Abstract:
:Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 mM) increased the enzyme activity 3.0 and 1.6 fold, respectively. The concentrations of prostacyclin and prostaglandin E2 required to produce half maximal activation were in the same range. Prostacyclin is an efficient stimulator of human gastric mucosal adenylate cyclase.
journal_name
Digestionjournal_title
Digestionauthors
Simon B,Kather Hdoi
10.1159/000198335subject
Has Abstractpub_date
1979-01-01 00:00:00pages
137-9issue
2eissn
0012-2823issn
1421-9867journal_volume
19pub_type
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