Pancreatitis-associated protein (HIP/PAP) gene expression is upregulated in NOD mice pancreas and localized in exocrine tissue during diabetes.

abstract：INTRODUCTION:Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. OBJECTIVES:The aim of this study was to establish a novel quantitative meth...

journal_title：Digestion

authors： Kishi K,Kaji N,Tsuru Y,Hori M

更新日期：2020-12-01 00:00:00

abstract：:At 1 year after a first resection, up to 80% of patients show an endoscopic recurrence, 10-20% have clinical relapse, and 5% have surgical recurrence. Smoking is one of the most important risk factors for postoperative recurrence. Preoperative disease activity and the severity of endoscopic lesions in the neoterminal ...

journal_title：Digestion

authors： Froehlich F,Juillerat P,Felley C,Mottet C,Vader JP,Burnand B,Michetti P,Gonvers JJ

更新日期：2005-01-01 00:00:00

abstract：:Chenodeoxycholic acid (CDCA) is an effective treatment for dissolving gallstones but experimental studies have suggested that it might be hepatotoxic. The present study is concerned with a group of patients undergoing medical therapy for gallstones for periods of 30 days up to 14 months with CDCA (15 mg/kg/day). Routi...

journal_title：Digestion

authors： Koch MM,Giampieri MP,Lorenzini I,Jezequel AM,Orlandi F

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND/AIMS:In patients with active ulcerative colitis (UC), pharmacologics, although initially effective in most patients, are associated with refractoriness, loss of response or unfavourable side effects as additional morbidity factors. Depletion of myeloid lineage leucocytes like the CD14(+)CD16(+) monocyte phen...

journal_title：Digestion

authors： Iida T,Ikeya K,Kato M,Abe J,Yamamoto M,Watanabe F,Sugimoto K,Hanai H

更新日期：2017-01-01 00:00:00

abstract：:8 children, known to have been hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive for more than 6 months and with chronic active hepatitis on biopsy, received 2.5 mg levamisole/kg/day, 2 days a week for 6-18 months. In 6 of the 8 children transaminases normalized within 4-18 months of thera...

journal_title：Digestion

authors： Fattovich G,Cadrobbi P,Crivellaro C,Pornaro E,Alberti A,Realdi G

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...

journal_title：Digestion

authors： Hollenbach M,Feisthammel J,Mössner J,Hoffmeister A

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to examine the relative importance of the enzymes ornithine decarboxylase (ODC) and diamine oxidase (DAO) in intestinal polyamine metabolism in normal rats. To study this we measured jejunal and ileal DAO and ODC activities and polyamine levels 2 h after injecting, in non-fasting male Wistar ...

journal_title：Digestion

authors： Rokkas T,Vaja S,Taylor P,Murphy GM,Dowling RH

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...

journal_title：Digestion

authors： Li M,Oshima T,Ito C,Yamada M,Tomita T,Fukui H,Miwa H

更新日期：2019-09-18 00:00:00

abstract：BACKGROUND/AIMS:Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS:An expert international group using the modified Delphi technique examined the q...

journal_title：Digestion

authors： Modlin IM,Hunt RH,Malfertheiner P,Moayyedi P,Quigley EM,Tytgat GN,Tack J,Heading RC,Holtman G,Moss SF,Vevey NERD Consensus Group.

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. The pathophysiological understanding of this disease is limited and no curative therapy is available so far. Therefore, most patients require long-lasting or even life-long immunosuppressive therapies for the suppressio...

journal_title：Digestion

authors： Vetter M,Neurath MF

更新日期：2018-01-01 00:00:00

abstract：:Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by ...

journal_title：Digestion

authors： Allan A,Jewell DP

更新日期：1985-01-01 00:00:00

abstract：:The rates of intracellular transport of newly synthesized amylase, lipase, trypsinogen and chymotrypsinogen were compared in the anaesthesized rat pancreas by measuring their rates of secretion while keeping their relative rates of synthesis in a steady state. It is concluded that pancreatic proteins are not transport...

journal_title：Digestion

authors： Iovanna J,Giorgi D,Dagorn JC

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The authors reported that the repair of submucosal tissue is important in ulcer healing. The kinetics of fibroblasts have not been well known in gastric ulcer healing. The effect of subcutaneous administration of indomethacin (1 mg/kg) to submucosal tissue was also examined. METHOD:Immunohistological stainin...

journal_title：Digestion

authors： Hirose Y,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J,Tsukamoto Y

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:Only the depth of submucosal invasion can be estimated prior to determining the indications for endoscopic submucosal dissection (ESD) as a curative treatment for colorectal carcinoma (CRC). Here we evaluated the outcomes of ESD for clinical T1 CRCs. METHODS:Of 660 patients who underwent ESD for CRC at...

journal_title：Digestion

authors： Asayama N,Oka S,Tanaka S,Hayashi N,Arihiro K,Chayama K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Double-filtration plasmapheresis (DFPP) together with interferon (IFN) administration produces a substantial reduction in the viral load during the early stages of treatment. METHODS:Based on their responses to previous pegylated IFN and ribavirin (PEG-IFN/RBV) therapy, 20 patients were divided int...

journal_title：Digestion

authors： Kim SR,Saito J,Imoto S,Komaki T,Nagata Y,Kim KI,Sasase N,Kimura N,Sasatani K,Konishi E,Hasegawa Y,Fujinami A,Ohta M,El-Shamy A,Tanaka Y,Sugano M,Sakashita M,Nakamura A,Tsuchida S,Makino T,Kawada T,Nakajima T,M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:We investigated the effects of indomethacin and rebamipide on the gut microbiota profiles using terminal restriction fragment polymorphism (T-RFLP) analysis. MATERIALS AND METHODS:Female C57BL/6J mice were given indomethacin (10 mg/kg, s.c.) once a day and 2.5 mg rebamipide orally 3 times a day. After ...

