Abstract:
:Biliopancreatic bypass (BPB), a bariatric surgical procedure, leads to a malnutrition-induced general visceral atrophy except for the pancreas. This work investigates the implication of cholecystokinin (CCK) in the exocrine pancreatic adaptive process using a plasma CCK assay and the CCK receptor antagonist CR 1409. No significant reduction in weight and DNA content of the pancreas was noted 36 days after BPB, while a strong decrease in protein, enzymes and RNA contents indicating cellular hypotrophy became apparent. CR 1409 treatment strongly depressed pancreatic weight and its DNA content in BPB animals, suggesting an additional hypoplasia; however, the reduction in pancreatic enzyme content was not aggravated. BPB increased plasma CCK concentrations by 160%, unrelated to CR 1409 treatment. These results indicate that: (1) CCK is involved in the pancreatic adaptive response after BPB in rats, and (2) in the context of a protein malnutrition state, CCK dissociates its pancreatic growth and enzymatic effects, favouring the former.
journal_name
Digestionjournal_title
Digestionauthors
Evrard S,Hoeltzel A,Aprahamian M,Bernard C,Mutter D,Marescaux J,Damgé Cdoi
10.1159/000201149subject
Has Abstractpub_date
1994-01-01 00:00:00pages
208-13issue
4eissn
0012-2823issn
1421-9867journal_volume
55pub_type
杂志文章相关文献
DIGESTION文献大全abstract::The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. During the active phase of the disease, the NO3 excretion was significantly higher in the patients than in healthy controls (n = 6, p < 0....
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201332
更新日期:1996-01-01 00:00:00
abstract::Omeprazole was administered for up to 6 years in 859 patients for 'prevention of relapse in patients with poorly responsive peptic ulcer or reflux oesophagitis'. The pattern of adverse events reported during long-term treatment was similar to the adverse-event profile in short-term treatment with omeprazole (n = 2,818...
journal_title:Digestion
pub_type: 杂志文章,meta分析
doi:10.1159/000200922
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Crohn's disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. The pathophysiological understanding of this disease is limited and no curative therapy is available so far. Therefore, most patients require long-lasting or even life-long immunosuppressive therapies for the suppressio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000488449
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:L-glutamine (L-gln) is a conditionally essential amino acid which is consumed by certain tissues like the intestine in large amounts as energy source during critical illness. Apart from nutritive action, recent data suggest a link to heat-shock protein (hsp) induction. We investigated the effect of L-gl...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000048844
更新日期:2001-01-01 00:00:00
abstract::The effects of gastric fundectomy and antrectomy on the colonic mucosa were studied in hamsters over 5 and 25 days. Sham-operated animals served as controls. Basal plasma gastrin concentrations were significantly increased after fundectomy and significantly decreased after antrectomy. Five days after fundectomy, there...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200968
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Transition-related healthcare intervention has recently been receiving worldwide attention. Given the increasing incidence of pediatric inflammatory bowel disease (IBD) and its lifelong impact, transitional care has become an important issue. In Japan, guidelines to support the autonomy of IBD patients durin...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000510652
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051879
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND AND AIM:Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METH...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000487045
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:At present, benefits of surgical resection and appropriate selection criteria in patients affected by both hepatic and pulmonary metastases of colorectal cancer (CRC) are under discussion. Our analysis focused on a surgical series of such patients and our final aim consisted in identifying potential pro...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000497223
更新日期:2020-01-01 00:00:00
abstract::The role of altered gastric motor functions for the development of obesity is still unclear. In this study, we investigated whether severe obesity is related to gastric dysfunctions or to abnormal perception in response to distension. 31 obese patients and 20 healthy volunteers were studied using an electronic barosta...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201433
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIMS:Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS:An expert international group using the modified Delphi technique examined the q...
