Abstract:
:The adaptive increase in bile flow was studied up to 24 h after selective biliary obstruction (SBO) in the rat. Between 6 and 12 h after SBO bile flow increased significantly, such that 12 and 24 h after SBO bile flow did not differ significantly from control. The prior administration of cycloheximide (300 micrograms/100 g) resulted in a significant impairment of the increase in bile flow normally occurring between 6 and 12 h after SBO. These data indicate that the adaptive response in bile flow is dependent on de novo protein synthesis and suggest that the protein composition of the plasma membrane may determine the adaptive increase in bile flow that occurs after SBO in the rat.
journal_name
Digestionjournal_title
Digestionauthors
Mackinnon M,Kohler Mdoi
10.1159/000198431subject
Has Abstractpub_date
1980-01-01 00:00:00pages
141-4issue
2eissn
0012-2823issn
1421-9867journal_volume
20pub_type
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