No impairment of antipyrine elimination by the selective anticholinergic drug pirenzepine.

Abstract:

:The elimination kinetics of antipyrine have been established under basal environmental conditions in 6 healthy volunteers. Concentrations of antipyrine in serum were measured by a relatively fast high-pressure liquid chromatography method using a radial-compression chromatographic system. Pretreatment of the subjects with therapeutic doses of pirenzepine over 5 days had no significant effect on the absorption, distribution, and elimination of antipyrine. These results suggest that pirenzepine is free of the inhibition of the hepatic mixed function oxidase system produced by cimetidine.

journal_name

Digestion

journal_title

Digestion

authors

Paxton JW,Foote SE,Paton DM

doi

10.1159/000198918

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

44-6

issue

1

eissn

0012-2823

issn

1421-9867

journal_volume

27

pub_type

杂志文章
  • Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related chronic gastritis.

    abstract::Combining the narrow-band imaging (NBI) system and magnifying endoscopy allows simple and clear visualization of microscopic structures of the superficial mucosa and its capillary patterns, which may be useful for precise endoscopic diagnosis in the gastrointestinal tract, being more closely to histopathological diagn...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000321799

    authors: Okubo M,Tahara T,Shibata T,Nakamura M,Kamiya Y,Yoshioka D,Maeda Y,Yonemura J,Ishizuka T,Arisawa T,Hirata I

    更新日期:2011-01-01 00:00:00

  • Acute hepatic failure following transcatheter arterial embolization for the treatment of hepatocellular carcinoma.

    abstract::We conducted a retrospective analysis to evaluate the risk factors associated with the occurrence of acute hepatic failure following transcatheter arterial embolization (TAE) for hepatocellular carcinoma. From 1984 to 1993 we performed a total of 623 embolization procedures in 369 patients with both hepatocellular car...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201443

    authors: Katsushima S,Inokuma T,Oi H,Okamura J,Higashi T,Takeuchi R,Hidaka A,Shigeno C,Iida Y,Konishi J

    更新日期:1997-01-01 00:00:00

  • Chemiluminescence by polymorphonuclear leucocyte subpopulations in chronic inflammatory bowel disease. Influence of the cell separation procedure.

    abstract::Chemiluminescence (CL) is a simple quantitative assay of polymorphonuclear leucocyte (PMNL) oxidative metabolism. PMNL CL was found to be significantly higher in patients with chronic inflammatory bowel disease than in normal controls (167 +/- 60 vs. 139 +/- 50 mV/10(5) cells, p less than 0.05). There were no signific...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200238

    authors: Kelleher D,Feighery C,Weir DG

    更新日期:1990-01-01 00:00:00

  • Characterization of the gastroprotective effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine hydrochloride, a non-H1/non-H2 histamine antagonist.

    abstract::N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200489

    authors: Glavin GB,Gerrard JM

    更新日期:1990-01-01 00:00:00

  • A critical assessment of the current status of non-erosive reflux disease.

    abstract::Non-erosive reflux disease (NERD) has assumed increasing prominence in studies of gastroesophageal reflux disease (GERD), but it remains a challenge to define NERD precisely and to define its place in the investigation and treatment of GERD. Most simply, NERD may be defined as GERD in an individual who has no evidence...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000151255

    authors: Armstrong D

    更新日期:2008-01-01 00:00:00

  • Induction of gastric ornithine decarboxylase in early weaning rats.

    abstract:BACKGROUND/AIMS:Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach. METHODS:Suckling rats were prematurely weaned on postnatal day 15 and followed through...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051892

    authors: Lin CH,Lyons H,Seelbach MS,Tolia V,Vijesurier R

    更新日期:2001-01-01 00:00:00

  • Gastrocnemius myositis in a patient with inflammatory bowel disease.

