Hepatic and intestinal elimination of endogenous gastrin in pigs.

abstract：:Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [1...

journal_title：Digestion

authors： Gehl J,Jeppesen JL,Poulsen SS,Holst JJ

更新日期：1988-01-01 00:00:00

abstract：:Hepatitis B surface antigen (HBsAg)-associated receptors for polymerized human serum albumin (RpHSA) are assumed to mediate viral attachment to hepatocytes in hepatitis B virus (HBV) infection. RpHSA was found to be coded by the pre-S region of HBV genome. Recently, the antiviral effect of recombinant leukocyte alpha-...

journal_title：Digestion

authors： Gerken G,Manns M,Hess G,Meyer zum Büschenfelde KH

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND/AIMS:Acotiamide, a prokinetic drug, is used to treat functional dyspepsia (FD), especially postprandial distress syndrome (PDS). However, a treatment for FD patients with PDS and/or epigastric pain syndrome (EPS) has not been established. We investigated the efficacy of famotidine in combination with acotiam...

journal_title：Digestion

authors： Hojo M,Nagahara A,Asaoka D,Takeda T,Izumi K,Matsumoto K,Ueyama H,Shimada Y,Matsumoto K,Nojiri S,Watanabe S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted...

journal_title：Digestion

authors： Shiga H,Takagi S,Inoue R,Kinouchi Y,Ohkubo T,Takahashi S,Negoro K,Yokoyama H,Kato S,Fukushima K,Hiwatashi N,Shimosegawa T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Double-filtration plasmapheresis (DFPP) together with interferon (IFN) administration produces a substantial reduction in the viral load during the early stages of treatment. METHODS:Based on their responses to previous pegylated IFN and ribavirin (PEG-IFN/RBV) therapy, 20 patients were divided int...

journal_title：Digestion

authors： Kim SR,Saito J,Imoto S,Komaki T,Nagata Y,Kim KI,Sasase N,Kimura N,Sasatani K,Konishi E,Hasegawa Y,Fujinami A,Ohta M,El-Shamy A,Tanaka Y,Sugano M,Sakashita M,Nakamura A,Tsuchida S,Makino T,Kawada T,Nakajima T,M

更新日期：2011-01-01 00:00:00

abstract：:The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

journal_title：Digestion

authors： Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

更新日期：1986-01-01 00:00:00

abstract：:The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...

journal_title：Digestion

authors： Eade OE,Maddison A,Leonard PJ,Wright R

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance. METHODS:In total, 166 consecutive patients with gastrointestinal symptoms mimicking hypolactasia admitted to the clin...

journal_title：Digestion

authors： Büning C,Genschel J,Jurga J,Fiedler T,Voderholzer W,Fiedler EM,Worm M,Weltrich R,Lochs H,Schmidt H,Ockenga J

更新日期：2005-01-01 00:00:00

abstract：:The aim of the present work was to examine in pigs the effect of a dietary supplementation with the flavor enhancer monosodium glutamate (MSG) on intestinal amino acid metabolism. For this purpose, pigs weighing 60 +/- 2 kg received a standard meal twice a day for 1 week, supplemented with either 10 g MSG per meal or,...

journal_title：Digestion

authors： Blachier F,Guihot-Joubrel G,Vaugelade P,Le Boucher J,Bernard F,Duée P,Cynober L

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...

journal_title：Digestion

authors： Corpe C,Sreenan S,Burant C

更新日期：2001-01-01 00:00:00

abstract：:Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...

journal_title：Digestion

authors： Yamauchi J,Sunamura M,Shibuya K,Takeda K,Kobari M,Matsuno S

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS:An expert international group using the modified Delphi technique examined the q...

journal_title：Digestion

authors： Modlin IM,Hunt RH,Malfertheiner P,Moayyedi P,Quigley EM,Tytgat GN,Tack J,Heading RC,Holtman G,Moss SF,Vevey NERD Consensus Group.

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIMS:At present, benefits of surgical resection and appropriate selection criteria in patients affected by both hepatic and pulmonary metastases of colorectal cancer (CRC) are under discussion. Our analysis focused on a surgical series of such patients and our final aim consisted in identifying potential pro...

journal_title：Digestion

authors： Zizzo M,Galeone C,Braglia L,Ugoletti L,Siciliani A,Nachira D,Margaritora S,Pedrazzoli C,Paci M,Lococo F

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach. METHODS:Suckling rats were prematurely weaned on postnatal day 15 and followed through...

journal_title：Digestion

authors： Lin CH,Lyons H,Seelbach MS,Tolia V,Vijesurier R

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is a functional bowel disorder which is characterized by abdominal pain and disturbed bowel habits. The pathophysiological mechanism is complex and still remains incompletely clear. Alterations at both the central and the peripheral level are thought to contribute to the sympto...

journal_title：Digestion

authors： Zhang H,Yan Y,Shi R,Lin Z,Wang M,Lin L

更新日期：2008-01-01 00:00:00

abstract：:A young Indian man presented in England with a 6-month history of diarrhoea which started just before leaving India. He was found to have tropical enteropathy and H. nana infestation, but while the infestation and symptoms disappeared with antihelminthic treatment, the tropical enteropathy persisted. Hymenolepiasis is...

