured by a relatively fast high-pressure liquid chromatography method using a radial-compression chromatographic system. Pretreatment of the subjects ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198918

    authors: Paxton JW,Foote SE,Paton DM

    更新日期:1983-01-01 00:00:00

  • Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma.

    abstract:BACKGROUND/AIMS:Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydras...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000297208

    authors: Kato Y,Yashiro M,Noda S,Kashiwagi S,Matsuoka J,Fuyuhiro Y,Doi Y,Hirakawa K

    更新日期:2010-01-01 00:00:00

  • A new simple immunoassay for detecting Helicobacter pylori infection: antigen in stool specimens.

    abstract:BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007691

    authors: Fanti L,Mezzi G,Cavallero A,Gesu G,Bonato C,Masci E

    更新日期:1999-09-01 00:00:00

  • The effect of L-amino acids given intravenously on gastric secretion stimulated by pentagastrin in dogs.

    abstract::L-Amino acid solution given intravenously in Heidenhain pouch dogs resulted in marked changes of both basal and pentagastrin-stimulated gastric secretions. During a 1-hour amino acid infusion, a significant augmentation of pentagastrin-induced secretion was observed. A significant increase of secretion during amino ac...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198207

    authors: Bilski R,Kowalewski K,Secord DC

    更新日期:1978-01-01 00:00:00

  • Chromoendoscopy is a valuable tool for screening of high-risk patients with head and neck cancer for early detection of esophageal cancer.

    abstract:BACKGROUND:The incidence of esophageal cancer is markedly increased in patients with head and neck cancer, and the presence of esophageal cancer is associated with reduced survival rates. AIMS:We investigated whether the results of screening for esophageal cancer in patients with head and neck cancer using chromoendos...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000094523

    authors: Moschler O,Spahn TW,Middelberg-Bisping C,Grosse-Thie W,Christoph B,Kloeppel G,Mueller MK

    更新日期:2006-01-01 00:00:00

  • Effect of secretin and caerulein on the absorption of water, electrolytes and glucose from the jejunum of dogs.

    abstract::The effects of secretin and caerulein on the absorption of water, sodium, potassium and glucose from the jejunum of dogs were investigated. Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period. Adding an intravenous ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199369

    authors: Hirose S,Shimazaki K,Hattori N

    更新日期:1986-01-01 00:00:00

  • Endoscopic Submucosal Dissection Using EndoTrac, a Novel Traction Device.

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) is recognized as a minimally invasive and curative treatment for superficial gastrointestinal (GI) cancers. However, ESD is still challenging and time-consuming with a high risk of adverse events such as bleeding and perforation. Various traction methods have been explo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000511731

    authors: Kaku H,Toyonaga T,Tanaka S,Takihara H,Baba S,Tsubouchi E,Ikeda Y,Orita H,Nakamoto M,Horikawa Y,Chiba H,Ban H,Furumoto Y,Morita R,Kodama Y

    更新日期:2020-12-22 00:00:00

  • Failure of a prolyl 4-hydroxylase inhibitor to alter extracellular matrix deposition during experimental pancreatitis.

    abstract::In chronic pancreatitis the exocrine pancreatic tissue is replaced by extracellular matrix deposits from fibroblasts. We have stimulated fibrogenesis in the pancreas by inducing a single episode of cerulein pancreatitis (10 microg/kg/h for 12 h). We have used a spectrophotometrical assay to measure the tissue hydroxyp...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201423

    authors: Weidenbach H,Lerch MM,Turi S,Bachem M,Adler G

    更新日期:1997-01-01 00:00:00

  • Capnographic monitoring during endoscopic submucosal dissection with patients under deep sedation: a prospective, crossover trial of air and carbon dioxide insufflations.

    abstract:BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000328694

    authors: Takano A,Kobayashi M,Takeuchi M,Hashimoto S,Mizuno K,Narisawa R,Aoyagi Y

    更新日期:2011-01-01 00:00:00

  • Chest Pain after Endoscopic Submucosal Dissection for Esophageal Cancer: The Simple and Clinically Useful Surrogate Marker for Transmural Thermal Injury by Electrocoagulation.

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000510353

    authors: Sakai M,Sohda M,Saito H,Ubukata Y,Nakazawa N,Kuriyama K,Hara K,Sano A,Ogata K,Yokobori T,Kuwano H,Shirabe K,Saeki H

    更新日期:2020-10-08 00:00:00

  • Scientific publications in gastroenterology and hepatology in Western Europe, USA and Japan in the years 1992-1996: a global survey.

    abstract:AIM:To evaluate number and quality of publications in gastroenterology, hepatology and digestive endoscopy from Western Europe (Belgium, Denmark, France, Germany, Great Britain, Italy, the Netherlands, Spain, Sweden, Switzerland), Japan and USA over a recent 5-year period. METHODS:We screened by computer for full live...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007738

    authors: Sorrentino D,De Biase F,Trevisi A,Bartoli E

    更新日期:2000-01-01 00:00:00

  • Effects of the soluble fibre pectin on intestinal cell proliferation, fecal short chain fatty acid production and microbial population.

