Abstract:
BACKGROUND/AIMS:Combined pH-metry/multichannel intraluminal impedance (pH/MII) measurement enables to measure gastroesophageal reflux despite ongoing proton pump inhibitor therapy. The aim of our study was to evaluate the influence of an escalating medical anti-reflux therapy with 40 mg esomeprazole, 80 mg esomeprazole and 80 mg esomeprazole plus baclofen for the treatment of refractory pathological reflux as determined by pH/MII. METHODS:Symptomatic patients under 40 mg esomeprazole were screened by pH/MII. Patients with normal values in pH/MII were excluded; all others received 2 x 40 mg esomeprazole for another 4 weeks. Thereafter, the treatment effect was controlled by pH/MII. In the case of persistent pathological reflux, therapy was further escalated by adding baclofen and controlled after 3 months by pH/MII. RESULTS:45/138 (32.6%) patients showed pathological pH/MII despite ongoing therapy with 40 mg esomeprazole. In these, a significant reduction in liquid/mixed reflux events was observed after administering 2 x 40 mg (mean: 118.3 vs. mean: 66.6; p < 0.001), and pH/MII turned to normal in 32/45 (71.1%). Baclofen was additionally administered to 7/13 patients, which did not lead to a remarkable reduction in reflux events. CONCLUSION:In patients with abnormal pH/MII and persistent symptoms under 40 mg esomeprazole, we observed a significant reduction in liquid/mixed reflux events after increasing proton pump inhibitor dose up to 80 mg esomeprazole. Further escalation of therapy with baclofen has shown inconclusive results.
journal_name
Digestionjournal_title
Digestionauthors
Bajbouj M,Becker V,Phillip V,Wilhelm D,Schmid RM,Meining Adoi
10.1159/000221146subject
Has Abstractpub_date
2009-01-01 00:00:00pages
112-8issue
2eissn
0012-2823issn
1421-9867pii
000221146journal_volume
80pub_type
临床试验,杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND AND AIM:A recent basic study identified that Dicer is contained in exosomes derived from cancer cells and plays crucial roles in microRNA maturation and cancer development. Based on this novel basic concept, we analyzed the usefulness of serum exosomal Dicer as a diagnostic biomarker for gastrointestinal can...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510993
更新日期:2020-10-13 00:00:00
abstract:BACKGROUND/AIMS:Endoscopic definitions and management of Barrett's esophagus vary widely among countries. To examine the current situation regarding diagnosis, epidemiology, management and treatment of Barrett's esophagus in East Asian countries using a questionnaire-based survey. METHODS:Representative members of the...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000339778
更新日期:2012-01-01 00:00:00
abstract::Recently our studies have demonstrated that the central nervous system regulates in part mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase (ODC) activity is a key enzyme for polyamine synthesis which plays an important role for the intestinal mucosal growth. We have demonstrated tha...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051921
更新日期:2001-01-01 00:00:00
abstract::Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient and the provider. The American Society of Anesthesiologists h...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000285504
更新日期:2010-01-01 00:00:00
abstract::The aim of this study was to examine the relative importance of the enzymes ornithine decarboxylase (ODC) and diamine oxidase (DAO) in intestinal polyamine metabolism in normal rats. To study this we measured jejunal and ileal DAO and ODC activities and polyamine levels 2 h after injecting, in non-fasting male Wistar ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200411
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Determining the depth of invasion is important when considering therapeutic strategies for early gastric cancer (EGC). We determined the effects of learning the non-extension sign, that is, an index of T1b2 in EGC, on identifying its depth of invasion. METHODS:Endoscopic images of 40 EGC cases (20 showing p...
