Abstract:
:The serine protease inhibitor camostate (Foy-305; 200 mg/kg body weight) had been administered twice daily either subcutaneously or orally to mice for 5, 10 and 15 days. Within 5 days, pancreatic weight, concentration of trypsin, amylase and protein were significantly increased and even more increased after 10 and 15 days. This effect is less pronounced after subcutaneous administration in comparison to oral treatment.
journal_name
Digestionjournal_title
Digestionauthors
Wereszczyńska-Siemiatkowska U,Pohl U,Otto J,Lankisch PGdoi
10.1159/000199491subject
Has Abstractpub_date
1987-01-01 00:00:00pages
144-8issue
3eissn
0012-2823issn
1421-9867journal_volume
37pub_type
杂志文章相关文献
DIGESTION文献大全abstract::The aim of the study was to define the effects of sex, age, smoking, alcohol, analgesic ingestion, and treatment method whereby healing was initially induced on the prognosis of patients with a chronic duodenal ulcer (DU). 122 patients were assessed 1 year after the endoscopic demonstration of a DU. Two outcome variab...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199171
更新日期:1985-01-01 00:00:00
abstract::A method of obtaining linear plots of protein-flow data from human pancreatic ductal secretions is described. The protein concentration in pancreatic secretions, when related to flow rates in two individuals, gave similar regression lines, with the correlation coefficients or r = -0.97 and -0.98, respectively, and slo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197922
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND/AIMS:We have used the Zucker diabetic fatty (ZDF) rat to study the effects of type-2 diabetes and troglitazone on the small intestinal mucosal mass, sugar transporters and the peroxisomal proliferator-activated receptor, PPAR-gamma. METHODS:Age-matched ZDF and lean control (ZLC) rats were fed a standard cho...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051879
更新日期:2001-01-01 00:00:00
abstract::Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient and the provider. The American Society of Anesthesiologists h...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000285504
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Current treatment strategies of variceal bleeding (VB) include banding and sclerotherapy. However, up to 10% of bleeding events remain refractory to standard therapy with high mortality. With this study, we aimed to evaluate the implantation of self-expanding metal stents (SEMS) for the management o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000335081
更新日期:2012-01-01 00:00:00
abstract::The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000200231
更新日期:1990-01-01 00:00:00
abstract::Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199226
更新日期:1985-01-01 00:00:00
abstract::The form in which copper is bound in bile was studied in bile from patients with Wilson's disease, control subjects and rats. Bile was labelled with 64Cu. Sephadex column chromatography using gels G-200--G-10 showed a major 64Cu and protein peak of about 5,000 daltons and a minor peak of about 8,000 daltons. A high-mo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198027
更新日期:1977-01-01 00:00:00
abstract::Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000007532
更新日期:1998-08-01 00:00:00
abstract::Functional changes of the exocrine pancreas in cerulein-induced pancreatitis were evaluated with the isolated perfused rat pancreas. In control specimens (n = 7), baseline pancreatic juice volume was 0.23 +/- 0.06 microliter/min and after stimulation with CCK-8 (10(-10) M) and secretin (10(-10) M), it was 2.26 +/- 0.4...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200879
更新日期:1992-01-01 00:00:00
abstract::Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200737
更新日期:1991-01-01 00:00:00
abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007815
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Human colorectal neuroendocrine cell carcinoma (NEC) is a rare disease with a poor prognosis. The biological behavior of NEC remains poorly understood. MATERIALS AND METHODS:We established two new NEC cell lines from a patient with rectal neuroendocrine carcinoma, NECS-P and NECS-L from the primary tumor an...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007825
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The safety of carbon dioxide (CO(2)) insufflation has not been fully established for esophageal and gastric endoscopic submucosal dissection (ESD) under deep sedation, because CO(2) retention is not only caused by CO(2) insufflation but also by the sedation level and the patient's respiratory status...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000328694
更新日期:2011-01-01 00:00:00
abstract::Omeprazole is a very potent and long-acting inhibitor of gastric acid secretion. These characteristics make the drug very suitable for the management of gastric acid hypersecretion and symptom relief in patients with the Zollinger-Ellison syndrome, and in the treatment of patients with ulcers resistant to histamine H2...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200102
