Phospholipase A2 activity of colonic mucosa in patients with ulcerative colitis.

Abstract:

:Activation of enzyme phospholipase A2 (EC 3.1.1.4), the major liberator of arachidonic acid, has been proposed as a component in the pathogenesis of inflammatory bowel disease. To test the hypothesis that phospholipase A2 activity is increased in ulcerative colitis, enzyme activity was investigated in colonic biopsies using radiolabelled Escherichia coli as substrate. The study comprised patients with ulcerative colitis (n = 19) and controls without inflammatory bowel disease (n = 7). Ulcerative colitis patients were grouped into those with active disease (n = 8) and those in remission (n = 11) at the time of colonoscopy. No differences were found in mucosal phospholipase A2 activity between patients with active disease, patients in remission and controls. With the present assay we were unable to demonstrate activation of phospholipase A2 as a mechanism in the inflammatory process of ulcerative colitis.

journal_name

Digestion

journal_title

Digestion

authors

Almer S,Franzén L,Olaison G,Smedh K,Ström M

doi

10.1159/000200753

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

135-41

issue

3-4

eissn

0012-2823

issn

1421-9867

journal_volume

50

pub_type

杂志文章
  • Effect of filtrate containing Clostridium difficile toxin on rectal mucosa maintained in organ culture.

    abstract::Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199212

    authors: Allan A,Jewell DP

    更新日期:1985-01-01 00:00:00

  • Effect of fasting and refeeding on basolateral polyamine uptake and metabolism by the rat small bowel.

    abstract::Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200737

    authors: Bardócz S,Grant G,Brown DS,Ewen SW,Stewart JC,Pusztai A

    更新日期:1991-01-01 00:00:00

  • Is the 14C-triolein breath test useful in the assessment of malabsorption in clinical practice?

    abstract::A 14C-triolein breath test was carried out on 49 subjects suffering from chronic pancreatitis or from other digestive diseases, and its results were compared with the daily fecal fat excretion. The 14CO2 peak excretion was abnormal in all the subjects with a fecal fat excretion above 14 g/day, whereas individual value...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199015

    authors: Benini L,Scuro LA,Menini E,Manfrini C,Vantini I,Vaona B,Brocco G,Talamini G,Cavallini G

    更新日期:1984-01-01 00:00:00

  • Short bowel syndrome.

    abstract::Nine patients with short bowel syndrome and high intestinal output received octreotide either intravenously (50-100 micrograms t.i.d.) or subcutaneously (100 micrograms b.i.d.) on 2 test days. In the 6 patients with net secretory output, there was a reduction in mean daily intestinal output of 0.5-5.0 kg; total daily ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200267

    authors: Nightingale JM,Walker ER,Burnham WR,Farthing MJ,Lennard-Jones JE

    更新日期:1990-01-01 00:00:00

  • Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients.

    abstract:BACKGROUND/AIMS:There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patien...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000326854

    authors: Kim JH,Kim SY,Jung ES,Jung SW,Koo JS,Kim JH,Yeon JE,Kwon SY,Lee SW,Byun KS,Lee CH

    更新日期:2011-01-01 00:00:00

  • Defective inhibition of gastrin release by antral distension in duodenal ulcer patients.

    abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200869

    authors: Sjövall M,Lindstedt G,Olbe L,Lundell L

    更新日期:1992-01-01 00:00:00

  • Feasibility and Safety of Endoscopic Submucosal Dissection for Recurrent Rectal Lesions that after Transanal Endoscopic Microsurgery: A Case Series.

    abstract:OBJECTIVES:Recently, several studies have demonstrated the usefulness of endoscopic submucosal dissection (ESD) for residual or locally recurrent colorectal lesions after endoscopic treatment. However, the feasibility of ESD for recurrent rectal lesions after transanal endoscopic microsurgery (TEM) has not been fully i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000505619

    authors: Ikezawa N,Toyonaga T,Tanaka S,Nakano Y,Ishida T,Yoshihara T,Uraoka M,Morita Y,Suzuki N,Haji A,Kodama Y

    更新日期:2020-02-05 00:00:00

  • Functional renal alterations in chronic liver diseases.

    abstract::83 patients with chronic active hepatitis (CAH), 38 of them with cirrhosis, were studied and compared with 10 control subjects suffering from chronic persistent hepatitis (CPH). Tubular acidosis frequently was found in our cases. Renal plasma flow and glomerular filtration rate were significantly decreased in CAH when...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198421

    authors: Gentilini P,Laffi G,Buzzelli G,Stefani P,Scarpelli P,Paladini S,Smorlesi C,La Villa G,Forti G

    更新日期:1980-01-01 00:00:00

  • True adenomas of the cardia: a case series of 3 patients.

    abstract:BACKGROUND/AIM:True adenomas of the cardia appear to be extremely rare lesions. There are no data on the natural history and histopathological background of these lesions. We report 3 patients with true adenomas of the cardia. METHODS AND RESULTS:Three patients with polypoid masses at the cardia below the Z-line were ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000121413

    authors: Bajbouj M,von Weyhern C,Becker V,Seidl S,Ott R,Schatke W,Fend F,Schmid RM,Meining A

