Octreotide in the treatment of refractory diarrhea.

Abstract:

:Refractory chronic diarrhea that does not respond to specific antimicrobial therapy or standard unspecific medication may present a challenging and serious clinical problem. Octreotide is a candidate drug for the treatment of these patients as it inhibits gastrointestinal motility, pancreatic secretion and inhibits intestinal absorption. Only few mostly uncontrolled studies in small patient groups were published evaluating the efficacy of octreotide in the treatment of patients with chemotherapy-induced diarrhea, short-bowel syndrome, AIDS-associated diarrhea and other conditions with chronic diarrhea not responding to standard treatment. Most of these studies are not conclusive as they yielded either negative or controversial results. Octreotide may be tried in the treatment of refractory diarrhea, in particular AIDS-associated diarrhea if patients do not respond to conventional treatment strategies. Well-designed controlled trials in large patient groups are needed in order to define the place of octreotide in the treatment of patients with refractory diarrhea.

journal_name

Digestion

journal_title

Digestion

authors

Fried M

doi

10.1159/000051479

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

42-6

eissn

0012-2823

issn

1421-9867

pii

51479

journal_volume

60 Suppl 2

pub_type

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