    abstract::A young woman with long-standing inflammatory bowel disease presented with a tender left gastrocnemius myositis in association with an exacerbation of her disease. Muscle biopsy showed a chronic inflammatory cell infiltrate and atrophic muscle fibres, but no granulomata or vasculitis, and her symptoms responded to hig...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199251

    authors: Hall MJ,Thomas WE,Cooper BT

    更新日期:1985-01-01 00:00:00

  • Life events and daily stress in duodenal ulcer disease. A prospective study of patients with active disease and in remission.

    abstract::Life events and daily stress were assessed in patients with duodenal ulcer, active or in remission, and in matched disease and normal controls. The mean positive life event scores were significantly lower in duodenal ulcer patients than in disease and healthy controls, and lower in patients with active ulcer than in t...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200949

    authors: Hui WM,Shiu LP,Lok AS,Lam SK

    更新日期:1992-01-01 00:00:00

  • The motor-stimulating effect of natural motilin on the lower esophageal sphincter fundus, antrum and duodenum in dogs.

    abstract::Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, a...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197714

    authors: Jennewein HM,Hummelt H,Siewert R,Waldeck F

    更新日期:1975-01-01 00:00:00

  • HLA in different forms of chronic active hepatitis. A comparison between adult patients and children.

    abstract::108 adult patients and 34 children with chronic active hepatitis (CAH) are divided in four groups on the basis of presence and absence of hepatitis B surface antigen (HBsAg) and autoantibodies (AutoAb). There are significant differences in the numeric distribution among the four groups and the sex distribution between...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198011

    authors: Freudenberg J,Baumann H,Arnold W,Berger J,Büschenfelde KH

    更新日期:1977-01-01 00:00:00

  • Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups.

    abstract:BACKGROUND/AIMS:This study aimed at (i) clarifying the factors associated with high scores on the modified frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) among 3,505 relatively healthy subjects undergoing routine medical health checkups with gastrointestinal endoscopy and (ii) comparing risk...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000445713

    authors: Takeshita E,Sakata Y,Hara M,Akutagawa K,Sakata N,Endo H,Ohyama T,Matsunaga K,Yoshioka T,Kawakubo H,Tanaka Y,Shirai S,Ito Y,Tsuruoka N,Iwakiri R,Kusano M,Fujimoto K

    更新日期:2016-01-01 00:00:00

  • The utility of cellulose meals for studies on gastrointestinal motility in dogs.

    abstract::This study evaluated the effect of a cellulose meal and a cellulose-oleic acid meal on gastroduodenal motility and gastric emptying. The cellulose meal produced a high antral motility index (100 +/- 34 V/10 min) and a high proportion (80.2%) of propulsive duodenal contractions. The oleic acid meal was associated with ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198829

    authors: Schemann M,Ehrlein HJ

    更新日期:1982-01-01 00:00:00

  • Impact of histopathology on the outcome of D1/D2 gastrectomies with R0 resection.

    abstract:AIMS:The primary objective of this study was to clarify the influence of histotype on the outcome of D1/D2 gastrectomized patients with pathologically proven R0 resection. The secondary objective was to demonstrate overall survival (OS), disease-free survival (DFS), and locoregional recurrence rates following standard ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338298

    authors: Uslu A,Bati H,Postaci H,Nart A,Eliyatkin N,Yetis H,Corumlu B,Aykas A,Zengel B

    更新日期:2012-01-01 00:00:00

  • Obesity, metabolic syndrome and the risk of development of colonic diverticulosis.

    abstract:INTRODUCTION:Colonic diverticulosis is a common condition with obscure pathogenesis. Obesity, hyperlipidemia and hypertension have been demonstrated to increase the risk of complicated diverticular disease, but the impact of metabolic risk factors on the prevalence of uncomplicated diverticulosis has not been clearly d...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000339881

    authors: Kopylov U,Ben-Horin S,Lahat A,Segev S,Avidan B,Carter D

    更新日期:2012-01-01 00:00:00

  • Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome.

