Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules.

abstract：:The activities of pancreatic enzymes decrease during their passage from the duodenum to the terminal ileum, but degradation rates of individual enzymes are different. Whereas lipase activity is lost most rapidly, proteases and amylase are more stable. The mechanism by which lipase activity is destroyed is proteolysis,...

journal_title：Digestion

authors： Layer P,Gröger G

更新日期：1993-01-01 00:00:00

abstract：:Rats were subjected to serial venesections 3 days prior to and then sequentially for 4 weeks after surgical removal of either the proximal or distal half of the small bowel. Total serum protein concentration and protein electrophoretic patterns were determined on these sera. Both sham-operated and unoperated animals s...

journal_title：Digestion

authors： Urban E,Ricks PM

更新日期：1980-01-01 00:00:00

abstract：:23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...

journal_title：Digestion

authors： Bernardi M,Servadei D,Trevisani F,Rusticali AG,Gasbarrini G

更新日期：1985-01-01 00:00:00

abstract：:Several previous studies have shown that the plasma concentration of gamma-amino-butyric acid (GABA) is markedly increased in patients with hepatic encephalopathy, and it has been suggested that decreased metabolism of peripheral GABA might contribute to the cerebral dysfunctions observed. In the present study, plasma...

journal_title：Digestion

authors： Löscher W,Kretz FJ,Karavias T,Dillinger U

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Currently, use of the Bravo capsule is a very common method for evaluating the gastroesophageal reflux because it has the advantage of being an intraesophageal catheter-free system. However, endoscopic removal of the capsule is necessary when technical problems or severe discomfort are present. Most frequent...

journal_title：Digestion

authors： de Hoyos A,Esparza EA,Loredo ML

更新日期：2009-01-01 00:00:00

abstract：:The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 ...

journal_title：Digestion

authors： Wereszczyńska-Siemiatkowska U,Pohl U,Otto J,Lankisch PG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Many studies have recently been published on acute pancreatitis; however, few large-sample studies have been focused on the risk factors for deaths in severe acute pancreatitis. To address this issue, the present study was intended to assess etiology, severity, and mortality of acute pancreatitis in the...

journal_title：Digestion

authors： Bai Y,Jia L,Wang B,Yang B,Wang L,Shi X,Zhang W,Liu Y,Zou D,Li Z

更新日期：2007-01-01 00:00:00

abstract：:We have shown that dietary long-chain triglycerides and 16,16-dimethyl prostaglandin E2 enhance and aspirin impairs postresection mucosal adaptation in rats. The present studies examined the hypothesis that supplemental linoleic acid (LA) above the minimum requirement may enhance postresection mucosal adaptation throu...

journal_title：Digestion

authors： Park JH,Grandjean CJ,Hart MH,Baylor JM,Vanderhoof JA

更新日期：1989-01-01 00:00:00

abstract：:One to four months after implantation of a gastric fistula, a circadian rhythm in gastric acidity could be demonstrated by use of the intragastric 24-hour pH-metry in dogs with the gastric fistula protruding on the left side of the upper abdomen. This circadian rhythm was found to be fully developed within 3 years, an...

journal_title：Digestion

authors： Postius S,Bräuer U

更新日期：1995-01-01 00:00:00

abstract：:The effect of the new antiulcer agent plaunotol on the release of endogenous secretin and the pancreatic exocrine secretion was investigated in anesthetized rats. In 48 rats with pancreatic and biliary diversion, continuous intraduodenal infusion of plaunotol in 3 graded doses (5, 20 and 80 mg/h/rat) resulted in signi...

journal_title：Digestion

authors： Chang JH,Watanabe S,Shiratori K,Moriyoshi Y,Takeuchi T

更新日期：1989-01-01 00:00:00

abstract：:Chornic exogenous administration of cholecystokinin octapeptide (CCK8) to rats led to a reduced sensitivity of pancreatic acinar cells to both CCK8 and carbachol stimulation without changes in affinity or number of CCK or muscarinic receptors. In addition, repeated feeding of camostate, a synthetic protease inhibitor ...

journal_title：Digestion

authors： Herzig KH,May D,Louie DS,Takahashi T,Göke B,Owyang C

更新日期：1990-01-01 00:00:00

abstract：:We have previously shown a specific significant overexpression in the exocrine pancreatic tissue of two members of the regenerating gene multifamily: reg I and reg II in the non-obese diabetic (NOD) mouse during active diabetogenesis. To strengthen the hypothesis that the overexpression of these genes may represent a ...

journal_title：Digestion

authors： Baeza N,Sanchez D,Christa L,Guy-Crotte O,Vialettes B,Figarella C

更新日期：2001-01-01 00:00:00

abstract：:The case of a 52-year-old male with chronic active type B hepatitis in whom severe exacerbation of liver disease was associated with interferon alpha treatment is described. It seems that patients with very active forms of chronic hepatitis B may experience severe and symptomatic exacerbation of liver disease during i...

journal_title：Digestion

authors： Laskus T,Radkowski M,Slusarczyk J,Cianciara J

更新日期：1992-01-01 00:00:00

abstract：:The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...

journal_title：Digestion

authors： Köhler H,Becker HD

更新日期：1987-01-01 00:00:00

abstract：:The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...

