Abstract:
BACKGROUND/AIMS:Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHODS:A total of 91 patients who were diagnosed as having early gastric cancer were enrolled. We evaluated the gastritis status using scores for gastritis and atrophy, positivity of H. pylori infection, the prevalence rate of xanthomas, and the clinicopathological features of gastric cancer. RESULTS:Gastric xanthomas were observed in 72.5% of early gastric cancer cases. Scores for gastritis and atrophy were significantly higher in the xanthoma-positive group than those in the xanthoma-negative group. A higher prevalence of differentiated-type adenocarcinoma was found in the xanthoma-positive group. Among the cases with multiple gastric xanthomas, the prevalence of males was significantly higher than that of females. CONCLUSION:A high prevalence rate of gastric xanthomas in gastric cancer cases was shown. Xanthomas were highly associated with age, the severities of gastritis and atrophy, and differentiated-type adenocarcinoma. Regardless of the eradication of H. pylori, xanthomas may be useful predictive markers for the development of differentiated-type adenocarcinoma.
journal_name
Digestionjournal_title
Digestionauthors
Kitamura S,Muguruma N,Okamoto K,Tanahashi T,Fukuya A,Tanaka K,Fujimoto D,Kimura T,Miyamoto H,Bando Y,Takeuchi H,Shiba M,Takayama Tdoi
10.1159/000481346subject
Has Abstractpub_date
2017-11-01 00:00:00pages
199-206issue
4eissn
0012-2823issn
1421-9867pii
000481346journal_volume
96pub_type
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