Abstract:
:The form in which copper is bound in bile was studied in bile from patients with Wilson's disease, control subjects and rats. Bile was labelled with 64Cu. Sephadex column chromatography using gels G-200--G-10 showed a major 64Cu and protein peak of about 5,000 daltons and a minor peak of about 8,000 daltons. A high-molecular-weight peak (above 800,000 daltons) which was present when the eluting solution consisted of water or saline was shown to be an artefact which could be abolished by the addition of bile salt to the eluting solution. Bile from control subjects, Wilson's disease patients and from the rats behaved in the same manner binding copper to low-molecular-weight proteins. The relationship of these findings to the pathogenesis of copper retention in Wilson's disease is discussed.
journal_name
Digestionjournal_title
Digestionauthors
Frommer DJdoi
10.1159/000198027subject
Has Abstractpub_date
1977-01-01 00:00:00pages
390-6issue
5eissn
0012-2823issn
1421-9867journal_volume
15pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007691
更新日期:1999-09-01 00:00:00
abstract::Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197946
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND/AIMS:Some minimal changes (MCs) are believed to have a certain relationship with gastroesophageal reflux (GERD). Nonetheless, the individual meaning of MC is still unclear. Our aim was to compare the overall and individual prevalence of MC between patients with non-erosive reflux disease (NERD) and healthy c...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000337198
更新日期:2012-01-01 00:00:00
abstract::Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198444
更新日期:1980-01-01 00:00:00
abstract::The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199492
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051928
更新日期:2002-01-01 00:00:00
abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007815
更新日期:2000-01-01 00:00:00
abstract::Mortality data for ulcerative colitis, Crohn's disease, and unspecified inflammatory bowel disease were examined for the countries Venezuela, Italy, and France during the decade 1969-1978. These figures were compared with similar data from England and Wales obtained from 1965 to 1975. In Italy and France deaths from C...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199040
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND/AIMS:Only the depth of submucosal invasion can be estimated prior to determining the indications for endoscopic submucosal dissection (ESD) as a curative treatment for colorectal carcinoma (CRC). Here we evaluated the outcomes of ESD for clinical T1 CRCs. METHODS:Of 660 patients who underwent ESD for CRC at...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000368866
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM:To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS:Prepubertal children of ages 3-12 with either la...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000381895
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AND AIM:Sonic hedgehog (Shh) is a morphogen involved in the homeostasis of the gastric fundic glands. Alterations of gastric mucosal Shh expression after eradication of Helicobacter pylori were examined. METHOD:Mongolian gerbils were inoculated with H. pylori at the age of 5 weeks. H. pylori eradication was...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000209219
更新日期:2009-01-01 00:00:00
abstract::We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198753
更新日期:1982-01-01 00:00:00
abstract::In chronic pancreatitis the exocrine pancreatic tissue is replaced by extracellular matrix deposits from fibroblasts. We have stimulated fibrogenesis in the pancreas by inducing a single episode of cerulein pancreatitis (10 microg/kg/h for 12 h). We have used a spectrophotometrical assay to measure the tissue hydroxyp...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201423
更新日期:1997-01-01 00:00:00
abstract::Previous investigations have demonstrated that the cellular signaling induced by hypoxia-reoxygenation is a major pathway contributing to gastric mucosal injury induced by stress, non-steroidal anti-inflammatory drugs, and Helicobacter pylori. The aim of the present study was to perform a gene expression analysis of t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000094039
更新日期:2006-01-01 00:00:00
abstract::Saliva from one parotid gland was collected under citric acid stimulation in three groups consisting of 69 control subjects and two groups consisting of 25 patients with chronic and relapsing chronic pancreatitis. Mixed saliva was collected under mechanical stimulation from 10 patients and 6 control subjects. Flow rat...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198781
更新日期:1982-01-01 00:00:00
abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200869
更新日期:1992-01-01 00:00:00
abstract::The diagnostic value of serum ferritin levels was evaluated in 19 patients with biopsy-proven primary hepatocellular carcinoma (PHC) and 26 patients with chronic liver disease (CLD). Serum ferritin levels were significantly elevated in PHC, as compared with CLD and controls (p less than 0.0005). Similarly, serum ferri...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199114
更新日期:1984-01-01 00:00:00
abstract:INTRODUCTION:Autoimmune enteropathy (AIE) is a rare cause of intractable diarrhea in infancy. A variant with onset in adulthood has recently been described. The immune mechanisms underlying AIE are unclear and the experience in the management of adult AIE is very limited. CASE REPORT:A 19-year-old male patient with ma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000084648
更新日期:2005-01-01 00:00:00
abstract::Functional digestive disorders constitute one of the main causes of consultation in gastroenterology and primary health care. Is still unclear whether therapy has to be aimed to the gut, to the neural pathways controlling bowel motility and perception, or to the processing mechanisms of symptoms and disease behaviour....
