Virus-associated receptors for polymerized human serum albumin (RpHSA) in patients with chronic active hepatitis B treated with recombinant leukocyte A interferon.

Abstract:

:Hepatitis B surface antigen (HBsAg)-associated receptors for polymerized human serum albumin (RpHSA) are assumed to mediate viral attachment to hepatocytes in hepatitis B virus (HBV) infection. RpHSA was found to be coded by the pre-S region of HBV genome. Recently, the antiviral effect of recombinant leukocyte alpha-interferon was shown in patients with hepatitis B. Our study evaluated the detection and the clinical implications of RpHSA in patients with chronic active hepatitis B under treatment with recombinant alpha-interferon. Two out of nine patients eliminated all HBV markers including RpHSA. Four out of nine patients became negative for markers of viral replication but remained positive for HBsAg and in part for RpHSA. In three out of nine patients HBV markers including RpHSA remained unchanged. In summary, the titer for RpHSA is a reliable indirect marker for infectivity and of prognostic value in patients with chronic active hepatitis B during interferon treatment. Future studies should evaluate a putative immune response to RpHSA-containing viral surface proteins, which could be relevant for viral clearance in HBV infection.

journal_name

Digestion

journal_title

Digestion

authors

Gerken G,Manns M,Hess G,Meyer zum Büschenfelde KH

doi

10.1159/000199474

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

96-102

issue

2

eissn

0012-2823

issn

1421-9867

journal_volume

37

pub_type

杂志文章
  • Rat small intestinal laminin-binding proteins.

    abstract::Mucosal intestinal cells migrate and differentiate simultaneously as they move out of the crypts to their functional site along the villus. Interactions between the enterocyte basal membrane domain and the extracellular intestinal basement membrane (IBM) have been suggested to be essential to both cell migration and d...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200363

    authors: Wilson JR,Weiser MM

    更新日期:1990-01-01 00:00:00

  • Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms.

    abstract:INTRODUCTION:We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated w...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000511589

    authors: Esaki M,Yamamura T,Nakamura M,Maeda K,Sawada T,Mizutani Y,Ishikawa E,Suzuki H,Kuno T,Yamada K,Hasegawa I,Ishikawa T,Kakushima N,Furukawa K,Ohno E,Kawashima H,Hirooka Y,Fujishiro M

    更新日期:2020-11-18 00:00:00

  • Existence of variant gamma delta T cells in Crohn's disease.

    abstract:BACKGROUND AND OBJECTIVES:gamma delta T cell populations are well-known for their unique distribution (e.g. intra-epithelial lymphocytes). Though their ligands play a major role in the immune response they have remained largely obscure. To shed light on this issue, we have analyzed in this study the complementarity det...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051911

    authors: Ishiguro Y,Kanazawa H,Yamagata K,Sakuraba H,Munakata A

    更新日期:2001-01-01 00:00:00

  • Double-Filtration Plasmapheresis plus Interferon-β for HCV-1b Patients with Non-Sustained Virological Response to Previous Combination Therapy.

    abstract:BACKGROUND AND AIMS:Double-filtration plasmapheresis (DFPP) together with interferon (IFN) administration produces a substantial reduction in the viral load during the early stages of treatment. METHODS:Based on their responses to previous pegylated IFN and ribavirin (PEG-IFN/RBV) therapy, 20 patients were divided int...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000333209

    authors: Kim SR,Saito J,Imoto S,Komaki T,Nagata Y,Kim KI,Sasase N,Kimura N,Sasatani K,Konishi E,Hasegawa Y,Fujinami A,Ohta M,El-Shamy A,Tanaka Y,Sugano M,Sakashita M,Nakamura A,Tsuchida S,Makino T,Kawada T,Nakajima T,M

    更新日期:2011-01-01 00:00:00

  • Isoproterenol Disrupts Intestinal Barriers Activating Gut-Liver-Axis: Effects on Intestinal Mucus and Vascular Barrier as Entry Sites.

    abstract:BACKGROUND:The gut-liver-axis presents the pathophysiological hallmark for multiple liver diseases and has been proposed to be modulated during stress and shock. Access to the gut-liver-axis needs crossing of the mucus and gut-vascular barrier. The role of β-adrenoreceptor-activation for both barriers has not been defi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000502112

    authors: Sorribas M,de Gottardi A,Moghadamrad S,Hassan M,Spadoni I,Rescigno M,Wiest R