    abstract:AIM:Although pectin, a dietary fibre, has been suggested to possess some trophic effects on the intestine, the mechanisms involved remain unclear. This study aimed to evaluate the effects of pectin on rat intestinal cell proliferation and the intraluminal environment. METHODS:Control and pectin-fed rats were given a f...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000069705

    authors: Fukunaga T,Sasaki M,Araki Y,Okamoto T,Yasuoka T,Tsujikawa T,Fujiyama Y,Bamba T

    更新日期:2003-01-01 00:00:00

  • Cytoprotection of canine gastric mucosa by prostacyclin: possible mediation by increased mucosal blood flow.

    abstract:UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethano...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198824

    authors: Konturek SJ,Robert A

    更新日期:1982-01-01 00:00:00

  • Effect of the somatostatin analogue sandostatin (SMS 201-995) on gastrointestinal, pancreatic and biliary function and hormone release in normal men.

    abstract::The effect of the long-acting somatostatin analogue Sandostatin (SMS 201-995) on intestinal absorption and propagation (mouth-to-caecum transit time; MCTT), on pancreatic secretion and on gall bladder contraction after direct (secretin-pancreozymin test) and indirect stimulation (Lundh meal), and on meal-induced respo...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199408

    authors: Lembcke B,Creutzfeldt W,Schleser S,Ebert R,Shaw C,Koop I

    更新日期:1987-01-01 00:00:00

  • Value of prealbumin plasma levels as liver test.

    abstract::To assess the sensitivity, specificity and clinical value of prealbumin as liver test, prealbumin plasma levels were measured in 100 patients with liver disease and in 65 patients without clinical evidence of liver impairment. The sensitivity of prealbuminemia was higher than that of albumin, pseudocholinesterase, apo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199471

    authors: Rondana M,Milani L,Merkel C,Caregaro L,Gatta A

    更新日期:1987-01-01 00:00:00

  • Inhibition of bile acid and water absorption by phenethylbiguanide in rat ileum in vivo.

    abstract::Since biguanides are known to inhibit hexose and amino acid absorption in vivo and in vitro as well as vitamin B12 absorption the effect of phenethylbiguanide on taurocholate (TC) and water absorption was measured in rat ileum in vivo. Phenethylbiguanide exhibited a time-dependent inhibitory effect on TC- and water ab...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197672

    authors: Caspary WF,Lücke H

    更新日期:1975-01-01 00:00:00

  • Metal absorption and the intestinal mucus layer.

    abstract::The luminal mucus layer of the rat's small intestine was separated from the mucosa by filling the lumen with agar jelly. When the rats were fasted overnight and given 59Fe or 65Zn by stomach tube the mucus isolated by this technique contained more isotope and more sialic acid than fed controls, and more of the isotope...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199480

    authors: Quarterman J

    更新日期:1987-01-01 00:00:00

  • Effect of low dosage of interferon on natural killer activity in patients with HBsAg-positive chronic active hepatitis.

    abstract::The effect of human leukocyte interferon (IFN) on natural killer (NK) activity in 7 patients with HBsAg-positive chronic active hepatitis was investigated. Human leukocyte IFN was intramuscularly given once a week for 4 consecutive weeks (10 X 10(5), 5 X 10(5), 2 X 10(5) and 1 X 10(5) U). 1 week after the initial inje...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199107

    authors: Matsumura N,Yoshikawa T,Kondo M,Imanishi J,Kishida T

    更新日期:1984-01-01 00:00:00

  • Polyamines and the recovery of intestinal morphology and function after ischemic damage in rats.

    abstract::We have followed the time-course of the morphological and functional recovery of intestinal mucosa after 90 min of mesenteric vascular occlusion. At the end of the ischemic period the villi were smashed, but crypts were preserved. Microvillous hydrolase activities showed a dramatic drop when compared with sham-operate...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201143

    authors: Kummerlen C,Seiler N,Galluser M,Gossé F,Knodgen B,Hasselmann M,Raul F

    更新日期:1994-01-01 00:00:00

  • Changes in bacterial phagocytosis of macrophages in experimental ulcerative colitis.

    abstract::We previously reported that numerous macrophages which phagocytosed dextran sulfate sodium were observed to have accumulated in the mucosal lesions and in the spleen in experimental ulcerative colitis induced in mice with dextran sulfate sodium. In this paper, we investigated the bacterial phagocytic ability of macrop...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201236

    authors: Ohkusa T,Okayasu I,Tokoi S,Araki A,Ozaki Y

    更新日期:1995-01-01 00:00:00

  • Influence of short- and long-term feeding of an alpha-amylase inhibitor (BAY e 4609) on the exocrine pancreas of the rat.