    abstract:BACKGROUND AND AIMS:Validity of the lactulose breath test (LBT) to diagnose small intestinal bacterial overgrowth (SIBO) has been questioned. Therefore, a study was planned to compare LBT with glucose breath test (GBT) to diagnose SIBO in irritable bowel syndrome (IBS) patients and controls. METHODS:175 diarrhea-predo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000336174

    authors: Rana SV,Sharma S,Kaur J,Sinha SK,Singh K

    更新日期:2012-01-01 00:00:00

  • The importance of disease prevalence in assessing the diagnostic value of a test: endoscopic markers in celiac disease.

    abstract:BACKGROUND/AIMS:We evaluated the diagnostic variability and reproducibility of endoscopic signs in two populations with a different pretest likelihood of celiac disease (CD). METHODS:We recruited 289 CD patients (both adults and children) in a multicenter prospective study. Group 1 (high risk) included 111 patients re...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000350436

    authors: Pellegrino S,Furfaro F,Tortora A,Naso P,D'Agate C,Spina M,Belluardo N,Bertone A,Passanisi G,Malandrino S,Familiari L,Villanacci V,Puzzo L,Tuccari G,Sciacca A,Vieni G,Costa S,Currò G,Magazzù G,Sferlazzas C,Bassotti

    更新日期:2013-01-01 00:00:00

  • Clinical, controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract.

    abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199876

    authors: Coraggio F,Bertini G,Catalano A,Scarpato P,Gualdieri L

    更新日期:1989-01-01 00:00:00

  • Non-steroidal anti-inflammatory drugs inhibit the processes of mucosal cell proliferation associated with duodenal ulcer healing.

    abstract::We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection technique was used to quantitate mitosis in duodenal crypts at the ulcer edge, giving a regeneration ind...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200987

    authors: Levi S,Goodlad RA,Lee CY,Stamp G,Walport MJ,Wright NA,Hodgson HJ

    更新日期:1992-01-01 00:00:00

  • Serological and clinical follow-up of relatives of celiac disease patients from southern Brazil.

    abstract:BACKGROUND/AIMS:In this study, a clinical and serological follow-up of 8-10 years was performed in relatives of celiac disease (CD) patients from southern Brazil. The occurrence of new CD cases in the families and the use of two different IgA-tTG enzyme-linked immunosorbent assay (ELISA) kits were also evaluated. METH...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000320451

    authors: Nass FR,Kotze LM,Nisihara RM,de Messias-Reason IJ,Ramos da Rosa Utiyama S

    更新日期:2011-01-01 00:00:00

  • Prospective evaluation of pain in exocrine pancreatic cancer.

    abstract:BACKGROUND:Although pain is the most feared part of the terminal life of many patients with cancer, the intensity and the quality of the pain is all too often only scantly described. METHOD:The quality and quantity of pain were prospectively registered by five variables, including a visual analogue scale (VAS), in 46 ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201499

    authors: Grahm AL,Andrén-Sandberg A

    更新日期:1997-01-01 00:00:00

  • Faecal characteristics and colonic intraluminal pressure in diverticular disease.

    abstract::Daily faecal calcium and magnesium outputs were inversely related to food-stimulated colonic intraluminal pressure in diverticular disease subjects. There was no relationship to sodium potassium and bile acid concentrations, nor to intestinal transit. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198481

    authors: Eastwood MA,Smith AN,Mitchell WD,Pritchard JL

    更新日期:1980-01-01 00:00:00

  • Postheparin plasma diamine oxidase in subjects with small bowel disease. Diagnostic efficiency of a simplified test.

    abstract::Diamine oxidase (DAO) is an enzyme located almost exclusively in the villus tip enterocytes of mammals. Its plasma activity, normally very low, is enhanced by intravenous heparin that releases the enzyme from the enterocytes into the blood. Postheparin plasma DAO (PHD) values have been shown to be significantly reduce...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199731

    authors: D'Agostino L,Daniele B,Pignata S,Greco L,Mazzacca G

    更新日期:1988-01-01 00:00:00

  • Hydrokinetic activity of secretion and secretin analogues, modified in the N-terminal sequence, and of vasoactive intestinal peptide in the dog pancreas.