    更新日期:2020-01-01 00:00:00

  • Corticosteroid Therapy Improves the Outcome of Autoimmune Hepatitis-Induced Acute Liver Failure.

    abstract:BACKGROUND/AIMS:Autoimmune hepatitis (AIH) is a relatively rare cause of liver dysfunction and may lead in some cases to acute liver failure (ALF). The aim of our study was to evaluate the clinical course and outcome of patients with AIH-induced ALF. METHODS:We retrospectively enrolled 32 patients with AIH-induced ALF...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000487940

    authors: Anastasiou OE,Dogan-Cavus B,Kucukoglu O,Baba H,Kahraman A,Gerken G,Schramm C,Canbay A

    更新日期:2018-01-01 00:00:00

  • Efficacy of Upper Gastrointestinal Endoscopic Examination to Identify Patients with Obstructive Sleep Apnea Syndrome: A Retrospective Cross-Sectional Study.

    abstract:BACKGROUND/AIMS:Despite the high prevalence of obstructive sleep apnea syndrome (OSAS), most individuals are unaware of its diagnosis. We assessed whether an upper gastrointestinal (GI) endoscopy can accurately predict the incidence of OSAS. METHODS:After endoscopic evaluation of laryngo-pharyngeal collapse, a total o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000491385

    authors: Ohata K,Sakai E,Nakao T,Kimoto Y,Ishii R,Konishi T,Ueno S,Takita M,Negishi R,Morinushi T,Muramoto T,Matsuhashi N,Nakaya T,Koba I,Nakaji S

    更新日期:2019-01-01 00:00:00

  • Polyamine uptake across the basolateral membrane of the enterocyte is mediated by a high-affinity carrier: a study using isolated basolateral membrane vesicles.

    abstract:BACKGROUND/AIMS:Polyamine uptake from the circulation plays an important role in the maintenance of the intracellular polyamine content during extensive proliferation in intestinal mucosal cells. METHODS:Isolated basolateral membrane vesicles of the rabbit enterocyte were used to characterize polyamine transport acros...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007468

    authors: Milovic V,Caspary WF,Stein J

    更新日期:1998-01-01 00:00:00

  • Clinicopathological Assessment of Gastric Xanthoma as Potential Predictive Marker of Gastric Cancer.

    abstract:BACKGROUND/AIMS:Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHOD...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000481346

    authors: Kitamura S,Muguruma N,Okamoto K,Tanahashi T,Fukuya A,Tanaka K,Fujimoto D,Kimura T,Miyamoto H,Bando Y,Takeuchi H,Shiba M,Takayama T

    更新日期:2017-11-01 00:00:00

  • Octreotide in the treatment of refractory diarrhea.

    abstract::Refractory chronic diarrhea that does not respond to specific antimicrobial therapy or standard unspecific medication may present a challenging and serious clinical problem. Octreotide is a candidate drug for the treatment of these patients as it inhibits gastrointestinal motility, pancreatic secretion and inhibits in...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000051479

    authors: Fried M

    更新日期:1999-01-01 00:00:00

  • Small intestinal edema had the strongest correlation with portal venous pressure amongst capsule endoscopy findings.

    abstract:BACKGROUND/AIM:Previous studies have reported small intestinal lesions in patients with portal hypertensive disease. However, the etiology of these lesions is not clear, as portal venous pressure was not measured in any of these studies. The aim of this study is to clarify the association between small intestinal lesio...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338180

    authors: Takahashi Y,Fujimori S,Narahara Y,Gudis K,Ensaka Y,Kosugi Y,Maki K,Suzuki M,Matsushita Y,Fukuda T,Kanazawa H,Sakamoto C

    更新日期:2012-01-01 00:00:00

  • In vivo and in vitro relationship between lipoprotein-X and bile salts in cholestasis.

    abstract::Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negati...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198402

    authors: Frisón JC,Ras MR,Rubiés-Prat J,Salvá JA,Masdeu S,Bacardí R

    更新日期:1979-01-01 00:00:00

  • Effect of cell proliferation on healing of gastric and duodenal ulcers in rats.

    abstract::The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199280

    authors: Takeuchi K,Johnson LR

    更新日期:1986-01-01 00:00:00

  • Functional expression of HGF and its receptor in human colorectal cancer.

    abstract:BACKGROUND:Hepatocyte growth factor (HGF) stimulates proliferation, migration and morphogenesis of epithelial cells by specific binding to its receptor c-met. Overexpression of HGF or c-met has been reported for human gastric or pancreatic cancer. In colorectal cancer overexpression of c-met but not HGF has been shown....