journal_title：Digestion

authors： Tanikawa M,Hayakawa T,Kondo T,Naruse S,Shibata T,Kitagawa M

更新日期：1994-01-01 00:00:00

abstract：:We report on a 39-year-old woman suffering from deep venous thrombosis due to a heterozygous factor-V-Leiden mutation with resistance to activated protein C. Four months after beginning oral anticoagulation, generalized jaundice appeared. Subsequently, subacute liver failure developed necessitating an orthotopic liver...

journal_title：Digestion

authors： Mix H,Wagner S,Böker K,Gloger S,Oldhafer KJ,Behrend M,Flemming P,Manns MP

更新日期：1999-11-01 00:00:00

abstract：:5 adrenalectomized subjects and 8 healthy volunteers underwent an insulin test during which acid secretion and plasma adrenaline, noradrenaline, dopamine and gastrin concentrations were measured. Plasma glucose concentration fell by greater than 50% in all subjects. The mean plasma adrenaline concentration increased m...

journal_title：Digestion

authors： Järhult J,Hamberger B,Lanthén G,Ors M,Uvnäs-Wallensten K

更新日期：1981-01-01 00:00:00

abstract：:The surface epithelial cells of the gastroduodenal mucosa are thought to be protected from the damaging effects of acid by a covering layer of mucus into which is secreted bicarbonate. It is proposed here that mucus acts as a true barrier to hydrogen ion diffusion, and that the role played by bicarbonate is to adjust ...

journal_title：Digestion

authors： Vadgama P,Alberti KG

更新日期：1983-01-01 00:00:00

abstract：:6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...

journal_title：Digestion

authors： Holdstock GE,Fisher JA,Hamblin TJ,Loehry C

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND/AIM:Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most ...

journal_title：Digestion

authors： van Kerkhoven LA,van Rijswijck SJ,van Rossum LG,Laheij RJ,Witteman EM,Tan AC,Jansen JB

更新日期：2007-01-01 00:00:00

abstract：:The incidence of steatorrhea is said to be lower and its grade milder in Japanese because their fat intake is lower than that of Europeans and Americans. Failure to take this into account creates difficulties when attempting to compare data on pancreatic exocrine insufficiency in different countries. The authors exami...

journal_title：Digestion

authors： Nakamura T,Tando Y,Yamada N,Watanabe T,Ogawa Y,Kaji A,Imamura K,Kikuchi H,Suda T

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed at (i) clarifying the factors associated with high scores on the modified frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) among 3,505 relatively healthy subjects undergoing routine medical health checkups with gastrointestinal endoscopy and (ii) comparing risk...

journal_title：Digestion

authors： Takeshita E,Sakata Y,Hara M,Akutagawa K,Sakata N,Endo H,Ohyama T,Matsunaga K,Yoshioka T,Kawakubo H,Tanaka Y,Shirai S,Ito Y,Tsuruoka N,Iwakiri R,Kusano M,Fujimoto K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach. METHODS:Suckling rats were prematurely weaned on postnatal day 15 and followed through...

journal_title：Digestion

authors： Lin CH,Lyons H,Seelbach MS,Tolia V,Vijesurier R

更新日期：2001-01-01 00:00:00

abstract：:Cell renewal in the duodenal mucosa of Mastomys was studied by autoradiography 1 and 24 h after intraperitoneal injection of tritiated thymidine. Non-specific duodenitis and duodenal ulceration were produced with a continuous infusion of histamine. Mucosal renewal in the duodenum of 30 control Mastomys was compared wi...

journal_title：Digestion

authors： Smedley FH,Rimmer J,Samanidis A,Wastell C

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:A patency capsule (PC) can help predict capsule endoscope (CE) retention; however, PC tolerability is unknown in children. We retrospectively evaluated PC tolerability in school-aged children. METHODS:Sixty-one patients (median age, 12.9 years; range 7.4-17.3 years) who underwent PC examination were analyze...

journal_title：Digestion

authors： Tokuhara D,Watanabe K,Cho Y,Shintaku H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD). METHODS:Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administere...

journal_title：Digestion

authors： Taniguchi T,Tsukada H,Nakamura H,Kodama M,Fukuda K,Tominaga M,Seino Y

更新日期：1997-01-01 00:00:00

abstract：AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

journal_title：Digestion

authors： Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

更新日期：2001-01-01 00:00:00

abstract：:Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...

journal_title：Digestion

authors： Heim HK,Oestmann A,Thiele H,Sewing KF

更新日期：1989-01-01 00:00:00

abstract：:The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. During the active phase of the disease, the NO3 excretion was significantly higher in the patients than in healthy controls (n = 6, p < 0....

journal_title：Digestion

authors： Sasajima K,Yoshida Y,Yamakado S,Sato J,Miyashita M,Okawa K,Matsutani T,Onda M,Kawano E

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND/AIMS:Adenosine deaminase (ADA)-deficient disease, a severe combined immunodeficiency, is most commonly associated with gastrointestinal disorders such as ulcer. The present study investigated the role of ADA in the pathogenesis of gastric ulcer. METHODS:ADA activity was measured in a variety of organs and t...

journal_title：Digestion

authors： Yaguchi T,Saito M,Yasuda Y,Nishizaki T

更新日期：2010-01-01 00:00:00