Abstract:
BACKGROUND AND AIM:The medical treatment of rheumatoid arthritis (RA) includes nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose corticosteroids, and disease-modifying antirheumatic drugs (DMARDs). We evaluated the incidence of small bowel injury in RA patients who were taking anti-RA drugs with or without concomitant NSAIDs by capsule endoscopy. METHODS:A total of 28 RA patients who took low-dose corticosteroids and/or DMARDs for more than 1 year were enrolled. RESULTS:The incidence of red spots did not differ between the 2 groups: 14 of 16 patients (87.5%) in the NSAID group and 11 of 12 patients (91.7%) in the non-NSAID group. In contrast, the incidence of mucosal breaks was significantly higher in the NSAID group than in the non-NSAID group: mucosal breaks were detected in 13 of 16 patients (81.3%) and 4 of 12 patients (33.3%) in the NSAID and non-NSAID groups, respectively. In the NSAID group, mucosal breaks developed in users of preferential cyclooxygenase-2 inhibitors at a frequency similar to that in users of traditional NSAIDs. CONCLUSION:Patients taking anti-RA drugs may have an increased frequency of small bowel injury regardless of NSAID use, and NSAID use may be associated with an increased incidence of severe small bowel injury.
journal_name
Digestionjournal_title
Digestionauthors
Sugimori S,Watanabe T,Tabuchi M,Kameda N,Machida H,Okazaki H,Tanigawa T,Yamagami H,Shiba M,Watanabe K,Tominaga K,Fujiwara Y,Oshitani N,Koike T,Higuchi K,Arakawa Tdoi
10.1159/000190403subject
Has Abstractpub_date
2008-01-01 00:00:00pages
208-13issue
4eissn
0012-2823issn
1421-9867pii
000190403journal_volume
78pub_type
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