    更新日期:2008-01-01 00:00:00

  • Chromoendoscopy is a valuable tool for screening of high-risk patients with head and neck cancer for early detection of esophageal cancer.

    abstract:BACKGROUND:The incidence of esophageal cancer is markedly increased in patients with head and neck cancer, and the presence of esophageal cancer is associated with reduced survival rates. AIMS:We investigated whether the results of screening for esophageal cancer in patients with head and neck cancer using chromoendos...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000094523

    authors: Moschler O,Spahn TW,Middelberg-Bisping C,Grosse-Thie W,Christoph B,Kloeppel G,Mueller MK

    更新日期:2006-01-01 00:00:00

  • Effect of food intake on circulating antigen-antibody complexes in patients with alcoholic liver cirrhosis.

    abstract::Serum antibodies directed against 5 alimentary antigens and antigen-antibody complexes were determined in 15 control subjects and in 15 patients with alcoholic liver cirrhosis. Cirrhotic patients presented an increased immune response against these antigens. Antigen-antibody complexes were detected in the fasting plas...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198162

    authors: André F,Druguet M,André C

    更新日期:1978-01-01 00:00:00

  • Investigation of genome instability in exfoliated colonic epithelial cells and in mitogen-stimulated lymphocytes of patients with ulcerative colitis.

    abstract:OBJECTIVE:The present study aimed to evaluate the micronucleus (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in the mitogen-stimulated lymphocytes of patients with ulcerative colitis (UC). In addition, we assessed MN frequency in exfoliated colonic epithelial cells obtained from both the diseased and heal...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000336358

    authors: Karaman A,Hamurcu Z,Donmez H,Bitken N,Karaman H,Baskol M,Gursoy S,Guven K,Ozbakir O,Yucesoy M

    更新日期:2012-01-01 00:00:00

  • Effect of fasting on diarrhoea in collagenous colitis.

    abstract:BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051928

    authors: Bohr J,Järnerot G,Tysk C,Jones I,Eriksson S

    更新日期:2002-01-01 00:00:00

  • A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan.

    abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000507570

    authors: Kudo T,Fujii T,Maisawa SI,Sasaki M,Uchida K,Ida S,Kagimoto S,Yoden A,Shimizu T

    更新日期:2020-05-18 00:00:00

  • Importance of plasma aldosterone concentration on the natriuretic effect of spironolactone in patients with liver cirrhosis and ascites.

    abstract::23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199198

    authors: Bernardi M,Servadei D,Trevisani F,Rusticali AG,Gasbarrini G

    更新日期:1985-01-01 00:00:00

  • Plasma lactate and urate concentrations following oral fructose in patients with liver disease.

    abstract::Plasma lactate and urate concentrations, following 50 g oral fructose, were compared in 12 control subjects and 13 patients with liver disease. No serious adverse effects occurred following fructose ingestion, and in neither group did the plasma lactate concentration exceed 5.2 mmol/l. There were no significant differ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198843

    authors: Douglas JG,Beckett GJ

    更新日期:1982-01-01 00:00:00

  • The Ameliorating Effect of Lactobacillus gasseri OLL2716 on Functional Dyspepsia in Helicobacter pylori-Uninfected Individuals: A Randomized Controlled Study.

    abstract:BACKGROUND/AIMS:Probiotics appear to improve Helicobacter pylori-associated dyspepsia via an inhibitory effect on H. pylori; however, uncertainty exists regarding their effects in H. pylori-uninfected individuals. We evaluated the efficacy of Lactobacillus gasseri OLL2716 (L. gasseri OLL2716) on H. pylori-uninfected in...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000479000

    authors: Ohtsu T,Takagi A,Uemura N,Inoue K,Sekino H,Kawashima A,Uchida M,Koga Y

    更新日期:2017-01-01 00:00:00

  • Polyamine uptake across the basolateral membrane of the enterocyte is mediated by a high-affinity carrier: a study using isolated basolateral membrane vesicles.

    abstract:BACKGROUND/AIMS:Polyamine uptake from the circulation plays an important role in the maintenance of the intracellular polyamine content during extensive proliferation in intestinal mucosal cells. METHODS:Isolated basolateral membrane vesicles of the rabbit enterocyte were used to characterize polyamine transport acros...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007468

    authors: Milovic V,Caspary WF,Stein J

    更新日期:1998-01-01 00:00:00

  • Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related chronic gastritis.

    abstract::Combining the narrow-band imaging (NBI) system and magnifying endoscopy allows simple and clear visualization of microscopic structures of the superficial mucosa and its capillary patterns, which may be useful for precise endoscopic diagnosis in the gastrointestinal tract, being more closely to histopathological diagn...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000321799

    authors: Okubo M,Tahara T,Shibata T,Nakamura M,Kamiya Y,Yoshioka D,Maeda Y,Yonemura J,Ishizuka T,Arisawa T,Hirata I