journal_title:Digestion
pub_type: 共识发展会议,杂志文章
doi:10.1159/000219365
更新日期:2009-01-01 00:00:00
abstract::Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled. In this study performed on 16 young male subjects, gastric acid secretion and emptying rate were determined after intragastric administration of 8% pep...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200218
更新日期:1990-01-01 00:00:00
abstract::In rats we studied the effects of lactoferrin on experimental acute pancreatitis caused by a single subcutaneous injection of 100 micrograms/kg body weight of caerulein. Lactoferrin isolated from human milk was given intraperitoneally to rats immediately after the injection of caerulein. The injection of 100 mg/kg bod...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201018
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000328694
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Polyamine uptake from the circulation plays an important role in the maintenance of the intracellular polyamine content during extensive proliferation in intestinal mucosal cells. METHODS:Isolated basolateral membrane vesicles of the rabbit enterocyte were used to characterize polyamine transport acros...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007468
更新日期:1998-01-01 00:00:00
abstract::Somatostatin (SST) has been shown to induce cholestasis in the dog and in the rat. In man, it is still unknown whether SST modifies bile formation. The present study was undertaken to examine the influence of SST on bile secretion in man. Two volunteers who had a total external biliary fistula received 1-hour SST infu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199820
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND/AIMS:To identify the number and potential causes of unnecessary diagnostic procedures in a cohort of patients with autoimmune pancreatitis (AIP). METHODS:All AIP cases at our centre between April 2006 and April 2013 were collected and followed up. Diagnosis was established by the International Consensus Dia...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000437259
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIM:True adenomas of the cardia appear to be extremely rare lesions. There are no data on the natural history and histopathological background of these lesions. We report 3 patients with true adenomas of the cardia. METHODS AND RESULTS:Three patients with polypoid masses at the cardia below the Z-line were ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000121413
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD). METHODS:Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administere...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201486
更新日期:1997-01-01 00:00:00
abstract::We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198753
更新日期:1982-01-01 00:00:00
abstract::The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198068
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Medical therapy of inflammatory bowel disease (IBD) is becoming more complex, given the increasing choice of drugs to treat Crohn's disease (CD) and ulcerative colitis (UC). We aimed to summarize the current guidelines for first-line treatments in IBD. METHODS:An extensive literature search with fo...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000341951
更新日期:2012-01-01 00:00:00
abstract::Germ-free and conventional rats were fed a semi-synthetic diet including 10% wheat bran for 1 month. They were compared to similar rats fed the same diet without bran. Transit of polyethylene glycol (PEG) 4000 was studied in giving the marker either in saline or in the diet. The presence of a bacterial flora was found...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199006
更新日期:1984-01-01 00:00:00
abstract::The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg ...
journal_title:Digestion
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000200522
更新日期:1990-01-01 00:00:00
abstract::We report on a 39-year-old woman suffering from deep venous thrombosis due to a heterozygous factor-V-Leiden mutation with resistance to activated protein C. Four months after beginning oral anticoagulation, generalized jaundice appeared. Subsequently, subacute liver failure developed necessitating an orthotopic liver...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007710
更新日期:1999-11-01 00:00:00
abstract::The diagnostic value of serum ferritin levels was evaluated in 19 patients with biopsy-proven primary hepatocellular carcinoma (PHC) and 26 patients with chronic liver disease (CLD). Serum ferritin levels were significantly elevated in PHC, as compared with CLD and controls (p less than 0.0005). Similarly, serum ferri...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199114
更新日期:1984-01-01 00:00:00
abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198344
更新日期:1979-01-01 00:00:00
abstract::Familial colorectal cancer (CRC) is heterogeneous. Screening recommendations do exist for individuals with a mild to moderate family history of CRC, with or without early age at onset. However, most attention has properly focused on the identification of individuals in whom a defined susceptibility gene mutation can b...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000108395
更新日期:2007-01-01 00:00:00
abstract::The activities of pancreatic enzymes decrease during their passage from the duodenum to the terminal ileum, but degradation rates of individual enzymes are different. Whereas lipase activity is lost most rapidly, proteases and amylase are more stable. The mechanism by which lipase activity is destroyed is proteolysis,...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201097
更新日期:1993-01-01 00:00:00
abstract::Leucine absorption across the mechanically obstructed rat intestine was studied by in vivo and in vitro techniques. It varied between the early (after 2 h) and late (after 18 h) phases of the obstruction. During the early phase there was a reduction in mucosal uptake and in net absorption of the amino acid. At 18 h th...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198838
更新日期:1982-01-01 00:00:00