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007764

    authors: Otte JM,Schmitz F,Kiehne K,Stechele HU,Banasiewicz T,Krokowicz P,Nakamura T,Fölsch UR,Herzig K

    更新日期:2000-01-01 00:00:00

  • Long-Term Outcomes after Surgical Resection for Synchronous or Metachronous Hepatic and Pulmonary Colorectal Cancer Metastases.

    abstract:BACKGROUND/AIMS:At present, benefits of surgical resection and appropriate selection criteria in patients affected by both hepatic and pulmonary metastases of colorectal cancer (CRC) are under discussion. Our analysis focused on a surgical series of such patients and our final aim consisted in identifying potential pro...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000497223

    authors: Zizzo M,Galeone C,Braglia L,Ugoletti L,Siciliani A,Nachira D,Margaritora S,Pedrazzoli C,Paci M,Lococo F

    更新日期:2020-01-01 00:00:00

  • Cytoprotection of canine gastric mucosa by prostacyclin: possible mediation by increased mucosal blood flow.

    abstract:UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethano...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198824

    authors: Konturek SJ,Robert A

    更新日期:1982-01-01 00:00:00

  • Hymenolepiasis: an unusual cause of diarrhoea in Western Europe.

    abstract::A young Indian man presented in England with a 6-month history of diarrhoea which started just before leaving India. He was found to have tropical enteropathy and H. nana infestation, but while the infestation and symptoms disappeared with antihelminthic treatment, the tropical enteropathy persisted. Hymenolepiasis is...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198551

    authors: Cooper BT,Hodgson HJ,Chadwick VS

    更新日期:1981-01-01 00:00:00

  • Acute pancreatitis: when is enzyme treatment indicated?

    abstract::Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201102

    authors: McMahon MJ

    更新日期:1993-01-01 00:00:00

  • Evaluation of faecal occult blood test and lactoferrin latex agglutination test in screening hospitalized patients for diagnosing inflammatory and non-inflammatory diarrhoea in Dhaka, Bangladesh.

    abstract:BACKGROUND:Inflammatory diarrhoea (ID) resulting from Shigella, Salmonella, Campylobacter and Entamoeba histolytica requires specific diagnosis for therapy. Differentiation between ID and non-inflammatory diarrhoea (NID) is often not clinically possible. A faecal occult blood test (FOBT) correlates with faecal leucocyt...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000113042

    authors: Ashraf H,Beltinger J,Alam NH,Bardhan PK,Faruque AS,Akter J,Salam MA,Gyr N

    更新日期:2007-01-01 00:00:00

  • Predictors for Complicated Disease Course after Stepping Down from Combination to Antitumor Necrosis Factor Alpha Monotherapy in Children with Inflammatory Bowel Disease.

    abstract:OBJECTIVE:Combinations of antitumor necrosis factor alpha (TNFα) and immunomodulators may be indicated in high-risk inflammatory bowel disease patients. Our aims were to compare disease course between children that did and did not step down to anti-TNFα monotherapy and to define risk factors for complicated disease cou...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000496273

    authors: Yerushalmy-Feler A,Moran-Lev H,Galai T,Cohen S

    更新日期:2020-01-01 00:00:00

  • Gastric and colorectal cancer in patients attending mission hospitals in rural areas of South-east Asia.

    abstract::25 missionaries working in Taiwan, Thailand, Indonesia and the Philippines completed questionnaires regarding their clinical practice during the year 1980. Data were collected on the numbers of both gastric and colorectal cancers diagnosed. More than 90,000 out-patients were reviewed, and over 25,000 in-patients treat...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201034

    authors: Hart AR,Mann R,Mayberry JF

    更新日期:1993-01-01 00:00:00

  • Vitamin A status in 137 patients with Crohn's disease.