    更新日期:2011-01-01 00:00:00

  • Effect of gastrin receptor antagonists on gastric acid secretion and gastrin and somatostatin release in the rat stomach.

    abstract::The effects of two recently developed gastrin receptor antagonists, PD 136450 and L-365,260, on pentagastrin-stimulated acid secretion were investigated in rats. PD 136450 at a dose of 6 mg/kg s.c. (9.6 mumol) completely abolished acid secretion induced by pentagastrin. The inhibition of 18 mg/kg PD 136450 s.c. lasted...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200993

    authors: Eissele R,Koop H,Bothe-Sandfort E,Arnold R

    更新日期:1992-01-01 00:00:00

  • Non-steroidal anti-inflammatory drugs inhibit the processes of mucosal cell proliferation associated with duodenal ulcer healing.

    abstract::We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection technique was used to quantitate mitosis in duodenal crypts at the ulcer edge, giving a regeneration ind...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200987

    authors: Levi S,Goodlad RA,Lee CY,Stamp G,Walport MJ,Wright NA,Hodgson HJ

    更新日期:1992-01-01 00:00:00

  • Induction of gastric ornithine decarboxylase in early weaning rats.

    abstract:BACKGROUND/AIMS:Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach. METHODS:Suckling rats were prematurely weaned on postnatal day 15 and followed through...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051892

    authors: Lin CH,Lyons H,Seelbach MS,Tolia V,Vijesurier R

    更新日期:2001-01-01 00:00:00

  • Hesperidin Improves Colonic Motility in Loeramide-Induced Constipation Rat Model via 5-Hydroxytryptamine 4R/cAMP Signaling Pathway.

    abstract::Fructus has motivation effect on gastrointestinal tract. Hesperidin is extracts of Fructus, and we attempted to prove its effects on improving the gastrointestinal transmission function and determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. Constipation phenotypes were mea...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000501959

    authors: Wu M,Li Y,Gu Y

    更新日期:2020-01-01 00:00:00

  • Plasmapheresis in Crohn's disease.

    abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198344

    authors: Holdstock GE,Fisher JA,Hamblin TJ,Loehry C

    更新日期:1979-01-01 00:00:00

  • Diagnostic value of serum ferritin in primary hepatocellular carcinoma.

    abstract::The diagnostic value of serum ferritin levels was evaluated in 19 patients with biopsy-proven primary hepatocellular carcinoma (PHC) and 26 patients with chronic liver disease (CLD). Serum ferritin levels were significantly elevated in PHC, as compared with CLD and controls (p less than 0.0005). Similarly, serum ferri...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199114

    authors: Giannoulis E,Arvanitakis C,Nikopoulos A,Doutsos I,Tourkantonis A

    更新日期:1984-01-01 00:00:00

  • Effects of n-3 polyunsaturated fatty acids and vitamin E on colonic mucosal leukotriene generation, lipid peroxidation, and microcirculation in rats with experimental colitis.

    abstract:AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051872

    authors: Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

    更新日期:2001-01-01 00:00:00

  • Two common reasons of malabsorption syndromes: celiac disease and Whipple's disease.

    abstract::Malabsorption syndromes are commonly caused by pathological interferences of normal digestive processes. In the last several years major advances in the diagnosis and treatment of these syndromes has emerged. This review will focus on diseases in which the mucosal phase of the digestive process is predominately distur...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000100501

    authors: Sun DF,Fang JY

    更新日期:2006-01-01 00:00:00

  • Unnecessary Procedures and Surgery in Autoimmune Pancreatitis.

    abstract:BACKGROUND/AIMS:To identify the number and potential causes of unnecessary diagnostic procedures in a cohort of patients with autoimmune pancreatitis (AIP). METHODS:All AIP cases at our centre between April 2006 and April 2013 were collected and followed up. Diagnosis was established by the International Consensus Dia...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000437259

    authors: Manser CN,Gubler C,Müllhaupt B,Bauerfeind P

    更新日期:2015-01-01 00:00:00

  • Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome.

    abstract:BACKGROUND AND AIMS:Validity of the lactulose breath test (LBT) to diagnose small intestinal bacterial overgrowth (SIBO) has been questioned. Therefore, a study was planned to compare LBT with glucose breath test (GBT) to diagnose SIBO in irritable bowel syndrome (IBS) patients and controls. METHODS:175 diarrhea-predo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000336174

    authors: Rana SV,Sharma S,Kaur J,Sinha SK,Singh K

    更新日期:2012-01-01 00:00:00

  • Effect of Helicobacter pylori infection on the activity of class I, III and IV alcohol dehydrogenase in the human stomach.

    abstract:BACKGROUND/AIMS:In the human stomach various alcohol dehydrogenase (ADH) isoenzymes exist. The gastric ADH activity is affected by a number of factors including also the infection of Helicobacter pylori. The objective was to investigate the activity of alcohol dehydrogenase isoenzymes of class I, III and IV in endoscop...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000064416

    authors: Chrostek L,Jelski W,Szmitkowski M,Laszewicz W

    更新日期:2002-01-01 00:00:00