Abstract:
BACKGROUND:Fecal lactoferrin has been introduced as a useful tool for the diagnosis and monitoring of inflammatory bowel disease (IBD). The aim of this study was to assess if fecal lactoferrin can be employed to predict or estimate the effect of granulocyte and monocyte adsorptive apheresis (GMA) in ulcerative colitis (UC). METHODS:This was a prospective study involving 21 patients with UC. Patients with moderately-to-severely active UC who were scheduled to undergo GMA were recruited. Changes in fecal lactoferrin concentration were compared between the GMA-responder and -nonresponder groups. RESULTS:In the GMA-responder group, fecal lactoferrin significantly increased 1 week after the introduction of GMA and then significantly decreased after GMA sessions. Fecal lactoferrin concentrations were significantly higher in the GMA-responder group than in the GMA-nonresponder group at 1 and 2 weeks after the introduction of GMA. Multivariate logistic regression analysis revealed that fecal lactoferrin concentration 1 week after the introduction of GMA was the most contributing factor for the effectiveness of GMA in patients with UC. CONCLUSIONS:In the GMA-responder group, fecal lactoferrin concentration significantly increased 1 week after the introduction of GMA. Fecal lactoferrin may be beneficial for predicting clinical response of GMA in patients with UC at an early stage of GMA treatment.
journal_name
Digestionjournal_title
Digestionauthors
Hashiguchi K,Takeshima F,Akazawa Y,Matsushima K,Minami H,Machida H,Yamaguchi N,Shiozawa K,Ohba K,Ohnita K,Ichikawa T,Isomoto H,Nakao Kdoi
10.1159/000375301subject
Has Abstractpub_date
2015-01-01 00:00:00pages
208-17issue
3eissn
0012-2823issn
1421-9867pii
000375301journal_volume
91pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND AND AIMS:Capsule endoscopy (CE) has been recognised as an important investigational tool in the diagnosis of gastrointestinal disease. Studies have shown that CE can identify lesions in the upper gastrointestinal tract as well as in the small intestine. However, contrary to conventional oesophagogastroscopy ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000089959
更新日期:2005-01-01 00:00:00
abstract::The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198954
更新日期:1983-01-01 00:00:00
abstract::Hepatitis B surface antigen (HBsAg)-associated receptors for polymerized human serum albumin (RpHSA) are assumed to mediate viral attachment to hepatocytes in hepatitis B virus (HBV) infection. RpHSA was found to be coded by the pre-S region of HBV genome. Recently, the antiviral effect of recombinant leukocyte alpha-...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199474
更新日期:1987-01-01 00:00:00
abstract::Mechanisms of antisecretory action of intragastric FPL-52694, a mast cell stabilizer, were investigated in anesthetized rats. In Schild's rat preparation, intravenous FPL-52694 (10 mg/kg) significantly suppressed acid secretion in response to only tetragastrin (20 micrograms/kg, i.v.) (42.1 +/- 19.4%), while intragast...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199339
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Although pain is the most feared part of the terminal life of many patients with cancer, the intensity and the quality of the pain is all too often only scantly described. METHOD:The quality and quantity of pain were prospectively registered by five variables, including a visual analogue scale (VAS), in 46 ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201499
更新日期:1997-01-01 00:00:00
abstract::5 healthy volunteers were submitted to i.v. infusion for 45 min of graded doses of commercial GIH secretin (0.01, 0.025, 0.05, 0.5, 1 and 2 CU/kg h-1). Parathormone serum levels were measured before and during the infusion. All the dosages of exogenous secretin were followed by a significant increase in serum PTH leve...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198678
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to examine the relationship between narrow-band imaging (NBI) magnifying observation using the surface pattern as the main evaluation criterion and pit pattern diagnosis on the basis of magnifying observation using a dye in relation to the characteristics of colorectal tumors ac...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000343940
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510353
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:Gut microbiota affects host homeostasis and dysbiosis causes host diseases. Therefore, uncovering the sensing mechanism of bacterial metabolites such as short-chain fatty acid (SCFA) may help us to understand the host-microbiota interaction both in physiological and nonphysiological conditions. SUMMARY:The ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000356211
更新日期:2014-01-01 00:00:00
abstract::It is now generally admitted that phytohemagglutinin (PHA) constitutes the main factor responsible for the dietary toxicity of raw kidney beans. In the growing rat, an impairment of growth is the unique expression of a malnutrition syndrome. The aim of this work was to precise to what extent the intestinal injuries ma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199736
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Crohn's disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. The pathophysiological understanding of this disease is limited and no curative therapy is available so far. Therefore, most patients require long-lasting or even life-long immunosuppressive therapies for the suppressio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000488449
更新日期:2018-01-01 00:00:00
abstract::The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199357
更新日期:1986-01-01 00:00:00