journal_title：Digestion

authors： Cooper BT,Hodgson HJ,Chadwick VS

更新日期：1981-01-01 00:00:00

abstract：:We describe a patient with relapses of Clostridium difficile cytotoxin-positive pseudomembranous colitis (PMC) after treatment with vancomycin, a course of metronidazole and a trial of bacitracin. She remains free of disease after a prolonged course of cholestyramine. We suggest there may be a role for anion-exchange ...

journal_title：Digestion

authors： Kunimoto D,Thomson AB

更新日期：1986-01-01 00:00:00

abstract：:25 missionaries working in Taiwan, Thailand, Indonesia and the Philippines completed questionnaires regarding their clinical practice during the year 1980. Data were collected on the numbers of both gastric and colorectal cancers diagnosed. More than 90,000 out-patients were reviewed, and over 25,000 in-patients treat...

journal_title：Digestion

authors： Hart AR,Mann R,Mayberry JF

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIMS:Gallbladder mucus itself has been recognized to play an important role in gallstone development. Despite the diverse mechanisms of stone induction and the differences in stone composition, there is a quantitative increase in the epithelial mucus production period before stone formation. As brown pigment...

journal_title：Digestion

authors： Sheen PC,Lee KT,Liu YE

更新日期：1998-11-01 00:00:00

abstract：:The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...

journal_title：Digestion

authors： Takeuchi K,Johnson LR

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...

journal_title：Digestion

authors： Konturek PC,Jaworek J,Maniatoglou A,Bonior J,Meixner H,Konturek SJ,Hahn EG

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...

journal_title：Digestion

authors： Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

更新日期：2007-01-01 00:00:00

abstract：:Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...

journal_title：Digestion

authors： Pointner H,Kletter K

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:Recently, several studies have demonstrated the usefulness of endoscopic submucosal dissection (ESD) for residual or locally recurrent colorectal lesions after endoscopic treatment. However, the feasibility of ESD for recurrent rectal lesions after transanal endoscopic microsurgery (TEM) has not been fully i...

journal_title：Digestion

authors： Ikezawa N,Toyonaga T,Tanaka S,Nakano Y,Ishida T,Yoshihara T,Uraoka M,Morita Y,Suzuki N,Haji A,Kodama Y

更新日期：2020-02-05 00:00:00

abstract：BACKGROUND AND AIM:Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METH...

journal_title：Digestion

authors： Kotachi T,Ito M,Boda T,Kiso M,Masuda K,Hata K,Kawamura T,Sanomura Y,Yoshihara M,Tanaka S,Chayama K

更新日期：2018-01-01 00:00:00

abstract：:The core symposiums of the Japanese Gastroenterological Association (JGA) annual scientific meetings focus on similar topics from year to year. The main topics of these symposiums for the last 3 years were centered on progress in new diagnostics and therapeutic strategies for gastrointestinal malignancy, with a specia...

journal_title：Digestion

authors： Sugiyama T

更新日期：2015-01-01 00:00:00

abstract：:Chenodeoxycholic acid (CDCA) is an effective treatment for dissolving gallstones but experimental studies have suggested that it might be hepatotoxic. The present study is concerned with a group of patients undergoing medical therapy for gallstones for periods of 30 days up to 14 months with CDCA (15 mg/kg/day). Routi...

journal_title：Digestion

authors： Koch MM,Giampieri MP,Lorenzini I,Jezequel AM,Orlandi F

更新日期：1980-01-01 00:00:00

abstract：:Chemiluminescence (CL) is a simple quantitative assay of polymorphonuclear leucocyte (PMNL) oxidative metabolism. PMNL CL was found to be significantly higher in patients with chronic inflammatory bowel disease than in normal controls (167 +/- 60 vs. 139 +/- 50 mV/10(5) cells, p less than 0.05). There were no signific...

journal_title：Digestion

authors： Kelleher D,Feighery C,Weir DG

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:The exact etiology of irritable bowel syndrome (IBS) remains unclear. Curative treatment is not available and current treatment modalities are mainly directed against the predominant symptoms. There are a few studies reporting the beneficial effects of transcutaneous electrical stimulation in patients with c...

journal_title：Digestion

authors： Coban Ş,Akbal E,Köklü S,Köklü G,Ulaşlı MA,Erkeç S,Aktaş B,Yüksel O,Koçak E,Erdem HR

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy for advanced gastric cancer is expected to improve prognoses. However, as there is no method to evaluate neoadjuvant chemotherapeutic efficacy before gastrectomy, some patients at high risk for a poor prognosis undergo gastrectomy. The aim of the present study was to investigate whet...

journal_title：Digestion

authors： Sugawara N,Ota K,Terazawa T,Tanaka R,Akutagawa H,Yamaguchi T,Imai Y,Harada S,Kojima Y,Tashiro K,Kii T,Lee SW,Kawai M,Egashira Y,Goto M,Uchiyama K,Hirose Y,Takeuchi T,Higuchi K

更新日期：2020-01-01 00:00:00