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000089777
更新日期:2006-01-01 00:00:00
abstract::Rats were subjected to serial venesections 3 days prior to and then sequentially for 4 weeks after surgical removal of either the proximal or distal half of the small bowel. Total serum protein concentration and protein electrophoretic patterns were determined on these sera. Both sham-operated and unoperated animals s...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198408
更新日期:1980-01-01 00:00:00
abstract::The treatment of malignant neuroendocrine gut and pancreatic tumors provides a therapeutic challenge. Surgery as well as medical treatment rarely cure the patient at this stage. Symptoms related to secretory products from the tumor might be life-threatening or at least reduce the quality of life considerably. Interfer...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201204
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Capsule endoscopy (CE) has been recognised as an important investigational tool in the diagnosis of gastrointestinal disease. Studies have shown that CE can identify lesions in the upper gastrointestinal tract as well as in the small intestine. However, contrary to conventional oesophagogastroscopy ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000089959
更新日期:2005-01-01 00:00:00
abstract::Fundic mucosal extracts of the cat were examined by chromatography using DEAE-cellulose at pH 5.3. The peaks of proteolytic activity located by this method were shown to be heterogeneous on electrophoresis. By electrophoresis of individual homogenous chromatographic fractions 9 separate zones of proteolytic activity w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197919
更新日期:1976-01-01 00:00:00
abstract::Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198335
更新日期:1979-01-01 00:00:00
abstract::The aim of this study was to evaluate the serum behavior of human pancreas-specific protein/procarboxypeptidase B (hPASP/PCPB) in the early phases of acute pancreatitis, and to calculate its sensitivity and specificity in comparison with those of serum amylase and lipase in the diagnosis of this illness. Twenty-six ac...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201128
更新日期:1994-01-01 00:00:00
abstract::D-Galactosamine administration to rats (400 mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and 24 h after D-galactosamine injection. Plasma membrane 5'-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198373
更新日期:1979-01-01 00:00:00
abstract::Outpatient treatment of haemorrhoids by elastic band ligation without anaesthetic was performed in 75 patients. Clinical review showed that 65 returned to work within 24 h of ligation, 8 in 48 h and 2 after 48 h. No patient required hospitalisation for either rectal bleeding or pain after ligation. In the first week a...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197658
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:Combinations of antitumor necrosis factor alpha (TNFα) and immunomodulators may be indicated in high-risk inflammatory bowel disease patients. Our aims were to compare disease course between children that did and did not step down to anti-TNFα monotherapy and to define risk factors for complicated disease cou...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000496273
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:The changes in gastroesophageal reflux disease (GERD)-related symptoms on treatment are variously described, but currently available questionnaires have shortcomings. We therefore developed a self-assessment reflux questionnaire (ReQuest). This article describes the process of development and testing. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000101080
更新日期:2007-01-01 00:00:00
abstract::Serum antibodies directed against 5 alimentary antigens and antigen-antibody complexes were determined in 15 control subjects and in 15 patients with alcoholic liver cirrhosis. Cirrhotic patients presented an increased immune response against these antigens. Antigen-antibody complexes were detected in the fasting plas...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198162
更新日期:1978-01-01 00:00:00