abstract::Electroencephalographic tracings of 50 patients with ulcerative colitis (UC) were compared with those of 75 controls. In the UC patients a 24% incidence of abnormal tracings was found as compared with an 8% incidence in the controls. A higher incidence of abnormal electroencephalograms was found among active cases of ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197695
更新日期:1975-01-01 00:00:00
abstract::Familial colorectal cancer (CRC) is heterogeneous. Screening recommendations do exist for individuals with a mild to moderate family history of CRC, with or without early age at onset. However, most attention has properly focused on the identification of individuals in whom a defined susceptibility gene mutation can b...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000108395
更新日期:2007-01-01 00:00:00
abstract::Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051452
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051928
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Only the depth of submucosal invasion can be estimated prior to determining the indications for endoscopic submucosal dissection (ESD) as a curative treatment for colorectal carcinoma (CRC). Here we evaluated the outcomes of ESD for clinical T1 CRCs. METHODS:Of 660 patients who underwent ESD for CRC at...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000368866
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The incidence of esophageal cancer is markedly increased in patients with head and neck cancer, and the presence of esophageal cancer is associated with reduced survival rates. AIMS:We investigated whether the results of screening for esophageal cancer in patients with head and neck cancer using chromoendos...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000094523
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:A patency capsule (PC) can help predict capsule endoscope (CE) retention; however, PC tolerability is unknown in children. We retrospectively evaluated PC tolerability in school-aged children. METHODS:Sixty-one patients (median age, 12.9 years; range 7.4-17.3 years) who underwent PC examination were analyze...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000477579
更新日期:2017-01-01 00:00:00
abstract::In the dog pancreas in vivo, the biological activity of secretin and vasoactive intestinal peptide was compared to that of secretin analogues modified in their N-terminal hexapeptide and to X-secretion (alpha, beta-Asp3-secretin) and Y-secretin (a conversion product of X-secretin consisting of about 15% secretin and 8...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198600
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to exactly determine the pH stability of human gastric lipase (HGL) and to investigate the mechanism underlying the inactivation of HGL which occurs in gastric juice. METHODS:Samples of human gastric juice and purified HGL were incubated at various pH values ranging from 0.5 t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000057708
更新日期:2002-01-01 00:00:00
abstract::A manometric study of the distal biliary tract was carried out by means of a side-hole perfused catheter passed through the papilla Vateri during duodenoscopy in patients with postcholecystectomy biliary pain not due to stones or inflammation of the biliary tree. The sphincter of Oddi showed in these cases a significa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198979
更新日期:1983-01-01 00:00:00
abstract::Growth hormone-releasing factor (GRF) was reported to possess the growth-promoting action on the gastroduodenal mucosa that can be augmented by removal of endogenous somatostatin. Since mucosal proliferation was considered to contribute to healing of chronic gastroduodenal ulcerations, we designed the study to determi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199763
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000464130
更新日期:2017-01-01 00:00:00
abstract::The basal (interdigestive) gastrointestinal motor activity and the interdigestive gastric acid and pancreatic amylase secretion were determined in 10 young smokers (mean age 23 years) and 7 nonsmokers (mean age 26 years). There was no significant difference in the length of the interdigestive motor complex between smo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199018
更新日期:1984-01-01 00:00:00
abstract::The influences of secretagogues and of elevated serum calcium concentrations on the calcium secretion from the cat pancreas have been studied in vivo. During a high and constant fluid secretion rate evoked by a background infusion of secretin, additional infusions of both cholecystokinin-pancreozymin and urecholine le...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198873
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000502953
更新日期:2019-09-18 00:00:00
abstract::The aim of the study was to define the effects of sex, age, smoking, alcohol, analgesic ingestion, and treatment method whereby healing was initially induced on the prognosis of patients with a chronic duodenal ulcer (DU). 122 patients were assessed 1 year after the endoscopic demonstration of a DU. Two outcome variab...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199171
更新日期:1985-01-01 00:00:00
abstract::In an attempt to evaluate a possible correlation between cryptogenic chronic liver disease and a present or past hepatitis B virus (HBV) infection, we studied 17 patients with hepatitis B surface antigen (HBsAg)-negative, nonalcoholic chronic liver disease; 9 of them were positive for serum HBsAg detected by a solid-p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199633
更新日期:1988-01-01 00:00:00
abstract::High-fidelity simulation uses simulators that combine all of the physiological and pharmacological responses of a human in a manikin. These simulators change and respond to the users and trainees. Using simulators for teaching sedation in the field of gastroenterology unifies all the advantages of manikins. To underst...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000287214
更新日期:2010-01-01 00:00:00