Intracellular mechanism responsible for reduced enzyme secretion from camostate-induced hypertrophied pancreas.

abstract：:Recently our studies have demonstrated that the central nervous system regulates in part mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase (ODC) activity is a key enzyme for polyamine synthesis which plays an important role for the intestinal mucosal growth. We have demonstrated tha...

journal_title：Digestion

authors： Fujimoto K,Iwakiri R,Utsumi H,Kojima M,Ishibashi S,Wu B,Sakata H,Noda T

更新日期：2001-01-01 00:00:00

abstract：:Gastric emptying was measured in 12 patients with chronic duodenal ulceration and compared with the results from 10 healthy volunteers. The test meal of 300 ml 15% dextrose, labelled with 99mTc-DTPA, was ingested in increments over 6 min. Gamma camera imaging proceeded over 30 min, with a 1-min frame time. A direct co...

journal_title：Digestion

authors： Parr NJ,Grime S,Critchley M,Baxter JN,Mackie CR

更新日期：1988-01-01 00:00:00

abstract：AIMS:Evaluating the accuracy of the modified Endoscopic ABC (Endo ABC) classification with an electronic endoscopy with narrow band imaging without magnification in diagnosing Helicobacter pylori (H. pylori)-infected gastritis. METHODS:A total of 576 patients were enrolled and they underwent modified Endo ABC. They we...

journal_title：Digestion

authors： Inui M,Ohwada S,Inui Y,Kondo Y,Moro A,Sasaki K

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:This study aimed to analyze the endoscopic mucosal resection (EMR) with a novel uniquely shaped, double-loop snare (Dualoop, Medico's Hirata Inc., Tokyo, Japan) for colorectal polyps. METHODS:This was a clinical trial conducted in two referral centers, Kyoto Prefectural University of Medicine and Natio...

journal_title：Digestion

authors： Yoshida N,Saito Y,Hirose R,Ogiso K,Inada Y,Yagi N,Naito Y,Otake Y,Nakajima T,Matsuda T,Yanagisawa A,Itoh Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) is recognized as a minimally invasive and curative treatment for superficial gastrointestinal (GI) cancers. However, ESD is still challenging and time-consuming with a high risk of adverse events such as bleeding and perforation. Various traction methods have been explo...

journal_title：Digestion

authors： Kaku H,Toyonaga T,Tanaka S,Takihara H,Baba S,Tsubouchi E,Ikeda Y,Orita H,Nakamoto M,Horikawa Y,Chiba H,Ban H,Furumoto Y,Morita R,Kodama Y

更新日期：2020-12-22 00:00:00

abstract：:Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine which modifies tissue stromal matrix synthesis, cell proliferation and immune function. In the present study, we have used a mouse monoclonal antibody to the latent (intracytoplasmic) form of TGF-beta 1 to compare its expression in 144 cases ...

journal_title：Digestion

authors： Slater SD,Williamson RC,Foster CS

更新日期：1995-01-01 00:00:00

abstract：AIM:To determine the long-term effect of argon plasma coagulation (APC) of gastric inlet patches in the cervical esophagus for patients suffering from globus sensation. METHODS:We intended to follow up all patients between 2004 and 2011 (n = 49) who received argon plasma ablation of gastric inlet patches for globus se...

journal_title：Digestion

authors： Klare P,Meining A,von Delius S,Wolf P,Konukiewitz B,Schmid RM,Bajbouj M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...

journal_title：Digestion

authors： Bohr J,Järnerot G,Tysk C,Jones I,Eriksson S

更新日期：2002-01-01 00:00:00

abstract：:We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...

journal_title：Digestion

authors： Ahlman H

更新日期：1996-01-01 00:00:00

abstract：:The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics. We analyzed its effect on the entero-insular axis in 72 healthy volunteers in a double-blind study design before, after the 1st dose, and on the 7th day of a 7-day treat...

journal_title：Digestion

authors： Göke B,Fuder H,Wieckhorst G,Theiss U,Stridde E,Littke T,Kleist P,Arnold R,Lücker PW

更新日期：1995-01-01 00:00:00

abstract：:The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

journal_title：Digestion

authors： Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

更新日期：1986-01-01 00:00:00

abstract：:The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 ...

journal_title：Digestion

authors： Wereszczyńska-Siemiatkowska U,Pohl U,Otto J,Lankisch PG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Westernization, above all associated changes in diet, has been postulated to be one of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn's disease and ulcerative colitis. SUMMARY:Diet represents a crucially important and intui...

journal_title：Digestion

authors： Schreiner P,Martinho-Grueber M,Studerus D,Vavricka SR,Tilg H,Biedermann L,on behalf of Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIM:Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients...

journal_title：Digestion

authors： Ciccone A,Gabrieli D,Cardinale R,Di Ruscio M,Vernia F,Stefanelli G,Necozione S,Melideo D,Viscido A,Frieri G,Latella G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies (IMT). However, the underlying UC remained active in some UC patients, despite the fact that CMV-DNA in colonic mucosa became negative after antiviral therapy. Therefore, new therapeutic strategies f...

journal_title：Digestion

authors： Yoshino T,Nakase H,Matsuura M,Matsumura K,Honzawa Y,Fukuchi T,Watanabe K,Murano M,Tsujikawa T,Fukunaga K,Matsumoto T,Chiba T

更新日期：2011-01-01 00:00:00

abstract：:Daily faecal calcium and magnesium outputs were inversely related to food-stimulated colonic intraluminal pressure in diverticular disease subjects. There was no relationship to sodium potassium and bile acid concentrations, nor to intestinal transit. ...