    abstract::The effect of feeding an alpha-amylase inhibitor (BAY e 4609, 700 mg/100 g food) for 20 or 90 days on the enzymes of the exocrine pancreas of the rat was investigated. The amylase inhibitor-fed rats gained significantly less weight despite a higher food intake than control rats on a standard diet. Fecal weight increas...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198545

    authors: Fölsch UR,Grieb N,Caspary WF,Creutzfeldt W

    更新日期:1981-01-01 00:00:00

  • Impact of histopathology on the outcome of D1/D2 gastrectomies with R0 resection.

    abstract:AIMS:The primary objective of this study was to clarify the influence of histotype on the outcome of D1/D2 gastrectomized patients with pathologically proven R0 resection. The secondary objective was to demonstrate overall survival (OS), disease-free survival (DFS), and locoregional recurrence rates following standard ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338298

    authors: Uslu A,Bati H,Postaci H,Nart A,Eliyatkin N,Yetis H,Corumlu B,Aykas A,Zengel B

    更新日期:2012-01-01 00:00:00

  • Vitamin A status in 137 patients with Crohn's disease.

    abstract::Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 pati...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199495

    authors: Imes S,Pinchbeck B,Dinwoodie A,Walker K,Thomson AB

    更新日期:1987-01-01 00:00:00

  • Validity of a novel biopsy urease test (HUT) and a simplified 13C-urea breath test for diagnosis of Helicobacter pylori infection and estimation of the severity of gastritis.

    abstract::This prospective study was designed to validate a novel biopsy urease test as well as a simplified 13C-urea breath test for the detection of Helicobacter pylori. In addition, the hypothesis was tested that both the reaction velocity of the urease test and the 13CO2 excess of the urea breath test may allow a prediction...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201366

    authors: Labenz J,Bärsch G,Peitz U,Aygen S,Hennemann O,Tillenburg B,Becker T,Stolte M

    更新日期:1996-11-01 00:00:00

  • Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Since resistance of Helicobacter pylori is developing very fast all over the world, new treatment regimens for eradication are urgently needed. AIM:To compare eradication success rate of H. pylori treatment regimens with and without doxycycline. METHODS:English medical literature searches were conducted fo...

    journal_title:Digestion

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000443683

    authors: Niv Y

    更新日期:2016-01-01 00:00:00

  • Transplantation of adenomatous polyps, normal colonic mucosa and adenocarcinoma of colon into athymic mice.

    abstract::Fragments of benign colonic adenomatous polyps of man, adenocarcinoma of the colon of man, and normal colonic mucosa of man and rodent were transplanted under the kidney capsule of athymic mice. Benign human adenomatous cells survived for periods of up to 28 days, normal rodent colonic epithelial cells for 45 days and...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198567

    authors: Bhargava DK,Lipkin M

    更新日期:1981-01-01 00:00:00

  • Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.

    abstract:BACKGROUND/AIM:Studies have demonstrated an important role for endogenous PG and NO in the healing of chronic gastric ulcers. We investigated the effects of COX and NOS inhibitors on the healing of duodenal ulcers, in comparison with gastric ulcers, in rats. METHODS:Gastric and duodenal ulcers were induced by serosal ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000066759

    authors: Araki H,Komoike Y,Matsumoto M,Tanaka A,Takeuchi K

    更新日期:2002-01-01 00:00:00

  • Effects of pirenzepine and atropine on amylase response to various secretagogues from the rat pancreatic acini.

    abstract::CCK-8, bombesin, secretin and urecholine added in various concentrations to the incubation medium of the dispersed pancreatic acini, obtained from rats, resulted in a dose-dependent stimulation of amylase secretion, the half-maximal response being achieved at 3 X 10(-12), 10(-10), 10(-7) and 10(-5) M, respectively. Pi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199415

    authors: Jaworek J,Konturek SJ

    更新日期:1987-01-01 00:00:00

  • Open-access upper gastrointestinal endoscopy a decade after the introduction of proton pump inhibitors and helicobacter pylori eradication: a shift in endoscopic findings.

    abstract:BACKGROUND/AIM:Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000110684

    authors: van Kerkhoven LA,van Rijswijck SJ,van Rossum LG,Laheij RJ,Witteman EM,Tan AC,Jansen JB

    更新日期:2007-01-01 00:00:00

  • Effect of food intake on circulating antigen-antibody complexes in patients with alcoholic liver cirrhosis.

    abstract::Serum antibodies directed against 5 alimentary antigens and antigen-antibody complexes were determined in 15 control subjects and in 15 patients with alcoholic liver cirrhosis. Cirrhotic patients presented an increased immune response against these antigens. Antigen-antibody complexes were detected in the fasting plas...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198162

    authors: André F,Druguet M,André C

    更新日期:1978-01-01 00:00:00