更新日期:1989-01-01 00:00:00
abstract::The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201168
更新日期:1994-01-01 00:00:00
abstract::N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine HCl (DPPE) is an antihistamine with a unique profile of activity in the stomach. It is antisecretory and blocks the formation of experimental cold/stress- and ethanol-induced gastric lesions, as well as cysteamine-induced duodenal ulcers in a fashion more potent than o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200489
更新日期:1990-01-01 00:00:00
abstract::This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198975
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIMS:Gastric cancers are characterized by a heterogeneously hypoxic environment. Hypoxia might stimulate the malignant potential of cancer cells. The purpose of our study was to clarify the significance of hypoxia in gastric carcinoma by evaluating the expression of a hypoxic marker, namely carbonic anhydras...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000297208
更新日期:2010-01-01 00:00:00
abstract::Pancreatoduodenectomy (PD) may be followed by serious complications chiefly associated with exocrine pancreatic secretion. Somatostatin and its analogues are able to inhibit pancreatic secretion and thus have been advocated for the prevention of complications following pancreatic surgery. In four published multicentri...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000051490
更新日期:1999-01-01 00:00:00
abstract::In 1905, John Edkins (1863-1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive pharmacological agents that have revolutionized the management of acid pept...
journal_title:Digestion
pub_type: 传,历史文章,杂志文章
doi:10.1159/000088368
更新日期:2005-01-01 00:00:00
abstract::We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201406
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND/AIM:True adenomas of the cardia appear to be extremely rare lesions. There are no data on the natural history and histopathological background of these lesions. We report 3 patients with true adenomas of the cardia. METHODS AND RESULTS:Three patients with polypoid masses at the cardia below the Z-line were ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000121413
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND AIMS:There are limited data concerning the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) after double-balloon endoscopy (DBE). The aim of the present study was to evaluate the long-term outcome of patients with OGIB after DBE. PATIENTS AND METHODS:Eighty-seven consecutive pa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000313360
更新日期:2010-01-01 00:00:00
abstract::Previous investigations have demonstrated that the cellular signaling induced by hypoxia-reoxygenation is a major pathway contributing to gastric mucosal injury induced by stress, non-steroidal anti-inflammatory drugs, and Helicobacter pylori. The aim of the present study was to perform a gene expression analysis of t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000094039
更新日期:2006-01-01 00:00:00
abstract::L-Amino acid solution given intravenously in Heidenhain pouch dogs resulted in marked changes of both basal and pentagastrin-stimulated gastric secretions. During a 1-hour amino acid infusion, a significant augmentation of pentagastrin-induced secretion was observed. A significant increase of secretion during amino ac...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198207
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND/AIM:Cutaneous electrical stimulation has been reported to be as effective as electroacupuncture. The aim of this study was to test whether cutaneous electrical stimulation had the same effect as electroacupuncture to enhance the regularity of myoelectrical activity. METHODS:Fifteen healthy male volunteers w...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000065596
更新日期:2002-01-01 00:00:00
abstract::Plasma lactate and urate concentrations, following 50 g oral fructose, were compared in 12 control subjects and 13 patients with liver disease. No serious adverse effects occurred following fructose ingestion, and in neither group did the plasma lactate concentration exceed 5.2 mmol/l. There were no significant differ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198843
更新日期:1982-01-01 00:00:00
abstract::Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197946
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND/AIMS:Grading gastric mucosal atrophy in antrum biopsy specimens remains a controversial subject because of limitations in interobserver agreement. We previously described a reliable, quantitative method for grading atrophy of the corpus mucosa with excellent reproducibility and good correlation with the Sydn...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076544
更新日期:2004-01-01 00:00:00