    abstract::In the dog pancreas in vivo, the biological activity of secretin and vasoactive intestinal peptide was compared to that of secretin analogues modified in their N-terminal hexapeptide and to X-secretion (alpha, beta-Asp3-secretin) and Y-secretin (a conversion product of X-secretin consisting of about 15% secretin and 8...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198600

    authors: Lehnert P,Forell MM,Jaeger E,Moroder L,Wünsch E

    更新日期:1981-01-01 00:00:00

  • Pancreatitis-associated protein (HIP/PAP) gene expression is upregulated in NOD mice pancreas and localized in exocrine tissue during diabetes.

    abstract::We have previously shown a specific significant overexpression in the exocrine pancreatic tissue of two members of the regenerating gene multifamily: reg I and reg II in the non-obese diabetic (NOD) mouse during active diabetogenesis. To strengthen the hypothesis that the overexpression of these genes may represent a ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000048867

    authors: Baeza N,Sanchez D,Christa L,Guy-Crotte O,Vialettes B,Figarella C

    更新日期:2001-01-01 00:00:00

  • Expression of a hypoxia-associated protein, carbonic anhydrase-9, correlates with malignant phenotypes of gastric carcinoma.

    abstract:BACKGROUND/AIMS:Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydras...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000297208

    authors: Kato Y,Yashiro M,Noda S,Kashiwagi S,Matsuoka J,Fuyuhiro Y,Doi Y,Hirakawa K

    更新日期:2010-01-01 00:00:00

  • Validity of a novel biopsy urease test (HUT) and a simplified 13C-urea breath test for diagnosis of Helicobacter pylori infection and estimation of the severity of gastritis.

    abstract::This prospective study was designed to validate a novel biopsy urease test as well as a simplified 13C-urea breath test for the detection of Helicobacter pylori. In addition, the hypothesis was tested that both the reaction velocity of the urease test and the 13CO2 excess of the urea breath test may allow a prediction...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201366

    authors: Labenz J,Bärsch G,Peitz U,Aygen S,Hennemann O,Tillenburg B,Becker T,Stolte M

    更新日期:1996-11-01 00:00:00

  • Regulation of pancreatic polypeptide release is mediated through M3 muscarinic receptors.

    abstract::The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201168

    authors: Tanikawa M,Hayakawa T,Kondo T,Naruse S,Shibata T,Kitagawa M

    更新日期:1994-01-01 00:00:00

  • Variable effect of lithium on canine pancreatic polypeptide and gastrin release by a meal or bombesin.

    abstract::Lithium is a cation which has central nervous system effects and is able to interfere with both the release and action of polypeptide hormones. We examined its effect on basal and stimulated plasma gastrin and pancreatic polypeptide (PP) levels in 4 dogs with chronic gastric fistulas. Gastrin and PP release were stimu...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198642

    authors: Modlin IM,Ehrlich BE,Lamers CB,Diamond JM,Walsh JH

    更新日期:1981-01-01 00:00:00

  • Celecoxib inhibits apurinic/apyrimidinic endonuclease-1 expression and prevents gastric cancer in Helicobacter pylori-infected mongolian gerbils.

    abstract:BACKGROUND AND AIMS:The aim of this study was to see whether administration of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, could prevent the development of gastric cancer via inhibition of apurinic/apyrimidinic endonuclease-1 (APE-1) expression induced by Helicobacter pylori infection. METHODS:70 Mongol...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000167978

    authors: Futagami S,Kawagoe T,Horie A,Shindo T,Hamamoto T,Suzuki K,Kusunoki M,Miyake K,Gudis K,Tsukui T,Crowe SE,Sakamoto C

    更新日期:2008-01-01 00:00:00

  • Fate of pancreatic enzymes in the human intestinal lumen in health and pancreatic insufficiency.

    abstract::The activities of pancreatic enzymes decrease during their passage from the duodenum to the terminal ileum, but degradation rates of individual enzymes are different. Whereas lipase activity is lost most rapidly, proteases and amylase are more stable. The mechanism by which lipase activity is destroyed is proteolysis,...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201097

    authors: Layer P,Gröger G

    更新日期:1993-01-01 00:00:00