Abstract:
:Fragments of benign colonic adenomatous polyps of man, adenocarcinoma of the colon of man, and normal colonic mucosa of man and rodent were transplanted under the kidney capsule of athymic mice. Benign human adenomatous cells survived for periods of up to 28 days, normal rodent colonic epithelial cells for 45 days and colonic carcinoma cells for 43 days. This was demonstrated by morphologic criteria, and by the incorporation of tritiated thymidine into DNA of the epithelial cells. The transplantation technique can supplement organ culture methods for the maintenance of adenomatous tissue derived from human colonic mucosa, in order to facilitate studies of growth characteristics and transformation of the cells.
journal_name
Digestionjournal_title
Digestionauthors
Bhargava DK,Lipkin Mdoi
10.1159/000198567subject
Has Abstractpub_date
1981-01-01 00:00:00pages
225-31issue
5eissn
0012-2823issn
1421-9867journal_volume
21pub_type
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