journal_title：Digestion

authors： Eastwood MA,Smith AN,Mitchell WD,Pritchard JL

更新日期：1980-01-01 00:00:00

abstract：:Electroencephalographic tracings of 50 patients with ulcerative colitis (UC) were compared with those of 75 controls. In the UC patients a 24% incidence of abnormal tracings was found as compared with an 8% incidence in the controls. A higher incidence of abnormal electroencephalograms was found among active cases of ...

journal_title：Digestion

authors： Eschar J,Arlazoroff A,Kleinhaus M,Mera A,Gilat T,Weissman I

更新日期：1975-01-01 00:00:00

abstract：:83 patients with chronic active hepatitis (CAH), 38 of them with cirrhosis, were studied and compared with 10 control subjects suffering from chronic persistent hepatitis (CPH). Tubular acidosis frequently was found in our cases. Renal plasma flow and glomerular filtration rate were significantly decreased in CAH when...

journal_title：Digestion

authors： Gentilini P,Laffi G,Buzzelli G,Stefani P,Scarpelli P,Paladini S,Smorlesi C,La Villa G,Forti G

更新日期：1980-01-01 00:00:00

abstract：:Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was ass...

journal_title：Digestion

authors： Weaver GA,Franck CA,Harris MD,Peters T Jr

更新日期：1991-01-01 00:00:00

abstract：:Isolated acinar cells from rat pancreas responded well to hormonal treatment. Both secretin (synthetic and highly purified from porcine origin) and CCK-octapeptide stimulated amylase secretion in these cells. The response in both cases was very rapid. A maximal output of enzyme was reached within 5-10 min after the ad...

journal_title：Digestion

authors： Lee PC

更新日期：1979-01-01 00:00:00

abstract：:The elimination of endogenous carboxyamidated and glycine-extended gastrins in liver and gut was studied before and after feeding in 14 anesthetized pigs. Before the meal, liver and gut extractions were nonsignificant. After feeding, the release rate of amidated gastrin increased from 7.5 +/- 2.6 to 21.9 +/- 5.3 pmol/...

journal_title：Digestion

authors： Hansen CP,Stadil F,Rehfeld JF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Intravenous iron and erythropoietin have been shown to be effective in Crohn's disease-associated anemia. The aim of this study was to test the sequential treatment of anemia in ulcerative colitis with intravenous iron in the first phase and erythropoietin in the second. PATIENTS AND METHODS:Twenty patients...

journal_title：Digestion

authors： Gasche C,Dejaco C,Reinisch W,Tillinger W,Waldhoer T,Fueger GF,Lochs H,Gangl A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Colorectal cancer (CRC) patients are at high risk for developing extracolorectal malignancies (EMs). Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not be...

journal_title：Digestion

authors： Kawai K,Ishihara S,Nozawa H,Hata K,Kiyomatsu T,Tanaka T,Nishikawa T,Otani K,Yasuda K,Murono K,Sasaki K,Watanabe T

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethano...

journal_title：Digestion

authors： Konturek SJ,Robert A

更新日期：1982-01-01 00:00:00

abstract：:The activity of platelet-activating factor (PAF) acetylhydrolase in biopsy specimens of intestinal mucosa was compared in patients with Crohn's disease (n = 11) and controls (n = 6). In addition, PAF acetylhydrolase activity was determined in the plasma of Crohn patients (n = 30) and healthy subjects (n = 35). The act...

journal_title：Digestion

authors： Kald B,Smedh K,Olaison G,Sjödahl R,Tagesson C

更新日期：1996-11-01 00:00:00

abstract：:We studied the functional coupling between antral somatostatin and gastrin cells in pigs using isolated perfused preparations of the antrum with intact supply of the vagus nerves. Luminal acidification significantly inhibited gastrin secretion to 61 +/- 3% of basal secretion and increased somatostatin output 9-fold. I...

journal_title：Digestion

authors： Holst JJ,Orskov C,Seier-Poulsen S

更新日期：1992-01-01 00:00:00

abstract：:At 1 year after a first resection, up to 80% of patients show an endoscopic recurrence, 10-20% have clinical relapse, and 5% have surgical recurrence. Smoking is one of the most important risk factors for postoperative recurrence. Preoperative disease activity and the severity of endoscopic lesions in the neoterminal ...

journal_title：Digestion

authors： Froehlich F,Juillerat P,Felley C,Mottet C,Vader JP,Burnand B,Michetti P,Gonvers JJ

更新日期：2005-01-01 00:00:00

abstract：:This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...

journal_title：Digestion

authors： Konturek SJ,Brzozowski T,Piastucki I,Radecki T

更新日期：1983-01-01 00:00:00

abstract：:Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient and the provider. The American Society of Anesthesiologists h...

journal_title：Digestion

authors： Paspatis GA,Tribonias G,Paraskeva K

更新日期：2010-01-01 00:00:00

abstract：:This study was undertaken to evaluate the effect of metoclopramide on transmural oesophageal variceal pressure and portal blood flow in cirrhotic patients. Sixteen cirrhotics were randomly assigned to metoclopramide (10 mg i.v.) or saline. Metoclopramide significantly decreased transmural variceal pressure (15.7% decr...

journal_title：Digestion

authors： Taranto D,Suozzo R,de Sio I,Romano M,Caporaso N,Del Vecchio Blanco C,Coltorti M

更新日期：1990-01-01 00:00:00