journal_title：Digestion

authors： Imaeda H,Fujimoto T,Takahashi K,Kasumi E,Fujiyama Y,Andoh A

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to evaluate the serum behavior of human pancreas-specific protein/procarboxypeptidase B (hPASP/PCPB) in the early phases of acute pancreatitis, and to calculate its sensitivity and specificity in comparison with those of serum amylase and lipase in the diagnosis of this illness. Twenty-six ac...

journal_title：Digestion

authors： Pezzilli R,Billi P,Platè L,Bongiovanni F,Morselli Labate AM,Miglioli M

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the effects of proton pump inhibitors on symptomatic inflammatory esophagogastric polyps (IEPs) in a pediatric cohort and to determine the optimal duration of treatment. METHODS:The 11 patients with IEPs were managed with lansoprazole. Follow-up endoscopies were perf...

journal_title：Digestion

authors： Choi KE,Kim MJ,Lee JH,Lee JS,Lee JH,Choe YH

更新日期：2012-01-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD) is a chronic illness causing recurrent typical and atypical symptoms. Possible complications include oesophagitis, ulcer, stricture and Barrett's oesophagus. Evidence suggests that the intraoesophageal pH correlates directly with the degree of mucosal injury. Proton pump inhibi...

journal_title：Digestion

authors： Savarino V,Dulbecco P

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIMS:Colonic endoscopic mucosal resection (EMR) is safe for patients without antithrombotic therapy; however, EMR is associated with several risks. This study was performed to evaluate the risk of delayed hemorrhage in patients undergoing EMR without antithrombotic therapy. METHODS:In the present retrospect...

journal_title：Digestion

authors： Tsuruta S,Tominaga N,Ogata S,Tsuruoka N,Sakata Y,Shimoda R,Eguchi Y,Anzai K,Hara M,Fujimoto K

更新日期：2019-01-01 00:00:00

abstract：:Natural motilin was investigated for its effect on gastrointestinal motor activity in anesthetized dogs. In doses starting from 10 ng/kg as single injection and 100 ng/kg-h as intravenous infusion, motilin induced phasic pressure changes in the lower esophageal sphincter (LES) and in the lumen of the fundus, antrum, a...

journal_title：Digestion

authors： Jennewein HM,Hummelt H,Siewert R,Waldeck F

更新日期：1975-01-01 00:00:00

abstract：AIMS:The primary objective of this study was to clarify the influence of histotype on the outcome of D1/D2 gastrectomized patients with pathologically proven R0 resection. The secondary objective was to demonstrate overall survival (OS), disease-free survival (DFS), and locoregional recurrence rates following standard ...

journal_title：Digestion

authors： Uslu A,Bati H,Postaci H,Nart A,Eliyatkin N,Yetis H,Corumlu B,Aykas A,Zengel B

更新日期：2012-01-01 00:00:00

abstract：:Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...

journal_title：Digestion

authors： Seidel ER,Ginty DD

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:A patency capsule (PC) can help predict capsule endoscope (CE) retention; however, PC tolerability is unknown in children. We retrospectively evaluated PC tolerability in school-aged children. METHODS:Sixty-one patients (median age, 12.9 years; range 7.4-17.3 years) who underwent PC examination were analyze...

journal_title：Digestion

authors： Tokuhara D,Watanabe K,Cho Y,Shintaku H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIMS:There are limited data concerning the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) after double-balloon endoscopy (DBE). The aim of the present study was to evaluate the long-term outcome of patients with OGIB after DBE. PATIENTS AND METHODS:Eighty-seven consecutive pa...

journal_title：Digestion

authors： Fujita M,Manabe N,Honda K,Tarumi K,Murao T,Katada S,Kimura Y,Matsumoto H,Kamada T,Shiotani A,Hata J,Haruma K

更新日期：2010-01-01 00:00:00

abstract：:A young Indian man presented in England with a 6-month history of diarrhoea which started just before leaving India. He was found to have tropical enteropathy and H. nana infestation, but while the infestation and symptoms disappeared with antihelminthic treatment, the tropical enteropathy persisted. Hymenolepiasis is...

journal_title：Digestion

authors： Cooper BT,Hodgson HJ,Chadwick VS

更新日期：1981-01-01 00:00:00

abstract：:Leukocytapheresis has recently been used to induce remission in patients with ulcerative colitis (UC) who fail to respond to corticosteroids. We could not find a report in the literature on leukocytapheresis for UC with gestational exacerbation. We have recently encountered this unique condition and report the details...

journal_title：Digestion

authors： Okada H,Makidono C,Takenaka R,Hiraoka S,Fujiwara A,Kato J,Kawahara Y,Kawamoto H,Mizuno M,Shiratori Y

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Westernization, above all associated changes in diet, has been postulated to be one of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn's disease and ulcerative colitis. SUMMARY:Diet represents a crucially important and intui...

journal_title：Digestion

authors： Schreiner P,Martinho-Grueber M,Studerus D,Vavricka SR,Tilg H,Biedermann L,on behalf of Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD). METHODS:Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administere...

journal_title：Digestion

authors： Taniguchi T,Tsukada H,Nakamura H,Kodama M,Fukuda K,Tominaga M,Seino Y

更新日期：1997-01-01 00:00:00

abstract：:The isoenzymatic pattern of aldolase was determined by immunoprecipitation with specific anti-aldolase A, B and C sera in 21 pathological liver tissues and in the sera of normals (n equals 20), liver cirrhotics (n equals 52) and hepatoma patients (n equals 22). The increase of aldolase A in primary liver cell carcinom...

journal_title：Digestion

authors： Lehmann FG,Kornacher J

更新日期：1975-01-01 00:00:00