journal_title:Digestion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000498845
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the effects of proton pump inhibitors on symptomatic inflammatory esophagogastric polyps (IEPs) in a pediatric cohort and to determine the optimal duration of treatment. METHODS:The 11 patients with IEPs were managed with lansoprazole. Follow-up endoscopies were perf...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000327909
更新日期:2012-01-01 00:00:00
abstract::Plasma lactate and urate concentrations, following 50 g oral fructose, were compared in 12 control subjects and 13 patients with liver disease. No serious adverse effects occurred following fructose ingestion, and in neither group did the plasma lactate concentration exceed 5.2 mmol/l. There were no significant differ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198843
更新日期:1982-01-01 00:00:00
abstract::A young Indian man presented in England with a 6-month history of diarrhoea which started just before leaving India. He was found to have tropical enteropathy and H. nana infestation, but while the infestation and symptoms disappeared with antihelminthic treatment, the tropical enteropathy persisted. Hymenolepiasis is...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198551
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to evaluate the frequency of anatomic variations of the hepatic duct bifurcation using magnetic resonance cholangiopancreatography (MRCP). METHODS:A total of 1,160 consecutive patients, referred to our department for MRCP due to suspected pancreatobiliary disease or before liver tra...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000358558
更新日期:2014-01-01 00:00:00
abstract::Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051452
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies (IMT). However, the underlying UC remained active in some UC patients, despite the fact that CMV-DNA in colonic mucosa became negative after antiviral therapy. Therefore, new therapeutic strategies f...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000321911
更新日期:2011-01-01 00:00:00
abstract::108 adult patients and 34 children with chronic active hepatitis (CAH) are divided in four groups on the basis of presence and absence of hepatitis B surface antigen (HBsAg) and autoantibodies (AutoAb). There are significant differences in the numeric distribution among the four groups and the sex distribution between...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198011
更新日期:1977-01-01 00:00:00
abstract::Pharmacological management of acute variceal hemorrhage appears to be effective in patients with liver cirrhosis. Somatostatin and presumably its longer-acting analog, octreotide, are more efficient and safer than other vasoconstrictors like vasopressin, terlipressin or their combination with nitroglycerin. Drug treat...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201115
更新日期:1994-01-01 00:00:00
abstract::The effects of two recently developed gastrin receptor antagonists, PD 136450 and L-365,260, on pentagastrin-stimulated acid secretion were investigated in rats. PD 136450 at a dose of 6 mg/kg s.c. (9.6 mumol) completely abolished acid secretion induced by pentagastrin. The inhibition of 18 mg/kg PD 136450 s.c. lasted...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200993
更新日期:1992-01-01 00:00:00
abstract::Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restric...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199576
更新日期:1987-01-01 00:00:00
abstract::Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198444
更新日期:1980-01-01 00:00:00
abstract::In the dog pancreas in vivo, the biological activity of secretin and vasoactive intestinal peptide was compared to that of secretin analogues modified in their N-terminal hexapeptide and to X-secretion (alpha, beta-Asp3-secretin) and Y-secretin (a conversion product of X-secretin consisting of about 15% secretin and 8...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198600
更新日期:1981-01-01 00:00:00
abstract::We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201406
更新日期:1996-01-01 00:00:00
abstract::The form in which copper is bound in bile was studied in bile from patients with Wilson's disease, control subjects and rats. Bile was labelled with 64Cu. Sephadex column chromatography using gels G-200--G-10 showed a major 64Cu and protein peak of about 5,000 daltons and a minor peak of about 8,000 daltons. A high-mo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198027
更新日期:1977-01-01 00:00:00
abstract::In order to study some of the molecular events during the hepatic passage of gastrin, we perfused sulfated natural porcine gastrin (G17 II) through isolated pig livers. The disappearance half time of G17 II was about 20-30 min when the starting gastrin concentrations were greater than 100 pM; lower concentrations were...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199029
更新日期:1984-01-01 00:00:00
abstract::Surgery is the only potentially curative treatment for patients with carcinoid tumors. Patients with localized disease even with lymph node metastases can be resected for potential cure. Patients with distant metastatic disease have been reported to be cured by resection of all tumor. However, long-term follow-up of t...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201209
更新日期:1994-01-01 00:00:00
abstract::The influences of secretagogues and of elevated serum calcium concentrations on the calcium secretion from the cat pancreas have been studied in vivo. During a high and constant fluid secretion rate evoked by a background infusion of secretin, additional infusions of both cholecystokinin-pancreozymin and urecholine le...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198873
更新日期:1983-01-01 00:00:00
abstract::Diamine oxidase (DAO) is an enzyme located almost exclusively in the villus tip enterocytes of mammals. Its plasma activity, normally very low, is enhanced by intravenous heparin that releases the enzyme from the enterocytes into the blood. Postheparin plasma DAO (PHD) values have been shown to be significantly reduce...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199731
更新日期:1988-01-01 00:00:00
abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200869
更新日期:1992-01-01 00:00:00
abstract::Familial colorectal cancer (CRC) is heterogeneous. Screening recommendations do exist for individuals with a mild to moderate family history of CRC, with or without early age at onset. However, most attention has properly focused on the identification of individuals in whom a defined susceptibility gene mutation can b...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000108395
更新日期:2007-01-01 00:00:00
abstract::Omeprazole was administered for up to 6 years in 859 patients for 'prevention of relapse in patients with poorly responsive peptic ulcer or reflux oesophagitis'. The pattern of adverse events reported during long-term treatment was similar to the adverse-event profile in short-term treatment with omeprazole (n = 2,818...
journal_title:Digestion
pub_type: 杂志文章,meta分析
doi:10.1159/000200922
更新日期:1992-01-01 00:00:00
abstract::The effects of secretin and caerulein on the absorption of water, sodium, potassium and glucose from the jejunum of dogs were investigated. Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period. Adding an intravenous ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199369
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:The present study aimed to evaluate the micronucleus (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in the mitogen-stimulated lymphocytes of patients with ulcerative colitis (UC). In addition, we assessed MN frequency in exfoliated colonic epithelial cells obtained from both the diseased and heal...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000336358
更新日期:2012-01-01 00:00:00
abstract::Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200908
更新日期:1992-01-01 00:00:00