    abstract::Serum retinol and serum carotene concentrations were determined over a 6-month period in 137 outpatients with Crohn's disease. Serum retinol measurements were within the reference range for all patients at each assessment period, while serum carotene levels were low in about one quarter of the patients. Of the 56 pati...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199495

    authors: Imes S,Pinchbeck B,Dinwoodie A,Walker K,Thomson AB

    更新日期:1987-01-01 00:00:00

  • The cholecystokinin effect on human intestinal permeability: influence of chenodeoxycholic and ursodeoxycholic acid administration.

    abstract::The influence of CDCA and UDCA administration on human intestinal permeability to lactulose, as disclosed by intravenous CCK, has been investigated. For this purpose the fraction of lactulose excreted in the urine during 5 h after an oral load of the disaccharide in hypertonic solution was measured in 12 healthy subje...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198808

    authors: Budillon G,Parrilli G,Capuano G,Mazzacca G,Menzies IS

    更新日期:1982-01-01 00:00:00

  • Diagnostic value of serum ferritin in primary hepatocellular carcinoma.

    abstract::The diagnostic value of serum ferritin levels was evaluated in 19 patients with biopsy-proven primary hepatocellular carcinoma (PHC) and 26 patients with chronic liver disease (CLD). Serum ferritin levels were significantly elevated in PHC, as compared with CLD and controls (p less than 0.0005). Similarly, serum ferri...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199114

    authors: Giannoulis E,Arvanitakis C,Nikopoulos A,Doutsos I,Tourkantonis A

    更新日期:1984-01-01 00:00:00

  • Role of the ileocecal valve and site of intestinal resection in malabsorption after extensive small bowel resection.

    abstract::Intestinal absorption after extensive small bowel resections, for diseases other than Crohn's disease, was studied in 17 patients. When the ileocecal valve and the right colon were preserved, malabsorption was transient and moderate and had no prejudicial nutritional effect (fecal fat: 8.8 +/- 1.8 g/24 h in resections...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198220

    authors: Cosnes J,Gendre JP,Le Quintrec Y

    更新日期:1978-01-01 00:00:00

  • Metabolic Alterations in Celiac Disease Occurring after Following a Gluten-Free Diet.

    abstract:BACKGROUND AND AIM:Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000495749

    authors: Ciccone A,Gabrieli D,Cardinale R,Di Ruscio M,Vernia F,Stefanelli G,Necozione S,Melideo D,Viscido A,Frieri G,Latella G

    更新日期:2019-01-01 00:00:00

  • Guiding manometry probes into the human small bowel without X-ray: validation of a new technique.

    abstract:BACKGROUND:In order to perform small bowel manometry studies in man, the probes have to be guided through the upper gastrointestinal tract. This is usually controlled by fluoroscopy, but a method that allows to place the tubes without X-rays is obviously desirable. METHODS:A new method that controls tube placing by so...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000123841

    authors: V Schönfeld J

    更新日期:2008-01-01 00:00:00

  • A new simple immunoassay for detecting Helicobacter pylori infection: antigen in stool specimens.

    abstract:BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007691

    authors: Fanti L,Mezzi G,Cavallero A,Gesu G,Bonato C,Masci E

    更新日期:1999-09-01 00:00:00

  • Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients.

    abstract:BACKGROUND/AIMS:There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patien...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000326854

    authors: Kim JH,Kim SY,Jung ES,Jung SW,Koo JS,Kim JH,Yeon JE,Kwon SY,Lee SW,Byun KS,Lee CH

    更新日期:2011-01-01 00:00:00

  • Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma.

    abstract:BACKGROUND AND AIM:A recent basic study identified that Dicer is contained in exosomes derived from cancer cells and plays crucial roles in microRNA maturation and cancer development. Based on this novel basic concept, we analyzed the usefulness of serum exosomal Dicer as a diagnostic biomarker for gastrointestinal can...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000510993

    authors: Okuda Y,Shimura T,Iwasaki H,Katano T,Kitagawa M,Nishigaki R,Fukusada S,Natsume M,Tanaka M,Nishie H,Ozeki K,Yamada T,Kataoka H

    更新日期:2020-10-13 00:00:00