Effects of proton pump inhibitors on pediatric inflammatory esophagogastric polyps.

Abstract:

BACKGROUND:The aim of this study was to investigate the effects of proton pump inhibitors on symptomatic inflammatory esophagogastric polyps (IEPs) in a pediatric cohort and to determine the optimal duration of treatment. METHODS:The 11 patients with IEPs were managed with lansoprazole. Follow-up endoscopies were performed at 2 and 6 months after the start of medication. Medication was discontinued when the clinical symptoms completely resolved and the polyp size was reduced by more than 50% compared to the initial size. RESULTS:The initial polyp size was 13.7 ± 3.3 mm. After 2 months of medication, the polyp size was reduced to 8.0 ± 5.8 mm. At 6 months, the polyp size was 4.7 ± 2.2 mm. The mean duration of medication was 4.8 ± 2.1 months. The duration of medication and the change in the polyp size appeared to have a linear correlation (p < 0.001). According to the formula used to calculate polyp size, the optimal duration of treatment was more than 7 months for complete resolution of the polyps. CONCLUSIONS:Proton pump inhibitor was effective for the treatment of IEPs. About 5 months of lansoprazole was adequate to treat IEPs in children. The optimal duration for complete resolution of the polyp might be more than 7 months.

journal_name

Digestion

journal_title

Digestion

authors

Choi KE,Kim MJ,Lee JH,Lee JS,Lee JH,Choe YH

doi

10.1159/000327909

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

179-84

issue

3

eissn

0012-2823

issn

1421-9867

pii

000327909

journal_volume

85

pub_type

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